ID A0A0I9VK63_9MYCO Unreviewed; 1069 AA.
AC A0A0I9VK63;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=ABH38_01615 {ECO:0000313|EMBL:KLO39074.1};
OS Mycobacterium haemophilum.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=29311 {ECO:0000313|EMBL:KLO39074.1, ECO:0000313|Proteomes:UP000036334};
RN [1] {ECO:0000313|EMBL:KLO39074.1, ECO:0000313|Proteomes:UP000036334}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UC1 {ECO:0000313|Proteomes:UP000036334};
RA Greninger A.L., Cunningham G., Miller S.;
RT "Genome sequence of Mycobacterium haemophilum.";
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KLO39074.1}.
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DR EMBL; LDPR01000001; KLO39074.1; -; Genomic_DNA.
DR RefSeq; WP_047313270.1; NZ_LDPT01000001.1.
DR AlphaFoldDB; A0A0I9VK63; -.
DR STRING; 1202450.B586_17090; -.
DR PATRIC; fig|29311.18.peg.352; -.
DR OrthoDB; 5240387at2; -.
DR Proteomes; UP000036334; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF59; DNA HELICASE; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000036334}.
FT DOMAIN 4..331
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 317..627
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 25..32
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1069 AA; 112335 MW; 06CD6991D482DC82 CRC64;
MSYTWGGEAR AVLEPGARGL IRILGGPGTG KSSLLVGAAV AHIGAGVEPE SVLLLTGSGR
LGIPARSALT TALLRSRTTG RCRAAVCEPL VRTVHSYAYA VLRRAAERAG DAPPRLVTSA
EQDAIIRELL AGDLADGPHA ATIWPAHLLP ALSTAGFAIE LRNLLARCAE RGVDALELER
LGRVCRRPEW TAAGQFAKQY EQVMLLRAAV GTAAPQATTP ALGAAELVGA ALEAFAVDPE
LLAAERTRVR LLLVDDAQQL DPQAARLVRV LAAGTELALV AGDPNQAVFS FRGGEPAGLL
ADDAPSVTLT ASHRCAPAVA RAVSGVACRL PGGIGGRQID GTGAEDGSVT VRLAASAHAE
ASIIADTLRR AHLIDGVPWS QMVVIVRSVP RAGARLPRGL AAAGVPVAVP AVRGPLSAEP
VAQALLTVLA ATAAGLDGEQ ALALLTGPIG RVDPVSLRQL RRSLLHGNPD RRWANFGDLL
VEALFPASGW GHLPLAGEYP HAGAPVSGAQ SGPLQRVRAV LDAAAGCHRD GKDPRYTLWA
AWHRSGLQHR LLTASERGGP AGAQATRDLE TVTALFDITD HYVCHTSGAS LRGLVEHVAA
LQLPTVSREP VTTTEQVRVL SAHAALGHEW DVVVIAGMQD GLWPNTVPRG GVLGTQRLLD
VLDGVTEDAS MRAPLLAEER RLLVAAMGRA RRRLLVTAVD SDTDGPGLGA ALPSAFFYEI
AKWATGDSDP EVAQPVSSPR VLSAAALVGR LRGVVCAPDG AVDDAARACA ATQLARLANA
GVPGADPTGW HGLIPLSSSD RLCGDNDLVT LTPSTLQTLN DCPLRWLAER HGGTNARDLR
SAIGSVLHAL IAEPDKSESQ LLAELDRAWQ HLPFDAQWHS VNELARHRAM IQTFVEWRAQ
TRHELTEVGV EVDVDGMLGD PRESEHQAGD ARLRGRVDRL ERDSAGRLVI VDIKTGKTPV
SKDDAQQHAQ LAMYQLAVAD GMFSAGPASM EPGGARLVYL GRTGPAGAVE REQDPLTPAD
RDHWRNVVRQ AANATAGPQF IARRNDGCAH CPIRPCCPAH GEHVEGAAL
//