ID A0A0H5SPG7_BRUMA Unreviewed; 543 AA.
AC A0A0H5SPG7;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=bma-pak-2 {ECO:0000313|WormBase:Bm2776};
GN Synonyms=Bma-pak-2 {ECO:0000313|EMBL:CRZ25512.1,
GN ECO:0000313|WBParaSite:Bm2776.1};
GN ORFNames=Bm2776 {ECO:0000313|WormBase:Bm2776}, BM_Bm2776
GN {ECO:0000313|EMBL:CRZ25512.1};
OS Brugia malayi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6279 {ECO:0000313|EMBL:CRZ25512.1};
RN [1] {ECO:0000313|EMBL:CRZ25512.1, ECO:0000313|Proteomes:UP000006672}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CRZ25512.1,
RC ECO:0000313|Proteomes:UP000006672};
RX PubMed=17885136; DOI=10.1126/science.1145406;
RA Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E.,
RA Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T.,
RA Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.,
RA Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M.,
RA Pop M., White O., Barton G.J., Carlow C.K., Crawford M.J., Daub J.,
RA Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F.,
RA Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.W.,
RA Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA Blaxter M.L., Scott A.L.;
RT "Draft genome of the filarial nematode parasite Brugia malayi.";
RL Science 317:1756-1760(2007).
RN [2] {ECO:0000313|EMBL:CRZ25512.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CRZ25512.1};
RA Gao Y.W., Fan S.T., Sun H.T., Wang Z., Gao X.L., Li Y.G., Wang T.C.,
RA Zhang K., Xu W.W., Yu Z.J., Xia X.Z.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|WBParaSite:Bm2776.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (DEC-2019) to UniProtKB.
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DR EMBL; LN857010; CRZ25512.1; -; Genomic_DNA.
DR STRING; 6279.A0A0H5SPG7; -.
DR EnsemblMetazoa; Bm2776.1; Bm2776.1; WBGene00223037.
DR WBParaSite; Bm2776.1; Bm2776.1; WBGene00223037.
DR WormBase; Bm2776; BM16446; WBGene00223037; Bma-pak-2.
DR OMA; FEHRYHA; -.
DR OrthoDB; 460351at2759; -.
DR Proteomes; UP000006672; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0002119; P:nematode larval development; IEA:EnsemblMetazoa.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd01093; CRIB_PAK_like; 1.
DR CDD; cd06648; STKc_PAK_II; 1.
DR Gene3D; 3.90.810.10; CRIB domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR000095; CRIB_dom.
DR InterPro; IPR036936; CRIB_dom_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR033923; PAK_BD.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR PANTHER; PTHR48015; SERINE/THREONINE-PROTEIN KINASE TAO; 1.
DR PANTHER; PTHR48015:SF4; SERINE_THREONINE-PROTEIN KINASE PAK MBT; 1.
DR Pfam; PF00786; PBD; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00285; PBD; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50108; CRIB; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Reference proteome {ECO:0000313|Proteomes:UP000006672}.
FT DOMAIN 12..25
FT /note="CRIB"
FT /evidence="ECO:0000259|PROSITE:PS50108"
FT DOMAIN 270..521
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 213..234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 300
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 543 AA; 61627 MW; 2D0E7FC779B4562D CRC64;
MSIRRRTKKV DISMPTNFEH RYHAGFDPVT GQYHGLPKQW QAIIGITPNR RGRPRPMVDP
SCITPMEIAE IKTVVRGDVP QSYHKEINFG GMPMSSKLRK DRNNLQDGVR NDFTRTLPIS
DAWTSLHQPM QPRRHAQQHL SVNFQRPNPV EMNLPRTSTW HNGLLQSVHL KQNSSYSTQC
DLANAVEVYP ENYALLQQSN LLYSSGLQVE MNPRPSTLTH NEASAYRPNN STMHNNIRQK
RDQSHNRLSH DEFRAALKLV VLPGDPRADL TNYTQIGEGS TGTVVTAHQI STGRKIAIKK
MNILKQQRRE LLFNEVLIMR DYEHPNVVEM YGSYLVGDEL WVLMEYMEGG ALTDIITQMR
IDEPAIATIC VQCLKALEYL HSKGVVHRDI KSDSILLTKD GVAKISDFGF CGQLSVDIPQ
RRSLVGTPYW MSPEVISRLP YGTEADIWSL GIMVIEMVQG EPPLFNVQPL QAMKMIRDNG
PPKINEPVNV SPELASFISQ MLVRDVKQRA TASQLLNHEF LKKACDPSVI CSMMNITRNL
ETV
//
