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Database: UniProt
Entry: A0A0J0Y180_9SPHI
LinkDB: A0A0J0Y180_9SPHI
Original site: A0A0J0Y180_9SPHI 
ID   A0A0J0Y180_9SPHI        Unreviewed;       436 AA.
AC   A0A0J0Y180;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   05-DEC-2018, entry version 14.
DE   RecName: Full=UDP-glucose 6-dehydrogenase {ECO:0000256|PIRNR:PIRNR000124};
DE            EC=1.1.1.22 {ECO:0000256|PIRNR:PIRNR000124};
GN   ORFNames=AB669_18215 {ECO:0000313|EMBL:KLT64002.1};
OS   Pedobacter sp. BMA.
OC   Bacteria; Bacteroidetes; Sphingobacteriia; Sphingobacteriales;
OC   Sphingobacteriaceae; Pedobacter.
OX   NCBI_TaxID=1663685 {ECO:0000313|EMBL:KLT64002.1, ECO:0000313|Proteomes:UP000036014};
RN   [1] {ECO:0000313|EMBL:KLT64002.1, ECO:0000313|Proteomes:UP000036014}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BMA {ECO:0000313|EMBL:KLT64002.1,
RC   ECO:0000313|Proteomes:UP000036014};
RA   Anderson B.M., Pipes S.E., Miller J.R., Newman J.D.;
RT   "Pedobacter sp. BMA.";
RL   Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH +
CC         UDP-alpha-D-glucuronate; Xref=Rhea:RHEA:23596,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945, ChEBI:CHEBI:58052, ChEBI:CHEBI:58885;
CC         EC=1.1.1.22; Evidence={ECO:0000256|PIRNR:PIRNR000124};
CC   -!- SIMILARITY: Belongs to the UDP-glucose/GDP-mannose dehydrogenase
CC       family. {ECO:0000256|PIRNR:PIRNR000124}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KLT64002.1}.
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DR   EMBL; LECU01000008; KLT64002.1; -; Genomic_DNA.
DR   RefSeq; WP_047800794.1; NZ_LECU01000008.1.
DR   EnsemblBacteria; KLT64002; KLT64002; AB669_18215.
DR   PATRIC; fig|1663685.3.peg.3810; -.
DR   Proteomes; UP000036014; Unassembled WGS sequence.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0003979; F:UDP-glucose 6-dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:InterPro.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR017476; UDP-Glc/GDP-Man.
DR   InterPro; IPR014027; UDP-Glc/GDP-Man_DH_C.
DR   InterPro; IPR036220; UDP-Glc/GDP-Man_DH_C_sf.
DR   InterPro; IPR014026; UDP-Glc/GDP-Man_DH_dimer.
DR   InterPro; IPR001732; UDP-Glc/GDP-Man_DH_N.
DR   InterPro; IPR028357; UDPglc_DH_bac.
DR   Pfam; PF00984; UDPG_MGDP_dh; 1.
DR   Pfam; PF03720; UDPG_MGDP_dh_C; 1.
DR   Pfam; PF03721; UDPG_MGDP_dh_N; 1.
DR   PIRSF; PIRSF500134; UDPglc_DH_bac; 1.
DR   PIRSF; PIRSF000124; UDPglc_GDPman_dh; 1.
DR   SMART; SM00984; UDPG_MGDP_dh_C; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52413; SSF52413; 1.
DR   TIGRFAMs; TIGR03026; NDP-sugDHase; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000036014};
KW   NAD {ECO:0000256|PIRNR:PIRNR000124, ECO:0000256|PIRSR:PIRSR500134-3};
KW   Oxidoreductase {ECO:0000256|PIRNR:PIRNR000124};
KW   Reference proteome {ECO:0000313|Proteomes:UP000036014}.
FT   DOMAIN      315    417       UDPG_MGDP_dh_C. {ECO:0000259|SMART:
FT                                SM00984}.
FT   ACT_SITE    261    261       Nucleophile. {ECO:0000256|PIRSR:
FT                                PIRSR500134-1}.
FT   BINDING      30     30       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING      35     35       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING      86     86       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     121    121       NAD; via amide nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     153    153       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     264    264       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     329    329       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
SQ   SEQUENCE   436 AA;  48101 MW;  654DC882325A8110 CRC64;
     MKIAVIGTGY VGLVTGTCLA ETGNDVICVD INESKVKKMQ DGEVPIYEPG LDLLFHRNIA
     QGRLTFTTNL ADAVAAAQII FMALPTPPGG DGAADLSFIL GAAKDISKLI TEYKIIVNKS
     TVPVGTADKV KAVFEAHSNI EVDVVSNPEF LREGVAVDDF MKPDRVVLGT RSEKAKKLMT
     ELYGPYVRQG NPILFMDERS SELTKYAANS FLATKITFMN EVANLCELVG ADVDAVRKGI
     GSDERIGKRF LFPGVGYGGS CFPKDVQALV KSSDDYEYDF QILKSVMEVN ERQKTILVDK
     VLKYYKGNVQ GKHFALWGLA FKPETDDIRE APALYIIDAL VKNGATVTVF DPEAMENVQA
     VIGDKVNYSQ SQYDALEGAD ALLIATEWSV FRNPDFEKID QILKNKVIFD GRNLYDLQKM
     IDLGYYYNSI GRKLID
//
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