ID   A0A0I9U2E2_9MYCO        Unreviewed;       902 AA.
AC   A0A0I9U2E2;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   SubName: Full=Polyketide synthase {ECO:0000313|EMBL:KLO36201.1};
DE   Flags: Fragment;
GN   ORFNames=ABH38_13520 {ECO:0000313|EMBL:KLO36201.1};
OS   Mycobacterium haemophilum.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=29311 {ECO:0000313|EMBL:KLO36201.1, ECO:0000313|Proteomes:UP000036334};
RN   [1] {ECO:0000313|EMBL:KLO36201.1, ECO:0000313|Proteomes:UP000036334}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UC1 {ECO:0000313|Proteomes:UP000036334};
RA   Greninger A.L., Cunningham G., Miller S.;
RT   "Genome sequence of Mycobacterium haemophilum.";
RL   Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KLO36201.1}.
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DR   EMBL; LDPR01000010; KLO36201.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0I9U2E2; -.
DR   OrthoDB; 9778690at2; -.
DR   Proteomes; UP000036334; Unassembled WGS sequence.
DR   GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR   CDD; cd00833; PKS; 1.
DR   Gene3D; 3.40.47.10; -; 1.
DR   Gene3D; 3.30.70.250; Malonyl-CoA ACP transacylase, ACP-binding; 1.
DR   Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR   InterPro; IPR001227; Ac_transferase_dom_sf.
DR   InterPro; IPR014043; Acyl_transferase.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR018201; Ketoacyl_synth_AS.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR   InterPro; IPR032821; PKS_assoc.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR   Pfam; PF00698; Acyl_transf_1; 1.
DR   Pfam; PF16197; KAsynt_C_assoc; 1.
DR   Pfam; PF00109; ketoacyl-synt; 1.
DR   Pfam; PF02801; Ketoacyl-synt_C; 1.
DR   SMART; SM00827; PKS_AT; 1.
DR   SMART; SM00825; PKS_KS; 1.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR   SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 1.
DR   PROSITE; PS00606; KS3_1; 1.
DR   PROSITE; PS52004; KS3_2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000036334}.
FT   DOMAIN          34..462
FT                   /note="Ketosynthase family 3 (KS3)"
FT                   /evidence="ECO:0000259|PROSITE:PS52004"
FT   NON_TER         902
FT                   /evidence="ECO:0000313|EMBL:KLO36201.1"
SQ   SEQUENCE   902 AA;  94951 MW;  043A10E7022D7F6B CRC64;
     MTAATPDRRA IITEALHKID DLTARLEIAE KSSTEPIAVI GMGCRFPGGV NNPEQFWDLL
     RDGRNGIVRV PADRWDADAY YTDDHTVPGT ICSTEGGFLT GWQPDEFDAE FFSISPREAS
     AMDPQQRLLI EVAWEALEDA GVQPHTIRGT QTSVFVGVTA YDYMLTLAGR LRPEDLDAYI
     PTGNSANFAA GRLAYILGAR GPAVVIDTAC SSSLVAVHLA CQSLRSRESD TALVGGTNLL
     LSPGPSIACS RWGMLSPEGQ CKTFDVSADG YVRGEGAGVV VLKRLDDAVR DGNRILAVVR
     GSAVNQDGAS SGVTVPNGPA QQELLRTALA SSKLAAADID YIEAHGTGTP LGDPIELDSL
     SKVFNDREGS APLVIGSVKT NLGHLEAAAG VAGLMKAVLA IRNGYIPRHL NFHQLTTHAS
     EAAVRLNIAA EGLEWPTTGR PRRAGVSSFG VSGTNAHVVL EQAPAPVAAP GSQPSPDPAV
     STLVVSGKTV QRVAATASVL ADWMEGPGAA VPLADVAHTL NHHRARHTKF GTVAAVDRGQ
     AVAGLRALAA GQSASGVVAP RDSAVGPGTV FVYSGRGSQW AGMGRQLLAD EPAFAEAIAT
     LEPEFVAQAG FSLHDVLANG KELVGIEQIQ LGLMGMQLAL TELWRSYGVE PDAVIGHSMG
     EVAAAVVAGA LTPAQGLRVT ATRSRLMAPL SGQGTMALLE LDAAATETLI ADYPQVSLGI
     YASPRQTVIA GPTAMIDALI DKVRQQDGFA TRVNIEVAPH NPAMDALQPQ MRSELADLTP
     QPPTIPIIST TYEDLSSTPI FDAEHWATNM RNPVRFQQAI THASSGIGGD YHTFIEISAH
     PLLTHSISDI VRSIDGAADE NTVSAGYLSI GTLQRDAHDT LEFHTNLNAT HTSRPPRTPH
     PC
//