ID A0A0H5CTL3_9PSEU Unreviewed; 308 AA.
AC A0A0H5CTL3;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=2-hydroxy-3-oxopropionate reductase {ECO:0000313|EMBL:CRK55080.1};
DE EC=1.1.1.60 {ECO:0000313|EMBL:CRK55080.1};
OS Alloactinosynnema sp. L-07.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae.
OX NCBI_TaxID=1653480 {ECO:0000313|EMBL:CRK55080.1, ECO:0000313|Proteomes:UP000076116};
RN [1] {ECO:0000313|Proteomes:UP000076116}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=L-07 {ECO:0000313|Proteomes:UP000076116};
RA Ramaraj T.;
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the HIBADH-related family.
CC {ECO:0000256|ARBA:ARBA00009080}.
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DR EMBL; LN850107; CRK55080.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0H5CTL3; -.
DR STRING; 1653480.gene:80943933; -.
DR KEGG; alo:CRK55080; -.
DR OrthoDB; 3185659at2; -.
DR Proteomes; UP000076116; Chromosome i.
DR GO; GO:0008679; F:2-hydroxy-3-oxopropionate reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43580; OXIDOREDUCTASE GLYR1-RELATED; 1.
DR PANTHER; PTHR43580:SF2; OXIDOREDUCTASE GLYR1-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000313|EMBL:CRK55080.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000076116}.
FT DOMAIN 10..166
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 172..290
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 178
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 308 AA; 32220 MW; 781EF39BD4BAC658 CRC64;
MKGTEMTDKK VACLGLGGMG GGIAGRLTDL GWKPVLWNRS IEKAQTIAEG SGGVAITPAE
AVTGVDVAML SLADEPSVES VLFGENGVVS ALRKGAMVVD MSTVSPEYSR QVTGRLNELG
FRRVEANLVG NPMQARAGAA RVLAGGATED IDEVRELLTV IGRQLVELGA IGVAATLKLA
LNALLGSQVV ALAEVVNYGV EAGLDRDLLL RTIAESAFSS PVMSHRANLM REEKYVPAGF
RSVLMEKDLR LTVADAAIQG VQLPVIATAA RRYERMVAAG KGELDAAAIL DQQFADAGDE
TKSQVSAS
//
