ID A0A0H5S693_BRUMA Unreviewed; 852 AA.
AC A0A0H5S693;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=BMA-EEF-2 {ECO:0000313|EMBL:CRZ23688.1};
DE SubName: Full=Translation elongation factor aEF-2, putative {ECO:0000313|WBParaSite:Bm13733.1};
GN Name=bma-eef-2 {ECO:0000313|WormBase:Bm13733};
GN Synonyms=Bma-eef-2 {ECO:0000313|EMBL:CRZ23688.1,
GN ECO:0000313|WBParaSite:Bm13733.1};
GN ORFNames=Bm13733 {ECO:0000313|WormBase:Bm13733}, BM_Bm13733
GN {ECO:0000313|EMBL:CRZ23688.1};
OS Brugia malayi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6279 {ECO:0000313|EMBL:CRZ23688.1};
RN [1] {ECO:0000313|EMBL:CRZ23688.1, ECO:0000313|Proteomes:UP000006672}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CRZ23688.1,
RC ECO:0000313|Proteomes:UP000006672};
RX PubMed=17885136; DOI=10.1126/science.1145406;
RA Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E.,
RA Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T.,
RA Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.,
RA Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M.,
RA Pop M., White O., Barton G.J., Carlow C.K., Crawford M.J., Daub J.,
RA Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F.,
RA Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.W.,
RA Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA Blaxter M.L., Scott A.L.;
RT "Draft genome of the filarial nematode parasite Brugia malayi.";
RL Science 317:1756-1760(2007).
RN [2] {ECO:0000313|EMBL:CRZ23688.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CRZ23688.1};
RA Gao Y.W., Fan S.T., Sun H.T., Wang Z., Gao X.L., Li Y.G., Wang T.C.,
RA Zhang K., Xu W.W., Yu Z.J., Xia X.Z.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|WBParaSite:Bm13733.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (DEC-2019) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; LN856906; CRZ23688.1; -; Genomic_DNA.
DR STRING; 6279.A0A0H5S693; -.
DR EnsemblMetazoa; Bm13733.1; Bm13733.1; WBGene00233994.
DR WBParaSite; Bm13733.1; Bm13733.1; WBGene00233994.
DR WormBase; Bm13733; BM30403; WBGene00233994; Bma-eef-2.
DR OMA; NRHNRFY; -.
DR OrthoDB; 166721at2759; -.
DR Proteomes; UP000006672; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0006412; P:translation; IEA:UniProtKB-KW.
DR CDD; cd01681; aeEF2_snRNP_like_IV; 1.
DR CDD; cd04096; eEF2_snRNP_like_C; 1.
DR CDD; cd01885; EF2; 1.
DR CDD; cd16261; EF2_snRNP_III; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.70.240; -; 1.
DR Gene3D; 3.30.70.870; Elongation Factor G (Translational Gtpase), domain 3; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR041095; EFG_II.
DR InterPro; IPR035647; EFG_III/V.
DR InterPro; IPR000640; EFG_V-like.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR005517; Transl_elong_EFG/EF2_IV.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR42908:SF10; ELONGATION FACTOR 2; 1.
DR PANTHER; PTHR42908; TRANSLATION ELONGATION FACTOR-RELATED; 1.
DR Pfam; PF00679; EFG_C; 1.
DR Pfam; PF14492; EFG_III; 1.
DR Pfam; PF03764; EFG_IV; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SMART; SM00838; EFG_C; 1.
DR SMART; SM00889; EFG_IV; 1.
DR SUPFAM; SSF54980; EF-G C-terminal domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000006672}.
FT DOMAIN 17..356
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 852 AA; 94917 MW; 4FA377B36595F8F5 CRC64;
MVNFTIEEIR GIMDHKKNIR NMSVIAHVDH GKSTLTDSLV SKAGIIAGAK AGETRFTDTR
KDEQERCITI KSTAISLFFE LEAKDLAFIK GESQVEVNTI NGEQKKLPGF LINLIDSPGH
VDFSSEVTAA LRVTDGALVV VDCVSGVCVQ TETVLRQAIA ERIKPVLFMN KMDRALLELQ
LGAEELYQTF QRIVENINVI IATYGDDDGP MGPIMVDPAV GNVGFGSGLH GWAFTLKQFA
EFYAEKFGVQ VEKLMRNLWG DRFFNMKTKK WTSTQDADSK RGFVQFVLDP IFKVFDAVMN
VKKEETAKLI EKLDIKLSND ERNLEGKPLM KVMMRKWLPA GDTMLQMICM HLPSPVTAQK
YRMEMLYEGP HDDEAAIAIR NCDPNGPLMM YVSKMVPTSD KGRFYAFGRV FSGKVATGMK
ARIQGPNFVP GKKEDLYEKT IQRTILMMGR YVEPIEDIPS GNIAGLVGVD QYLVKGGTIT
TYKDAHNLRV MKFSVSPVVR VAVEPKNAGD LPKLVEGLKR LAKSDPMVQC IFEESGEHII
AGAGELHLEI CLKDLEEDHA CIPIKKSDPV VSYRETVTEE SDQLCLSKSP NKHNRLFARA
LPMPDGLADD IDKGEINARD EMKSRAKILA EKYDYDVTEA RKIWCFGPDG TGANILVDVT
KGVQYLNEIK DSVVAGFQWA TKEGVLCDEN MRGVRINIHD VTLHADAIHR GGGQIIPTAR
RVFYASVLTA QPRLLEPVYL VEIQCPENAV GGIYGVLNRR RGHVFEESQV AGTPMFVVKA
YLPVNESFGF TADLRSNTGG QAFPQCVFDH WQVLQGNPLE PNTKPAQIVA EIRKRKGLKE
QIPGLDNFLD KM
//
