ID A0A0H4VWK9_9BORD Unreviewed; 1129 AA.
AC A0A0H4VWK9;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN Name=addA {ECO:0000313|EMBL:AKQ54892.1};
GN ORFNames=ACR54_01568 {ECO:0000313|EMBL:AKQ54892.1};
OS Bordetella hinzii.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Alcaligenaceae; Bordetella.
OX NCBI_TaxID=103855 {ECO:0000313|EMBL:AKQ54892.1, ECO:0000313|Proteomes:UP000036382};
RN [1] {ECO:0000313|EMBL:AKQ54892.1, ECO:0000313|Proteomes:UP000036382}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F582 {ECO:0000313|EMBL:AKQ54892.1,
RC ECO:0000313|Proteomes:UP000036382};
RX PubMed=26316634;
RA Weigand M.R., Changayil S., Kulasekarapandian Y., Tondella M.L.;
RT "Complete Genome Sequences of Two Bordetella hinzii Strains Isolated from
RT Humans.";
RL Genome Announc. 3:e00965-e00915(2015).
RN [2] {ECO:0000313|Proteomes:UP000036382}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F582 {ECO:0000313|Proteomes:UP000036382};
RA Weigand M.R., Changayil S., Kulasekarapandian Y., Batra D., Williams M.M.,
RA Tondella M.L.;
RT "Complete Genome Sequences of Two Bordetella hinzii Isolated from Humans.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR EMBL; CP012076; AKQ54892.1; -; Genomic_DNA.
DR RefSeq; WP_029577485.1; NZ_LT906461.1.
DR AlphaFoldDB; A0A0H4VWK9; -.
DR STRING; 103855.ACR54_01568; -.
DR KEGG; bhz:ACR54_01568; -.
DR PATRIC; fig|103855.15.peg.1547; -.
DR eggNOG; COG1074; Bacteria.
DR Proteomes; UP000036382; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000036382}.
FT DOMAIN 5..481
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 493..789
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 903..922
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 26..33
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1129 AA; 122082 MW; 1769081FE9F4C61A CRC64;
MSERQPRDHA ARLRALDPQA SFIVQAPAGS GKTELLTDRI LALLATVNKP EEIVAITFTR
KAASEMHARV LEKLARARGP EPEAEHERRS WRLARAALAR DAERGWHVLR HPARLAIRTI
DSFCAGLVRG MPWLSGLGGM PGIADDARAH YEAAARATLA LADEHESIVN LLAHLDVDVQ
AAEQAIADML GQRDQWLPLL AHGLDRDRLE EDLAETLGGE LRALGRAMPR GFDAALCGPA
SMAAAELSGS GDARLAPLLD WSQPLLPEAS DLPRWRALAH LLLTGAGSLR SPKGVTKALG
FPAKCAHKEA FVQWLSGHDG GEPWIARLAA LRDMPDARFT DAQWDMLSAQ LVTLALSVGQ
LQKVFAEAGE VDFIEIAQRA WHALGDADDP GELLLKLDAS IRHLLVDEFQ DTSQTQIDLL
TTLTAGWQPG DGRTLFLVGD PMQSIYRFRK AEVGLFLGAT EKGIGALRLE FLQLTDNFRS
QGGVVDWVNK SFADLLPAEN DAVAGAIRYS PSAAFHPALD GDAVRFHPAW AADGLASGDQ
AAEDIAVALA RQALAEHAGS AHPVAILVRA RAHLGSLSRR LAQEGIPSRA VELVPLRLRP
VVADLVQLLR ALTHPADRMA WLSVLRAPWC GLTLDSLQRL FGHDHRAPIP DLLRQALAEP
VAVPPQASLF DAPPVGGNGA ARLCLAPEEH ARLSRVAAIL LDRGNDSGAW PLAAWLQSVW
QALGGAGLYP GVGAAADAES LFQLVERLAP HGGLDIAALD TAVGRLFAAP DVQGEQGAVE
IMTMHKSKGL QFDSVILYGL HRVPRGDQAP LVRFEHHNGR VLMGPIKARA DTEADPVSRY
LGAREARRAA YETDRLLYVA ATRARKRLHL IGNVALDEEK GPRAPAASSL LGRLWPHIRA
GQAPQPVREA APGPAASPAW QGEPLKRLDD ASVAALAALP RRGAQPGGLA ADAEHPAWQW
EAGHEAAVGT LAHAWLARMG EEGGDHWDAE RLREHRPAMR RQLTRAGIPD SQADSAADAV
LQTLQATLAH ERGLWLLRQS RARREWPLID AAGRVSVIDL ALSTEDGWLI VDYKTGQAQP
GESPAHFAQR MRLRHADQLK RYCAQVTALD GRPARAALYF PRAQAWIEL
//
