ID   A0A0H5D1D6_9PSEU        Unreviewed;      1042 AA.
AC   A0A0H5D1D6;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   27-MAR-2024, entry version 37.
DE   RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE            EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
OS   Alloactinosynnema sp. L-07.
OC   Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC   Pseudonocardiaceae.
OX   NCBI_TaxID=1653480 {ECO:0000313|EMBL:CRK58335.1, ECO:0000313|Proteomes:UP000076116};
RN   [1] {ECO:0000313|Proteomes:UP000076116}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=L-07 {ECO:0000313|Proteomes:UP000076116};
RA   Ramaraj T.;
RL   Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR   EMBL; LN850107; CRK58335.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0H5D1D6; -.
DR   STRING; 1653480.gene:80947208; -.
DR   KEGG; alo:CRK58335; -.
DR   Proteomes; UP000076116; Chromosome i.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 6.10.340.10; -; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR013587; Nitrate/nitrite_sensing.
DR   PANTHER; PTHR44936; SENSOR PROTEIN CREC; 1.
DR   PANTHER; PTHR44936:SF12; SENSOR PROTEIN CREC; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF08376; NIT; 1.
DR   SMART; SM00387; HATPase_c; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
PE   4: Predicted;
KW   Kinase {ECO:0000313|EMBL:CRK58335.1}; Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000076116};
KW   Transferase {ECO:0000313|EMBL:CRK58335.1};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT   TRANSMEM        21..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        316..338
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          526..639
FT                   /note="Histidine kinase/HSP90-like ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00387"
FT   REGION          662..751
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          872..914
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          966..999
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1019..1042
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        663..708
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1042 AA;  110000 MW;  1C05B97A4BE65A04 CRC64;
     MSKSRWTALR QWRDWGIPVK LAAVTLVPVL FAIVLGVLQI GSQIDRADSY KQIDRLVTVN
     DTLHKTVTWL QRERTKAAVL LTSGSSDIGF ELVAERRSAD EAKAALLAAA DGLVFSNETT
     AARYTDVRTR FGELEVLRGK VGAREVDGPA ALAGYSTVVR ALIAFDRAAA EEVADPALSS
     TAGALHDLEA AKEEVHYQQG LLGIGIVRGA LAAAEVDGLR ASQARLDDRL ADFRAIANPA
     QQDEYARALP GAEAETRNVL VRRALDRGSR PGMPVAAADW NSASDLVSGK LSDISGTLGE
     QVKSGSAALQ DEASDAAGLA SVILIVALVA AAAIMLIIGR HLLRSLSALR RGALDVAEHR
     LPAAVAALRD GRDLAVPMVE PVAVVSADEV GEVARAFDAV HQQALRLATE QAGMRANYAG
     VFVNLSRRSQ GLVQRQLQLL ERLERDEEDA DQLATLFQLD HLATRMRRNN ENLMVLSGTA
     TGEVHHGRRS AQPVSLADLL RAAVSEVEQY QRVVIAPPPS VLVVGYAVGD LVRLTAELLD
     NAAAFSAPAT QVTISSHHVD GGTVRIEVSD RGIGMTADEL AEANTRLAED GVVDATTSRR
     MGLFVVGRLA ARHGIKVRLR PGAPTGLRAT VTVASDLVTS NVVGLPPVPA PVLDEPPAHT
     AGIKRTNGSN GSNGAKVKGT NGSAVNGTNG SAVNGSAVNG STVNGLPRRA PTNGVESFIP
     MTRGDGAEMP ESLPAPRDAG DLAAPLPRRD PKPVEPAVPA EFGMPAEPAG AVAWPSHPAP
     DLPAAEEISA DKLFAPQTPE AETTGWWDTT LVYGRPPGAD PVRDIQETTP IFDEMISAWF
     RTVTDDPNST VADAEQGPAW DFAADQGFQA AKSVSAAEPE DFTRSGLPRR TPRRNLVPGS
     IDSSPPTVPG RDADDLRTRL SSYQAGVHRA RGVHHTGPAH GNSDGLDLRG AQWRFAADAG
     WDAAATLGAS TPDTPADGGL PRRTPRERLL PGSLDPVPGT EIRVERDAEA LRGRLGSLQR
     GIGRGRESLA RQSTEQESGL DA
//