ID   A0A0H4CBV8_9ACTN        Unreviewed;       391 AA.
AC   A0A0H4CBV8;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   SubName: Full=Alcohol dehydrogenase {ECO:0000313|EMBL:AKN72126.1};
GN   ORFNames=QR97_22205 {ECO:0000313|EMBL:AKN72126.1};
OS   Streptomyces sp. PBH53.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1577075 {ECO:0000313|EMBL:AKN72126.1, ECO:0000313|Proteomes:UP000036399};
RN   [1] {ECO:0000313|EMBL:AKN72126.1, ECO:0000313|Proteomes:UP000036399}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PBH53 {ECO:0000313|EMBL:AKN72126.1,
RC   ECO:0000313|Proteomes:UP000036399};
RX   PubMed=26227608;
RA   Gosse J.T., Hill P., Dowd S.E., Boddy C.N.;
RT   "Draft Genome Sequence of Streptomyces sp. Strain PBH53, Isolated from an
RT   Urban Environment.";
RL   Genome Announc. 3:e00859-e00815(2015).
RN   [2] {ECO:0000313|Proteomes:UP000036399}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PBH53 {ECO:0000313|Proteomes:UP000036399};
RA   Gosse J.T., Boddy C.N., Hill P.B.;
RT   "Draft Genome Sequence of Streptomyces sp. strain PBH53, isolated from
RT   urban environment.";
RL   Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
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DR   EMBL; CP011799; AKN72126.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0H4CBV8; -.
DR   STRING; 1577075.QR97_22205; -.
DR   PATRIC; fig|1577075.3.peg.4592; -.
DR   Proteomes; UP000036399; Chromosome.
DR   CDD; cd08283; FDH_like_1; 1.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR013154; ADH-like_N.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR42813:SF2; DEHYDROGENASE, ZINC-CONTAINING, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02810)-RELATED; 1.
DR   PANTHER; PTHR42813; ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000036399};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          26..146
FT                   /note="Alcohol dehydrogenase-like N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08240"
FT   DOMAIN          196..267
FT                   /note="Alcohol dehydrogenase-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00107"
SQ   SEQUENCE   391 AA;  41720 MW;  31D0F10717EF08F6 CRC64;
     MKALCWEGVD KLAVEQVPDP VLRNDQDVIV RLIAGTTCGS DLHLIGGYIP FMRAGDVIGH
     EFLGEVVEVG SAVRRHKAGD RVVVCSFVGC GRCWYCAHDL WSLCDNTNTN PGIGQALFGA
     DTGGIFGYSH AMGGLRGSHA EYVRVPFADY GAFPVPDGVD DTSALFVSDS VPTGWMGADL
     AGVKPGDVVA VWGCGAVGQM AARAAILLGA ERVISIDRIP ERLEMTERHI GSEVIDYTST
     DIGAELRERT GGRGPDVCIE AVGMEAHSDS PVHLYDQVKQ QLRLQTDRPT AVRQAIHACC
     KGGTVFVLGV FAGAVDKFPL GAVINKGLTV RGAQQHGQRY IPMLLDRLAA GELSTAHLAT
     HTVPLDQAPR AYEMFKEKTD GCVRAVIRPG G
//