ID A0A0H5S6Q3_BRUMA Unreviewed; 249 AA.
AC A0A0H5S6Q3;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=BMA-EXOS-4.1 {ECO:0000313|EMBL:CRZ24270.1, ECO:0000313|WBParaSite:Bm1853.1};
GN Name=bma-exos-4.1 {ECO:0000313|WormBase:Bm1853};
GN Synonyms=Bma-exos-4.1 {ECO:0000313|EMBL:CRZ24270.1,
GN ECO:0000313|WBParaSite:Bm1853.1};
GN ORFNames=Bm1853 {ECO:0000313|WormBase:Bm1853}, BM_Bm1853
GN {ECO:0000313|EMBL:CRZ24270.1};
OS Brugia malayi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6279 {ECO:0000313|EMBL:CRZ24270.1};
RN [1] {ECO:0000313|EMBL:CRZ24270.1, ECO:0000313|Proteomes:UP000006672}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CRZ24270.1,
RC ECO:0000313|Proteomes:UP000006672};
RX PubMed=17885136; DOI=10.1126/science.1145406;
RA Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E.,
RA Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T.,
RA Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.,
RA Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M.,
RA Pop M., White O., Barton G.J., Carlow C.K., Crawford M.J., Daub J.,
RA Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F.,
RA Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.W.,
RA Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA Blaxter M.L., Scott A.L.;
RT "Draft genome of the filarial nematode parasite Brugia malayi.";
RL Science 317:1756-1760(2007).
RN [2] {ECO:0000313|EMBL:CRZ24270.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CRZ24270.1};
RA Gao Y.W., Fan S.T., Sun H.T., Wang Z., Gao X.L., Li Y.G., Wang T.C.,
RA Zhang K., Xu W.W., Yu Z.J., Xia X.Z.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|WBParaSite:Bm1853.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (DEC-2019) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RNase PH family.
CC {ECO:0000256|ARBA:ARBA00006678}.
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DR EMBL; LN856957; CRZ24270.1; -; Genomic_DNA.
DR RefSeq; XP_001898225.1; XM_001898190.1.
DR STRING; 6279.A0A0H5S6Q3; -.
DR EnsemblMetazoa; Bm1853.1; Bm1853.1; WBGene00222114.
DR EnsemblMetazoa; Bm1853.2; Bm1853.2; WBGene00222114.
DR GeneID; 6101666; -.
DR KEGG; bmy:BM_BM1853; -.
DR WBParaSite; Bm1853.1; Bm1853.1; WBGene00222114.
DR CTD; 6101666; -.
DR WormBase; Bm1853; BM18540; WBGene00222114; Bma-exos-4.1.
DR OrthoDB; 202892at2759; -.
DR Proteomes; UP000006672; Unassembled WGS sequence.
DR GO; GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR CDD; cd11370; RNase_PH_RRP41; 1.
DR Gene3D; 3.30.230.70; GHMP Kinase, N-terminal domain; 1.
DR InterPro; IPR001247; ExoRNase_PH_dom1.
DR InterPro; IPR036345; ExoRNase_PH_dom2_sf.
DR InterPro; IPR027408; PNPase/RNase_PH_dom_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR018336; RNase_PH_CS.
DR PANTHER; PTHR11953; EXOSOME COMPLEX COMPONENT; 1.
DR PANTHER; PTHR11953:SF0; EXOSOME COMPLEX COMPONENT RRP41; 1.
DR Pfam; PF01138; RNase_PH; 1.
DR SUPFAM; SSF55666; Ribonuclease PH domain 2-like; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS01277; RIBONUCLEASE_PH; 1.
PE 3: Inferred from homology;
KW Exosome {ECO:0000256|ARBA:ARBA00022835};
KW Reference proteome {ECO:0000313|Proteomes:UP000006672};
KW rRNA processing {ECO:0000256|ARBA:ARBA00022552}.
FT DOMAIN 18..148
FT /note="Exoribonuclease phosphorolytic"
FT /evidence="ECO:0000259|Pfam:PF01138"
SQ SEQUENCE 249 AA; 27227 MW; E4C23DC3D799DB3A CRC64;
MSIISEHGFR QDGRKPHQIR NLNYKLGVYS QADGSAYLEQ GNTKVLCAVY GPYEPKQRSR
LLEDRCIINC QYSMATFSTN ERKERPRGDR RSLEFARLME KAFEEAILTE NYPRSQIDVF
CELLQADGSH LAACVNVGTL ALADAGVPMR GLVAAASCAC APGGLACVDV NSREEMGIVP
RLTVATISGQ DAVVMAELQN RLHKNHLMVI LGNARKATAH VHSCLEAAVL THIKAAIGLP
SDSDVERDS
//
