ID A0A0I9NA64_BRUMA Unreviewed; 807 AA.
AC A0A0I9NA64;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=BMA-GBB-2 {ECO:0000313|EMBL:CTP82030.1, ECO:0000313|WBParaSite:Bm7432a.1};
GN Name=Bma-gbb-2 {ECO:0000313|EMBL:CTP82030.1,
GN ECO:0000313|WBParaSite:Bm7432a.1};
GN ORFNames=BM_Bm7432 {ECO:0000313|EMBL:CTP82030.1};
OS Brugia malayi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6279 {ECO:0000313|EMBL:CTP82030.1};
RN [1] {ECO:0000313|EMBL:CTP82030.1, ECO:0000313|Proteomes:UP000006672}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CTP82030.1,
RC ECO:0000313|Proteomes:UP000006672};
RX PubMed=17885136; DOI=10.1126/science.1145406;
RA Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E.,
RA Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T.,
RA Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.,
RA Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M.,
RA Pop M., White O., Barton G.J., Carlow C.K., Crawford M.J., Daub J.,
RA Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F.,
RA Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.W.,
RA Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA Blaxter M.L., Scott A.L.;
RT "Draft genome of the filarial nematode parasite Brugia malayi.";
RL Science 317:1756-1760(2007).
RN [2] {ECO:0000313|EMBL:CTP82030.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CTP82030.1};
RA Gao Y.W., Fan S.T., Sun H.T., Wang Z., Gao X.L., Li Y.G., Wang T.C.,
RA Zhang K., Xu W.W., Yu Z.J., Xia X.Z.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|WBParaSite:Bm7432a.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (DEC-2019) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; LN857024; CTP82030.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0I9NA64; -.
DR STRING; 6279.A0A0I9NA64; -.
DR EnsemblMetazoa; Bm7432a.1; Bm7432a.1; WBGene00227693.
DR WBParaSite; Bm7432a.1; Bm7432a.1; WBGene00227693.
DR InParanoid; A0A0I9NA64; -.
DR OMA; DACTNVN; -.
DR OrthoDB; 2970339at2759; -.
DR Proteomes; UP000006672; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004965; F:G protein-coupled GABA receptor activity; IEA:EnsemblMetazoa.
DR GO; GO:0032223; P:negative regulation of synaptic transmission, cholinergic; IEA:EnsemblMetazoa.
DR GO; GO:0040012; P:regulation of locomotion; IEA:EnsemblMetazoa.
DR GO; GO:0009410; P:response to xenobiotic stimulus; IEA:EnsemblMetazoa.
DR CDD; cd06366; PBP1_GABAb_receptor; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR002455; GPCR3_GABA-B.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR10519; GABA-B RECEPTOR; 1.
DR PANTHER; PTHR10519:SF20; GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 2; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR PRINTS; PR01177; GABAB1RECPTR.
DR PRINTS; PR01176; GABABRECEPTR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000006672};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..807
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013453824"
FT TRANSMEM 451..477
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 497..514
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 534..551
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 572..593
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 626..648
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 668..686
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 692..713
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 463..724
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 807 AA; 92512 MW; FBD510B46ACC5A0E CRC64;
MHCLICPLLM AQIWFGYSQD CQRLRRVNRI PLTIGVFLPY QYKRVLEPAV NIALEHIHNQ
SCILNDYYLK LHFKDTECKT SFGMKALFEL MNARPRPFAL FGDACTNVNE VVAMASKYWH
ILHLSYAEIH AKFATADAQA MYPTFFRMVP GYQNSNLARC HLIFQFNWTR VGTLKQSDDP
RFALPHESLT TRLEHGFGIR VIYTAGITHD EIQNIGYELN ELKKRDARIL IGDFEESLAV
RILCEAYQNG IYGENYAWIL PGYHKSDWWR NASGVSCTVE ELAKVIEGHF AVEFSPYSQR
LARLTIANKT VSAIRTELDD RQGSSPESVF KGYVYDGLWT LSLAIEHVAQ LHQQRDGITW
IPNVSDTEDW TKLSVELLQA ISSTSFIGVT GPVRFENNER LGLVEILQWR NGSYMIAGIY
DGTKAVLTLN PALRDWTPPL DATVVVRERQ YISFVLFIFL SLLAIIGVAI AVFFLIINIR
YQNHRYIKMS SPNMNNLIIA GSICTYISVI LLGFDTRFVS PDTFVTLCYV KTWVLSLGFT
LAFGSMFSKT WRVHLIFKNI RMNKKAIKDY KLFMLVGFIV LVDLVSLALW ARISPFTFHV
NQLAIFYSDN KMIAPEIERC RSDNSVIFEA IILGIKGLLM LLGCFLAWET RRVNVPALND
SKYIGMSVYS VVVTCLLGLP LVYILKDRVN EAHILGSLFI IFCTTLILCL VFVPKIVELL
RNPQGTELRY RRGLVKSTLG RSESQQTSQH NDATNIFRRE HLQRLEEENI LLHRYLLQKT
SILWELQEQL RQLGELEDDD TITSPSD
//
