ID A0A0H4VRB4_9BACT Unreviewed; 632 AA.
AC A0A0H4VRB4;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=acetate--CoA ligase {ECO:0000256|ARBA:ARBA00013275};
DE EC=6.2.1.1 {ECO:0000256|ARBA:ARBA00013275};
GN ORFNames=TH63_12775 {ECO:0000313|EMBL:AKQ46299.1};
OS Rufibacter radiotolerans.
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Hymenobacteraceae;
OC Rufibacter.
OX NCBI_TaxID=1379910 {ECO:0000313|EMBL:AKQ46299.1, ECO:0000313|Proteomes:UP000036458};
RN [1] {ECO:0000313|EMBL:AKQ46299.1, ECO:0000313|Proteomes:UP000036458}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DG31D {ECO:0000313|EMBL:AKQ46299.1,
RC ECO:0000313|Proteomes:UP000036458};
RA Kim M.K., Srinivasan S., Lee J.-J.;
RT "Rufibacter sp./DG31D/ whole genome sequencing.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP010777; AKQ46299.1; -; Genomic_DNA.
DR RefSeq; WP_048921273.1; NZ_CP010777.1.
DR AlphaFoldDB; A0A0H4VRB4; -.
DR STRING; 1379910.TH63_12775; -.
DR KEGG; ruf:TH63_12775; -.
DR PATRIC; fig|1379910.4.peg.2771; -.
DR OrthoDB; 9778383at2; -.
DR Proteomes; UP000036458; Chromosome.
DR GO; GO:0003987; F:acetate-CoA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0016208; F:AMP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0019427; P:acetyl-CoA biosynthetic process from acetate; IEA:InterPro.
DR CDD; cd05966; ACS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR011904; Ac_CoA_lig.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR NCBIfam; TIGR02188; Ac_CoA_lig_AcsA; 1.
DR PANTHER; PTHR24095; ACETYL-COENZYME A SYNTHETASE; 1.
DR PANTHER; PTHR24095:SF14; ACETYL-COENZYME A SYNTHETASE 1; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:AKQ46299.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000036458}.
FT DOMAIN 11..66
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 68..454
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 516..595
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 632 AA; 71650 MW; 0630D01602DEA76A CRC64;
MDYRINSFEE YQETYQRSVE QPEEFWADIA DTFVWRKKWD KVLDWNFVEP KVKWFVNGKL
NITENCLDRH LEKRGNKLAL IWEPNDPKER FVRFTYRELH EKVCQMANVL KRNGVKKGDR
VVIYLPMIPE LAFSMLACAR IGAVHSVIFA GFSHTAMADR INDAQAKVVI TSDGLNRGSK
QIPVKRVVDE AVADCPSVEK MIVVERVSWA VQMKEGRDVW YHEELEQVDK NCPAEEMDAE
DLLFILYTSG STGKPKGVVH TCGGYMVYTD YTFRNVFQYQ ESDIYWCTAD LGWVTGHSYL
LYGPLLSGAT TLMFEGVPTF PDPGRFWQVI DKFGVNIFYT APTAIRSLMA SGLDHVLSYS
LDSLRVLGSV GEPINEEAWY WYYIHVGKER CPVVDTWWQT ETGGIMLSSL ANVTPTKPGH
AAYALPGVQP ILVDQAGEEI TENDQEGYLC VKFPWPGMIR TTYGDHERCR QSYFSSYKNL
YFTGDGAKRD KDGLWRIIGR VDDVINVSGH RFGTAEIENA INQNKHIVES AVVGYPHDVK
GQGIYAFVVC GDEIPQSPEN LRAEVIETVV DQIGKIARPD KIQIVSGLPK TRSGKIMRRI
LRKIAEGETS NLGDTSTLLD PPIVDEIIKG AL
//
