UniProt: A0A0H5BC64

Database: UniProt
Entry: A0A0H5BC64_BLAVI

LinkDB:  A0A0H5BC64_BLAVI 
Original site:  A0A0H5BC64_BLAVI

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Ontology (6)   
   GO (6)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (1)   
   KEGG GENES (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (2)   
   EMBL (2)   
Protein domain (8)   
   InterPro (6)   
   Pfam (1)   
   PROSITE (1)   
Literature (1)   
   PubMed (1)   
All databases (20)   

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ID   A0A0H5BC64_BLAVI        Unreviewed;       295 AA.
AC   A0A0H5BC64;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   27-MAR-2024, entry version 45.
DE   RecName: Full=Branched-chain-amino-acid aminotransferase {ECO:0000256|RuleBase:RU364094};
DE            Short=BCAT {ECO:0000256|RuleBase:RU364094};
DE            EC=2.6.1.42 {ECO:0000256|RuleBase:RU364094};
GN   Name=ilvE {ECO:0000256|RuleBase:RU364094,
GN   ECO:0000313|EMBL:CUU42884.1};
GN   ORFNames=BV133_2254 {ECO:0000313|EMBL:BAR99847.1}, BVIRIDIS_18990
GN   {ECO:0000313|EMBL:CUU42884.1};
OS   Blastochloris viridis (Rhodopseudomonas viridis).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC   Blastochloridaceae; Blastochloris.
OX   NCBI_TaxID=1079 {ECO:0000313|EMBL:CUU42884.1, ECO:0000313|Proteomes:UP000065734};
RN   [1] {ECO:0000313|EMBL:BAR99847.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 133 {ECO:0000313|EMBL:BAR99847.1};
RA   Tsukatani Y., Hirose Y., Harada J., Misawa N., Mori K., Inoue K.,
RA   Tamiaki H.;
RT   "Complete Genome Sequence of the Bacteriochlorophyll b-Producing
RT   Photosynthetic Bacterium Blastochloris viridis.";
RL   Genome Announc. 3:e01006-15(2015).
RN   [2] {ECO:0000313|EMBL:CUU42884.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=1 {ECO:0000313|EMBL:CUU42884.1};
RA   Zhang Y., Guo Z.;
RL   Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Proteomes:UP000065734}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19567 / DSM 133 / F {ECO:0000313|Proteomes:UP000065734};
RX   PubMed=26798090; DOI=10.1128/genomeA.01520-15;
RA   Liu L.N., Faulkner M., Liu X., Huang F., Darby A.C., Hall N.;
RT   "Revised genome sequence of the purple photosynthetic bacterium
RT   Blastochloris viridis.";
RL   Genome Announc. 4:0-0(2016).
CC   -!- FUNCTION: Acts on leucine, isoleucine and valine.
CC       {ECO:0000256|ARBA:ARBA00003109, ECO:0000256|RuleBase:RU364094}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoate +
CC         L-glutamate; Xref=Rhea:RHEA:24801, ChEBI:CHEBI:16810,
CC         ChEBI:CHEBI:29985, ChEBI:CHEBI:35146, ChEBI:CHEBI:58045; EC=2.6.1.42;
CC         Evidence={ECO:0000256|ARBA:ARBA00000627,
CC         ECO:0000256|RuleBase:RU364094};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-
CC         glutamate; Xref=Rhea:RHEA:18321, ChEBI:CHEBI:16810,
CC         ChEBI:CHEBI:17865, ChEBI:CHEBI:29985, ChEBI:CHEBI:57427; EC=2.6.1.42;
CC         Evidence={ECO:0000256|ARBA:ARBA00000995,
CC         ECO:0000256|RuleBase:RU364094};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoate + L-
CC         glutamate; Xref=Rhea:RHEA:24813, ChEBI:CHEBI:11851,
CC         ChEBI:CHEBI:16810, ChEBI:CHEBI:29985, ChEBI:CHEBI:57762; EC=2.6.1.42;
CC         Evidence={ECO:0000256|ARBA:ARBA00001745,
CC         ECO:0000256|RuleBase:RU364094};
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933,
CC         ECO:0000256|RuleBase:RU004516};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-isoleucine biosynthesis; L-
CC       isoleucine from 2-oxobutanoate: step 4/4.
CC       {ECO:0000256|ARBA:ARBA00004824, ECO:0000256|RuleBase:RU364094}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine
CC       from 3-methyl-2-oxobutanoate: step 4/4. {ECO:0000256|ARBA:ARBA00005072,
CC       ECO:0000256|RuleBase:RU364094}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-valine biosynthesis; L-valine from
CC       pyruvate: step 4/4. {ECO:0000256|ARBA:ARBA00004931,
CC       ECO:0000256|RuleBase:RU364094}.
CC   -!- SIMILARITY: Belongs to the class-IV pyridoxal-phosphate-dependent
CC       aminotransferase family. {ECO:0000256|ARBA:ARBA00009320,
CC       ECO:0000256|RuleBase:RU004106}.
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DR   EMBL; AP014854; BAR99847.1; -; Genomic_DNA.
DR   EMBL; LN907867; CUU42884.1; -; Genomic_DNA.
DR   RefSeq; WP_055037858.1; NZ_LN907867.1.
DR   AlphaFoldDB; A0A0H5BC64; -.
DR   STRING; 1079.BVIR_2453; -.
DR   KEGG; bvr:BVIR_2453; -.
DR   PATRIC; fig|1079.6.peg.2565; -.
DR   OrthoDB; 21319at2; -.
DR   UniPathway; UPA00047; UER00058.
DR   UniPathway; UPA00048; UER00073.
DR   UniPathway; UPA00049; UER00062.
DR   Proteomes; UP000065734; Chromosome I.
DR   GO; GO:0052656; F:L-isoleucine transaminase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052654; F:L-leucine transaminase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052655; F:L-valine transaminase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009097; P:isoleucine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0009099; P:valine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.30.470.10; -; 1.
DR   Gene3D; 3.20.10.10; D-amino Acid Aminotransferase, subunit A, domain 2; 1.
DR   InterPro; IPR001544; Aminotrans_IV.
DR   InterPro; IPR018300; Aminotrans_IV_CS.
DR   InterPro; IPR036038; Aminotransferase-like.
DR   InterPro; IPR005785; B_amino_transI.
DR   InterPro; IPR043132; BCAT-like_C.
DR   InterPro; IPR043131; BCAT-like_N.
DR   NCBIfam; TIGR01122; ilvE_I; 1.
DR   PANTHER; PTHR42743; AMINO-ACID AMINOTRANSFERASE; 1.
DR   PANTHER; PTHR42743:SF20; BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE-LIKE PROTEIN 2; 1.
DR   Pfam; PF01063; Aminotran_4; 1.
DR   SUPFAM; SSF56752; D-aminoacid aminotransferase-like PLP-dependent enzymes; 1.
DR   PROSITE; PS00770; AA_TRANSFER_CLASS_4; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU364094};
KW   Aminotransferase {ECO:0000256|RuleBase:RU364094,
KW   ECO:0000313|EMBL:CUU42884.1};
KW   Branched-chain amino acid biosynthesis {ECO:0000256|RuleBase:RU364094};
KW   Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW   ECO:0000256|RuleBase:RU004516};
KW   Reference proteome {ECO:0000313|Proteomes:UP000065734};
KW   Transferase {ECO:0000256|RuleBase:RU364094, ECO:0000313|EMBL:CUU42884.1}.
SQ   SEQUENCE   295 AA;  32628 MW;  D348CF51B21C8A0A CRC64;
     MALMPYDDRD GFIWFDGKLV PWRDAKIHVL THALHYGSGV FEGERAYNGV VFKSAEHSQR
     LKDSANILDF EVPWTVEQID AAKLAVMAAN GHTDCYVRPV AWRGSEEMGV GAHANTIHLA
     IASWVWPSYF DPELRKKGIR LDIADYRRPD PQTAPSTAKA AGLYMICTIS KHRAAAKGFT
     DAMMLDWQGR VAECTGANIF FVKDGVIHTP TADCFLNGIT RQTVIELAKR RGVEVAERRI
     LPEELTGFTE CFVTGTAAEV TPVGEIGPYR FTPAQLTAAL IEDYAAEVQP KKLAA
//

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