UniProt: A0A0H4VY70

Database: UniProt
Entry: A0A0H4VY70_9BORD

LinkDB:  A0A0H4VY70_9BORD 
Original site:  A0A0H4VY70_9BORD

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Ontology (2)   
   GO (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (2)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (2)   
   EMBL (2)   
Protein domain (7)   
   InterPro (5)   
   Pfam (2)   
Literature (2)   
   PubMed (2)   
All databases (17)   

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ID   A0A0H4VY70_9BORD        Unreviewed;       493 AA.
AC   A0A0H4VY70;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   RecName: Full=Exopolyphosphatase {ECO:0000256|ARBA:ARBA00020416};
DE            EC=3.6.1.11 {ECO:0000256|ARBA:ARBA00012451};
GN   Name=ppx {ECO:0000313|EMBL:AKQ54920.1};
GN   ORFNames=ACR54_01596 {ECO:0000313|EMBL:AKQ54920.1}, CS347_00230
GN   {ECO:0000313|EMBL:AZW15334.1};
OS   Bordetella hinzii.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Alcaligenaceae; Bordetella.
OX   NCBI_TaxID=103855 {ECO:0000313|EMBL:AKQ54920.1, ECO:0000313|Proteomes:UP000036382};
RN   [1] {ECO:0000313|EMBL:AKQ54920.1, ECO:0000313|Proteomes:UP000036382}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=F582 {ECO:0000313|EMBL:AKQ54920.1,
RC   ECO:0000313|Proteomes:UP000036382};
RX   PubMed=26316634;
RA   Weigand M.R., Changayil S., Kulasekarapandian Y., Tondella M.L.;
RT   "Complete Genome Sequences of Two Bordetella hinzii Strains Isolated from
RT   Humans.";
RL   Genome Announc. 3:e00965-e00915(2015).
RN   [2] {ECO:0000313|Proteomes:UP000036382}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=F582 {ECO:0000313|Proteomes:UP000036382};
RA   Weigand M.R., Changayil S., Kulasekarapandian Y., Batra D., Williams M.M.,
RA   Tondella M.L.;
RT   "Complete Genome Sequences of Two Bordetella hinzii Isolated from Humans.";
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Proteomes:UP000282741}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H720 {ECO:0000313|Proteomes:UP000282741};
RA   Weigand M.R., Loparev V., Peng Y., Bowden K.E., Tondella M.L.,
RA   Williams M.M.;
RT   "Whole genome sequencing of various Bordetella species.";
RL   Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:AZW15334.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=H720 {ECO:0000313|EMBL:AZW15334.1};
RX   PubMed=31744907;
RA   Weigand M.R., Peng Y., Batra D., Burroughs M., Davis J.K., Knipe K.,
RA   Loparev V.N., Johnson T., Juieng P., Rowe L.A., Sheth M., Tang K.,
RA   Unoarumhi Y., Williams M.M., Tondella M.L.;
RT   "Conserved Patterns of Symmetric Inversion in the Genome Evolution of
RT   Bordetella Respiratory Pathogens.";
RL   mSystems 4:e00702-19(2019).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[phosphate](n) + H2O = [phosphate](n-1) + H(+) + phosphate;
CC         Xref=Rhea:RHEA:21528, Rhea:RHEA-COMP:9859, Rhea:RHEA-COMP:14279,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16838,
CC         ChEBI:CHEBI:43474; EC=3.6.1.11;
CC         Evidence={ECO:0000256|ARBA:ARBA00000209};
CC   -!- SIMILARITY: Belongs to the GppA/Ppx family.
CC       {ECO:0000256|ARBA:ARBA00007125}.
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DR   EMBL; CP012076; AKQ54920.1; -; Genomic_DNA.
DR   EMBL; CP024172; AZW15334.1; -; Genomic_DNA.
DR   RefSeq; WP_029577457.1; NZ_LT906461.1.
DR   STRING; 103855.ACR54_01596; -.
DR   GeneID; 56618561; -.
DR   KEGG; bhz:ACR54_01596; -.
DR   PATRIC; fig|103855.14.peg.1536; -.
DR   eggNOG; COG0248; Bacteria.
DR   OrthoDB; 9793035at2; -.
DR   Proteomes; UP000036382; Chromosome.
DR   Proteomes; UP000282741; Chromosome.
DR   GO; GO:0004309; F:exopolyphosphatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006793; P:phosphorus metabolic process; IEA:InterPro.
DR   Gene3D; 3.30.420.40; -; 1.
DR   Gene3D; 3.30.420.150; Exopolyphosphatase. Domain 2; 1.
DR   Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR022371; Exopolyphosphatase.
DR   InterPro; IPR048950; Ppx_GppA_C.
DR   InterPro; IPR003695; Ppx_GppA_N.
DR   InterPro; IPR030673; PyroPPase_GppA_Ppx.
DR   NCBIfam; TIGR03706; exo_poly_only; 1.
DR   PANTHER; PTHR30005; EXOPOLYPHOSPHATASE; 1.
DR   PANTHER; PTHR30005:SF0; RETROGRADE REGULATION PROTEIN 2; 1.
DR   Pfam; PF02541; Ppx-GppA; 1.
DR   Pfam; PF21447; Ppx-GppA_III; 1.
DR   PIRSF; PIRSF001267; Pyrophosphatase_GppA_Ppx; 1.
DR   SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR   SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000313|EMBL:AKQ54920.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000036382}.
FT   DOMAIN          23..302
FT                   /note="Ppx/GppA phosphatase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02541"
FT   DOMAIN          311..477
FT                   /note="Ppx/GppA phosphatase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF21447"
SQ   SEQUENCE   493 AA;  54747 MW;  2024E9C3AEFAA970 CRC64;
     MDHLLAAVDL GSNSFRLSIG RVVQQDGVAQ IYQIDRLKET VRLAAGLGQD KILGHEAIDR
     AVGVLERFGE RLRSFHPNRV RAVATNTFRV ARNTPDFLPR AEAALGFPIE VIAGREEARL
     IFTGVAHSLP PSPNKRLVID IGGGSTEVII GKGLDPNLMS SLYMGCVSYS RQFFPDGRVD
     GTAMKQAEIA ARREIEVIAK QYRKMGWKEA YGSSGTAKAL FAILTECGFA RAITAAGMAK
     LKDRIIRSGK VIPSELPGIK LERADVLPGG LAIMSALFDE LGIEVMHTGD GALRLGVLYD
     LIGRDDRHDK RDESVRQFMK RYHVDVNQAR RVRQTALALF DELMPEGAER AELRNAIGWT
     ADLHEVGLSI AHNAYHKHSA YVLENADMPG FSRADQQLMA MLALASQGKL TKAEALVRSR
     GQWIAILCLR MAVLLLRRRE DTPLPFKLKI EGTHIQVEIP REWLDSHPLT DFTLQGEVSE
     WRKVGFAFEL LER
//

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