ID   A0A0H4VQ28_9BACT        Unreviewed;       352 AA.
AC   A0A0H4VQ28;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   SubName: Full=Hydroxyacid dehydrogenase {ECO:0000313|EMBL:AKQ46037.1};
GN   ORFNames=TH63_10930 {ECO:0000313|EMBL:AKQ46037.1};
OS   Rufibacter radiotolerans.
OC   Bacteria; Bacteroidota; Cytophagia; Cytophagales; Hymenobacteraceae;
OC   Rufibacter.
OX   NCBI_TaxID=1379910 {ECO:0000313|EMBL:AKQ46037.1, ECO:0000313|Proteomes:UP000036458};
RN   [1] {ECO:0000313|EMBL:AKQ46037.1, ECO:0000313|Proteomes:UP000036458}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DG31D {ECO:0000313|EMBL:AKQ46037.1,
RC   ECO:0000313|Proteomes:UP000036458};
RA   Kim M.K., Srinivasan S., Lee J.-J.;
RT   "Rufibacter sp./DG31D/ whole genome sequencing.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947,
CC         ECO:0000256|RuleBase:RU361277};
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. {ECO:0000256|ARBA:ARBA00008072, ECO:0000256|RuleBase:RU361277}.
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DR   EMBL; CP010777; AKQ46037.1; -; Genomic_DNA.
DR   RefSeq; WP_048920972.1; NZ_CP010777.1.
DR   AlphaFoldDB; A0A0H4VQ28; -.
DR   STRING; 1379910.TH63_10930; -.
DR   KEGG; ruf:TH63_10930; -.
DR   PATRIC; fig|1379910.4.peg.2377; -.
DR   OrthoDB; 9806940at2; -.
DR   Proteomes; UP000036458; Chromosome.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd05283; CAD1; 1.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR013154; ADH-like_N.
DR   InterPro; IPR002328; ADH_Zn_CS.
DR   InterPro; IPR047109; CAD-like.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020843; PKS_ER.
DR   PANTHER; PTHR42683; ALDEHYDE REDUCTASE; 1.
DR   PANTHER; PTHR42683:SF85; CINNAMYL ALCOHOL DEHYDROGENASE 6-RELATED; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00059; ADH_ZINC; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|RuleBase:RU361277};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000036458};
KW   Zinc {ECO:0000256|RuleBase:RU361277}.
FT   DOMAIN          11..342
FT                   /note="Enoyl reductase (ER)"
FT                   /evidence="ECO:0000259|SMART:SM00829"
SQ   SEQUENCE   352 AA;  38197 MW;  3455101B10D950BE CRC64;
     MIATKGYAAF DPNSPLAPFN FERREVGPHD VMIEIQFCGV CHSDLHTAKG EWPGVMYPVV
     PGHEIVGRVV RVGDHVSRFK KDDLAGVGCM VNSCRTCPSC QEGLEQYCEN GNIGTYNSPE
     AGMDSPTFGG YSNQIVVNED FVLKIREDQD LARVAPLLCA GITTYSPLRQ WNIGQGHRVA
     VVGLGGLGHM AVKIAAAMGA DVTVLSTSAN KEADARALGA HNFVVTKDPE AFKAARNSFD
     FILNTVSAKM NLDEYVNLLK LDGTMILLGV PPEALALHPG SLIFKRRRIA GSLIGGIAET
     QEMLDFCAHH RILSDIEIIN IAQINTAYDR MLAGDVKYRF VIDMATLEDT SA
//