ID A0A0J0XNR4_9TREE Unreviewed; 470 AA.
AC A0A0J0XNR4;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Pseudouridine synthase {ECO:0000313|EMBL:KLT42722.1};
GN ORFNames=CC85DRAFT_245506 {ECO:0000313|EMBL:KLT42722.1};
OS Cutaneotrichosporon oleaginosum.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Trichosporonales; Trichosporonaceae; Cutaneotrichosporon.
OX NCBI_TaxID=879819 {ECO:0000313|EMBL:KLT42722.1, ECO:0000313|Proteomes:UP000053611};
RN [1] {ECO:0000313|EMBL:KLT42722.1, ECO:0000313|Proteomes:UP000053611}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IBC0246 {ECO:0000313|EMBL:KLT42722.1,
RC ECO:0000313|Proteomes:UP000053611};
RG DOE Joint Genome Institute;
RA Kourist R., Kracht O., Bracharz F., Lipzen A., Nolan M., Ohm R.,
RA Grigoriev I., Sun S., Heitman J., Bruck T., Nowrousian M.;
RT "Genomics and transcriptomics of the oil-accumulating basidiomycete yeast
RT T. oleaginosus allow insights into substrate utilization and the diverse
RT evolutionary trajectories of mating systems in fungi.";
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the tRNA pseudouridine synthase TruA family.
CC {ECO:0000256|ARBA:ARBA00009375}.
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DR EMBL; KQ087202; KLT42722.1; -; Genomic_DNA.
DR RefSeq; XP_018279213.1; XM_018420355.1.
DR AlphaFoldDB; A0A0J0XNR4; -.
DR STRING; 879819.A0A0J0XNR4; -.
DR GeneID; 28980958; -.
DR OrthoDB; 12038at2759; -.
DR Proteomes; UP000053611; Unassembled WGS sequence.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0031119; P:tRNA pseudouridine synthesis; IEA:InterPro.
DR CDD; cd02568; PseudoU_synth_PUS1_PUS2; 1.
DR Gene3D; 3.30.70.660; Pseudouridine synthase I, catalytic domain, C-terminal subdomain; 1.
DR Gene3D; 3.30.70.580; Pseudouridine synthase I, catalytic domain, N-terminal subdomain; 1.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR InterPro; IPR001406; PsdUridine_synth_TruA.
DR InterPro; IPR020097; PsdUridine_synth_TruA_a/b_dom.
DR InterPro; IPR020095; PsdUridine_synth_TruA_C.
DR InterPro; IPR041708; PUS1/PUS2-like.
DR InterPro; IPR020094; TruA/RsuA/RluB/E/F_N.
DR NCBIfam; TIGR00071; hisT_truA; 1.
DR PANTHER; PTHR11142; PSEUDOURIDYLATE SYNTHASE; 1.
DR PANTHER; PTHR11142:SF4; PSEUDOURIDYLATE SYNTHASE 1 HOMOLOG; 1.
DR Pfam; PF01416; PseudoU_synth_1; 1.
DR SUPFAM; SSF55120; Pseudouridine synthase; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Reference proteome {ECO:0000313|Proteomes:UP000053611};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT DOMAIN 229..333
FT /note="Pseudouridine synthase I TruA alpha/beta"
FT /evidence="ECO:0000259|Pfam:PF01416"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 419..470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 455..470
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 84
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR641708-1"
FT BINDING 146
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR641708-2"
SQ SEQUENCE 470 AA; 52843 MW; 556289D3A5CF6963 CRC64;
MNAEAPVAKT EEDGTPKEKR LPKKRAAVLV GYCGTGYHGM QIQPHDPLTI EGDIFSALAK
AGAVSPENAV DHKKVDVQRA ARTDAGVHAA GNCISLKMIL DPPVPPEFPD LTAYVNSFLP
AQIRMWGFVR AMKSFQARTA CDSRVYEYLL PSYCLLPPAS TDPFAQTLDE TSPGWKEPLK
QALEFVDAAP PLTAGAEGEE LDPKLRGEFE RRRGWRVDEE TLKRFDALIQ QYKGTHNFHN
YTVYKAFDDR SVKRYMIRLD VRPPAVYGEI EWISVQIHGQ SFMLHQIRKM ISMAILACRT
GTPPSLIPET FGPKRIHIPK APPLGLLLEQ PQFKVYNERT RSIPNPDGEP REIVDFSKHA
EEMQAFKVKW IYDALRQTEL ETNTYHKWLK QIDHGSTKDF TYLNTRGVIP DEACQNLTSK
KYGGPGGQPV KRSLEGEAEG EEGGAKEEVD SDDEDKEIDR RALESGEFDS
//
