ID A0A0I9UH22_9MYCO Unreviewed; 358 AA.
AC A0A0I9UH22;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=DNA ligase (ATP) {ECO:0000256|ARBA:ARBA00012727};
DE EC=6.5.1.1 {ECO:0000256|ARBA:ARBA00012727};
GN Name=ligC {ECO:0000313|EMBL:KLO34582.1};
GN ORFNames=ABH38_18460 {ECO:0000313|EMBL:KLO34582.1};
OS Mycobacterium haemophilum.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=29311 {ECO:0000313|EMBL:KLO34582.1, ECO:0000313|Proteomes:UP000036334};
RN [1] {ECO:0000313|EMBL:KLO34582.1, ECO:0000313|Proteomes:UP000036334}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UC1 {ECO:0000313|Proteomes:UP000036334};
RA Greninger A.L., Cunningham G., Miller S.;
RT "Genome sequence of Mycobacterium haemophilum.";
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-
CC (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP +
CC diphosphate.; EC=6.5.1.1; Evidence={ECO:0000256|ARBA:ARBA00034003};
CC -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC {ECO:0000256|ARBA:ARBA00007572}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KLO34582.1}.
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DR EMBL; LDPR01000024; KLO34582.1; -; Genomic_DNA.
DR RefSeq; WP_047316484.1; NZ_LDPT01000028.1.
DR AlphaFoldDB; A0A0I9UH22; -.
DR STRING; 1202450.B586_03565; -.
DR PATRIC; fig|29311.18.peg.2580; -.
DR OrthoDB; 9770771at2; -.
DR Proteomes; UP000036334; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR CDD; cd07905; Adenylation_DNA_ligase_LigC; 1.
DR CDD; cd07970; OBF_DNA_ligase_LigC; 1.
DR Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR044119; Adenylation_LigC-like.
DR InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR044117; OBF_LigC-like.
DR PANTHER; PTHR45674; DNA LIGASE 1/3 FAMILY MEMBER; 1.
DR PANTHER; PTHR45674:SF9; DNA LIGASE 3; 1.
DR Pfam; PF04679; DNA_ligase_A_C; 1.
DR Pfam; PF01068; DNA_ligase_A_M; 1.
DR SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE 3: Inferred from homology;
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:KLO34582.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000036334}.
FT DOMAIN 105..252
FT /note="ATP-dependent DNA ligase family profile"
FT /evidence="ECO:0000259|PROSITE:PS50160"
SQ SEQUENCE 358 AA; 40083 MW; 6F0F0E0E1E30BBAA CRC64;
MDLPVMPPVS PMLAKSVRSI PANASYEPKW DGFRSICFRD GDQVELGSRN ERPMTRYFPE
LVAAATAELP KRCVIDGEIV IATDHGLDFE ALQQRIHPAD SRVRMLAERT PASFIAFDLL
ALGDDDYTER PFSERRSALV DALAVSAADS AASIHVTPAT TDRATAQRWF AQFEGAGLDG
LVAKPLTITY QPDKRVMFKI KHERTADCVV AGYRVHKSDT DAIGSLLLGL YQDDGQLASV
GVIGAFPMAE RRQLFTELQP LVTGFDGHPW NWAAHKAGER TPRKNETSRW NTGKDLSFVP
LLPERVVEVR YDHMEGRRFR HTAQFSRWRP DRDPRSCTYD QLEQPLTFSL SDIVPGLA
//
