ID A0A0I9N7W1_BRUMA Unreviewed; 781 AA.
AC A0A0I9N7W1;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=BMA-MML-1 {ECO:0000313|EMBL:CTP80812.1, ECO:0000313|WBParaSite:Bm8689a.1};
GN Name=Bma-mml-1 {ECO:0000313|EMBL:CTP80812.1,
GN ECO:0000313|WBParaSite:Bm8689a.1};
GN ORFNames=BM_Bm8689 {ECO:0000313|EMBL:CTP80812.1};
OS Brugia malayi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6279 {ECO:0000313|EMBL:CTP80812.1};
RN [1] {ECO:0000313|EMBL:CTP80812.1, ECO:0000313|Proteomes:UP000006672}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CTP80812.1,
RC ECO:0000313|Proteomes:UP000006672};
RX PubMed=17885136; DOI=10.1126/science.1145406;
RA Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E.,
RA Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T.,
RA Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.,
RA Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M.,
RA Pop M., White O., Barton G.J., Carlow C.K., Crawford M.J., Daub J.,
RA Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F.,
RA Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.W.,
RA Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA Blaxter M.L., Scott A.L.;
RT "Draft genome of the filarial nematode parasite Brugia malayi.";
RL Science 317:1756-1760(2007).
RN [2] {ECO:0000313|EMBL:CTP80812.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CTP80812.1};
RA Gao Y.W., Fan S.T., Sun H.T., Wang Z., Gao X.L., Li Y.G., Wang T.C.,
RA Zhang K., Xu W.W., Yu Z.J., Xia X.Z.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|WBParaSite:Bm8689a.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (DEC-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; LN856551; CTP80812.1; -; Genomic_DNA.
DR STRING; 6279.A0A0I9N7W1; -.
DR EnsemblMetazoa; Bm8689a.1; Bm8689a.1; WBGene00228950.
DR WBParaSite; Bm8689a.1; Bm8689a.1; WBGene00228950.
DR OMA; PDIFMNY; -.
DR OrthoDB; 2963550at2759; -.
DR Proteomes; UP000006672; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR CDD; cd21739; NES2-NLS_ChREBP-like; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR PANTHER; PTHR15741; BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR; 1.
DR PANTHER; PTHR15741:SF37; LD38259P; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000006672};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 584..637
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 286..341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 533..563
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 627..668
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 291..341
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 533..551
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 781 AA; 88405 MW; 454E9BF243A44811 CRC64;
MSSESPSHEP IHSGHFMTSN PHSDEMLPDE EVVGVVVEDD VVEQDAEQKG QDLCDLNVQD
EKPVTFYKFG PKRTQSIAID VSLNKLNKCI KVAYNKMTTP KWKDFKGLRL HWKQRIRLNN
VIWRAYYMEF RRPDKDKSRR TPYCYFTVPD DDSTHVKFTG TVVEGMYWKR SMDALKAQYK
RWRHSRTRRR GRRRGISWNQ EISSVPQLAV QNSMIKNSSA EQPDTDDLDN EFTDTLFANL
MQPYTFPDPK EITQGCNADV MQPGLLSLQP SIEEIMASLD PPDQLLDEIG NYGASNVSPT
SPCTPKEYEA TFSNNFTNPT QQQQQQQQQQ QQQPTRQSSS ISPQILLANS SAPTYSQAAY
DHTPLIATMP YTTDSSNLDY VPQFLTTTMQ FPSSVLPNRT WWMNFPSTPT PSLLNSPSTP
SIVLSPSSSS TTGVLSLSVN SPTTISTVET HLINTSSKNS IKIFPAPTDT LKLETERWNN
TVLSSLSREI TTDSTEHGAW KQLPSTANTA SQNSLLIPQP VYPQQNSQII PKVTESSSHE
QSTLLSASTA SIKQEHEKEE RIHRVQKRGC RSVAADSTIE PVERKRILHL NAEQNRRCAL
KDGFEQLLNS LPNLYGCGTK PTNAIVLTRA AERIRQLKAE IALNEEKTKQ LKQSIQRLND
KIVSLQASLP SSSRTAVSTI SQKAEMEQFL ERYTKERTRQ DYRFWVMAKM MQPLTETLIE
RLSQLPSNRA LAETSDWLQT NFQLSTVRAN ASSLLVYLAT HAGMLNDPNA LQECIQRELS
Q
//
