ID A0A0I9N9B8_BRUMA Unreviewed; 639 AA.
AC A0A0I9N9B8; A0A0K0JAL5;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Bm3514 {ECO:0000313|EMBL:CTP81283.1};
DE SubName: Full=Caspase family p20 domain-containing protein {ECO:0000313|WBParaSite:Bm3514a.1};
GN Name=Bma-malt-1 {ECO:0000313|WBParaSite:Bm3514a.1};
GN ORFNames=Bm3514 {ECO:0000313|EMBL:CTP81283.1}, BM_Bm3514
GN {ECO:0000313|EMBL:CTP81283.1};
OS Brugia malayi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6279 {ECO:0000313|EMBL:CTP81283.1};
RN [1] {ECO:0000313|EMBL:CTP81283.1, ECO:0000313|Proteomes:UP000006672}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CTP81283.1,
RC ECO:0000313|Proteomes:UP000006672};
RX PubMed=17885136; DOI=10.1126/science.1145406;
RA Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E.,
RA Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T.,
RA Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.,
RA Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M.,
RA Pop M., White O., Barton G.J., Carlow C.K., Crawford M.J., Daub J.,
RA Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F.,
RA Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.W.,
RA Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA Blaxter M.L., Scott A.L.;
RT "Draft genome of the filarial nematode parasite Brugia malayi.";
RL Science 317:1756-1760(2007).
RN [2] {ECO:0000313|EMBL:CTP81283.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CTP81283.1};
RA Gao Y.W., Fan S.T., Sun H.T., Wang Z., Gao X.L., Li Y.G., Wang T.C.,
RA Zhang K., Xu W.W., Yu Z.J., Xia X.Z.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|WBParaSite:Bm3514a.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (DEC-2019) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase C14A family.
CC {ECO:0000256|ARBA:ARBA00010134}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LN856962; CTP81283.1; -; Genomic_DNA.
DR STRING; 6279.A0A0I9N9B8; -.
DR EnsemblMetazoa; Bm3514a.1; Bm3514a.1; WBGene00223775.
DR WBParaSite; Bm3514a.1; Bm3514a.1; WBGene00223775.
DR OMA; EVNGVFM; -.
DR OrthoDB; 3080800at2759; -.
DR Proteomes; UP000006672; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.40.50.1460; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR029030; Caspase-like_dom_sf.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR011600; Pept_C14_caspase.
DR InterPro; IPR001309; Pept_C14_p20.
DR InterPro; IPR015917; Pept_C14A.
DR PANTHER; PTHR22576:SF37; MALT1 PARACASPASE HOMOLOG; 1.
DR PANTHER; PTHR22576; MUCOSA ASSOCIATED LYMPHOID TISSUE LYMPHOMA TRANSLOCATION PROTEIN 1/PARACASPASE; 1.
DR Pfam; PF00656; Peptidase_C14; 1.
DR SMART; SM00115; CASc; 1.
DR SUPFAM; SSF52129; Caspase-like; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50208; CASPASE_P20; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000006672}.
FT DOMAIN 260..388
FT /note="Caspase family p20"
FT /evidence="ECO:0000259|PROSITE:PS50208"
SQ SEQUENCE 639 AA; 72144 MW; E433A739562DA862 CRC64;
MSSVASLQEY DLSTNLAELP IGLHWRLASS LNFQTVWMKV IGDSTSSPFS LSVSEYDRIL
RSENQGSSLL YLWGNRGQNV RHLLLRLQSF SKMHGTSLDG PQLALRRKFV PVKWSADEQI
TVKVIGADNC MLQLFCHARG FPWPHFQWME NDKDIDCSNG KALIISRCKC RKGLMYRCRI
WNEIEEGFEY STFYRRPGKS FHSKLITKPV DLSLFITANV TVDSCKRCSA YKNLNLSTDF
FRTVQNEGNI GGWNAELIAT DKVALIIGNC NYINLPSLVT PHCDAEMFAE SLQNLGFKTV
ALGDLNLAEM HFFIKEYRKL LGDGVYAVFY FVGHGFEKNG KNYLLAVDAP SVDCKMTECI
SVEWVLSVFE DSHPALNLIL LDVCRKNVKC VGCLDDADNE QIPKIARNTV CGYATSSGVS
AFEVHGERNG VFMKHLLQHI ADEATVLEML TKTFQEISND TRICDVQIPE LKSNLVLPRG
LRDPLICYGH TASFNCHTLY WRYMHELPSP INVQFTDQNM FVIIWYDYVG HFTNKVYIFT
SVNDLSDKNS AGGLKPLPTK FSHVAHLHFP KHVDVSAERI IEDGNDGVSI SVMLSNLQRL
KGTVLFSVDL ASRKDDVVIA SKSNLSLGDV LVTRIYRVE
//
