ID A0A0H5SAW5_BRUMA Unreviewed; 685 AA.
AC A0A0H5SAW5;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Bm13815 {ECO:0000313|EMBL:CRZ25260.1};
DE SubName: Full=Elongation factor Tu GTP binding domain containing protein {ECO:0000313|WBParaSite:Bm13815.1};
GN ORFNames=Bm13815 {ECO:0000313|EMBL:CRZ25260.1,
GN ECO:0000313|WBParaSite:Bm13815.1, ECO:0000313|WormBase:Bm13815},
GN BM_Bm13815 {ECO:0000313|EMBL:CRZ25260.1};
OS Brugia malayi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6279 {ECO:0000313|EMBL:CRZ25260.1};
RN [1] {ECO:0000313|EMBL:CRZ25260.1, ECO:0000313|Proteomes:UP000006672}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CRZ25260.1,
RC ECO:0000313|Proteomes:UP000006672};
RX PubMed=17885136; DOI=10.1126/science.1145406;
RA Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E.,
RA Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T.,
RA Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.,
RA Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M.,
RA Pop M., White O., Barton G.J., Carlow C.K., Crawford M.J., Daub J.,
RA Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F.,
RA Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.W.,
RA Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA Blaxter M.L., Scott A.L.;
RT "Draft genome of the filarial nematode parasite Brugia malayi.";
RL Science 317:1756-1760(2007).
RN [2] {ECO:0000313|EMBL:CRZ25260.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CRZ25260.1};
RA Gao Y.W., Fan S.T., Sun H.T., Wang Z., Gao X.L., Li Y.G., Wang T.C.,
RA Zhang K., Xu W.W., Yu Z.J., Xia X.Z.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|WBParaSite:Bm13815.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (DEC-2019) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Classic translation factor GTPase family. IF-2 subfamily.
CC {ECO:0000256|ARBA:ARBA00007733}.
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DR EMBL; LN856998; CRZ25260.1; -; Genomic_DNA.
DR STRING; 6279.A0A0H5SAW5; -.
DR EnsemblMetazoa; Bm13815.1; Bm13815.1; WBGene00234076.
DR WBParaSite; Bm13815.1; Bm13815.1; WBGene00234076.
DR WormBase; Bm13815; BM23267; WBGene00234076; -.
DR OMA; DEIICFE; -.
DR OrthoDB; 169393at2759; -.
DR Proteomes; UP000006672; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR CDD; cd01887; IF2_eIF5B; 1.
DR CDD; cd03702; IF2_mtIF2_II; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR Gene3D; 3.40.50.10050; Translation initiation factor IF- 2, domain 3; 1.
DR InterPro; IPR044145; IF2_II.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR015760; TIF_IF2.
DR InterPro; IPR023115; TIF_IF2_dom3.
DR InterPro; IPR036925; TIF_IF2_dom3_sf.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43381:SF20; TRANSLATION INITIATION FACTOR IF-2, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43381; TRANSLATION INITIATION FACTOR IF-2-RELATED; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF11987; IF-2; 1.
DR SUPFAM; SSF52156; Initiation factor IF2/eIF5b, domain 3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 2.
DR PROSITE; PS51722; G_TR_2; 1.
PE 3: Inferred from homology;
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000006672}.
FT DOMAIN 139..308
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 685 AA; 76681 MW; 8683CBB71791427C CRC64;
MQQLMHLCAI RWLLDGSVRF VRLSPKCYVK RKRRKFIDPI VVGKTPSKKK VAEIYEDMKV
GELAKVLGSS DEEIFQVLKN INNSPRINNE KLDMSTITTV VGAFGLKPKL IPHPRSIVSE
HFELDAFPQP PPPENELRRR APIITIMGHV DHGKTTLLDC LRHSQIVESE YGGITQHIGA
FTLKEKDCEI TFLDTPGHAA FAKMRERGAH STDIVVLVVA ADDGVNEQTV QSINYAKTAN
VPIVVAINKI DKANANPIKA KQSLVEHGIL VDDLGGDVLC VEISALKGEN VDELKEAILL
QAEDMNLRST WSGLVEGIVI ESKIQSGIGK VCTMIVQRGT LVKGAALVAG TCWARVRSMH
DEFGHDLVKA IPSTPVVVSG WRENLPTPGE RVLQLENESR AQEVVRYRLK KEMNKKAEED
WKTAEQRNEK ERKEYLENRR KLLDAGLRAG STLRLIVHKE QKYQKDVGNQ KPYVRLMLNT
DVDGTLEAIL NVFDTYKSEE VELDLVKFDV GPPSESDVKL AKDLGILLYC FNVQVPLGVK
RTAEQLGVEI SCFNVIYRLV EDLKSRLSNC LPEEVTMEQV GEGHVIKSFS VIVERKKQSI
GGILVDWGTI NKSDLLRVLR DTTVIFEGSI RSMRVGTQVV SSASKNEEVG VAVSNDKIVF
KEDDIVETYR EKKVKRQISW DPPGF
//
