ID A0A0J0V0R3_9ACTN Unreviewed; 622 AA.
AC A0A0J0V0R3;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Cell division protein FtsI/penicillin-binding protein 2 {ECO:0000313|EMBL:KLR62615.1};
GN ORFNames=IMCC26207_102108 {ECO:0000313|EMBL:KLR62615.1};
OS Actinobacteria bacterium IMCC26207.
OC Bacteria; Actinomycetota; Actinomycetes.
OX NCBI_TaxID=1641811 {ECO:0000313|EMBL:KLR62615.1, ECO:0000313|Proteomes:UP000036180};
RN [1] {ECO:0000313|EMBL:KLR62615.1, ECO:0000313|Proteomes:UP000036180}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IMCC26207 {ECO:0000313|EMBL:KLR62615.1,
RC ECO:0000313|Proteomes:UP000036180};
RA Kim S., Cho J.-C.;
RT "Genome sequence of freshwater Actinobacteria.";
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KLR62615.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LCZK01000002; KLR62615.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0J0V0R3; -.
DR STRING; 1641811.IMCC26207_102108; -.
DR Proteomes; UP000036180; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR Gene3D; 3.30.450.330; -; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF1; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000313|EMBL:KLR62615.1};
KW Cell division {ECO:0000313|EMBL:KLR62615.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000036180};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 35..195
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 241..551
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT REGION 567..622
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 567..600
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 622 AA; 65162 MW; C078784263D693EE CRC64;
MLAVLPLIKL VSVQLGSGAE LAARGESQRV RTVVLPAARG SILDRSGAEM AISLPRYRVV
TNMKVLAGEG ISTSTDLERL AERIAPVMKL DRTELTQTLL KADASDPWVR LAETVSIEDA
DRAVALLKKD GIENVLTLED SSERVHPAGD SALRLLGTVG PEGPGKLAGI ERAYDSELQG
KPGKKVLELG TKGESILGGE HLLQEPAAGS SVQLTLDRSI QHETERMLAE GAAHAGAHKG
IAIIGRPGSG EILAVASVER DPETSKMRLS SGPIAFSDSY QAGSVFKLVT VAAAVESGQV
TPETVLQVPY RLQVADKLFS DHEAHPTEPM TVTEILAQSS NVGTIKVALG MGKQSLHDAL
TGFGFGSSTG SGHPAEASGI VPRVSDWTTP DLAASAIGTH QSATAIQIWA AYNVIANKGR
YVSPRLVGSV IAADGSRTTP PAKPSRDVIS ASSAEQVSEM LQQVVRDGTG KQWSIPGYPI
AAKTGTSRMA AETQLDKADG YAWADGRYHY LAAFTGFLPA ERPQVSITVI LDDITPGLTG
STAAGPVFSD LAHLSIRELG IAPTNQADVS EDSTQQTDPS AASSVPSTAV PPTTTRDANG
RVRAQPAARL ISSSGLKKTE KR
//
