ID A0A0J1CKZ7_9BURK Unreviewed; 278 AA.
AC A0A0J1CKZ7;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=2,5-didehydrogluconate reductase {ECO:0000313|EMBL:KLU21397.1};
GN ORFNames=EOS_36125 {ECO:0000313|EMBL:KLU21397.1};
OS Caballeronia mineralivorans PML1(12).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Caballeronia.
OX NCBI_TaxID=908627 {ECO:0000313|EMBL:KLU21397.1, ECO:0000313|Proteomes:UP000035963};
RN [1] {ECO:0000313|EMBL:KLU21397.1, ECO:0000313|Proteomes:UP000035963}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PML1(12) {ECO:0000313|Proteomes:UP000035963};
RX PubMed=26205858;
RA Uroz S., Oger P.;
RT "Draft Genome Sequence of Burkholderia sp. Strain PML1(12), an
RT Ectomycorrhizosphere-Inhabiting Bacterium with Effective Mineral-Weathering
RT Ability.";
RL Genome Announc. 3:e00798-15(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KLU21397.1}.
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DR EMBL; AEJF01000221; KLU21397.1; -; Genomic_DNA.
DR RefSeq; WP_047897019.1; NZ_AEJF01000221.1.
DR AlphaFoldDB; A0A0J1CKZ7; -.
DR PATRIC; fig|908627.4.peg.8082; -.
DR OrthoDB; 9804790at2; -.
DR Proteomes; UP000035963; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt.
DR GO; GO:0044281; P:small molecule metabolic process; IEA:UniProt.
DR Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR InterPro; IPR020471; AKR.
DR InterPro; IPR018170; Aldo/ket_reductase_CS.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR43827; 2,5-DIKETO-D-GLUCONIC ACID REDUCTASE; 1.
DR PANTHER; PTHR43827:SF3; ALDO-KETO REDUCTASE; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR PIRSF; PIRSF000097; AKR; 1.
DR PRINTS; PR00069; ALDKETRDTASE.
DR SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
DR PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
PE 4: Predicted;
FT DOMAIN 14..256
FT /note="NADP-dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00248"
FT ACT_SITE 47
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT BINDING 105
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT SITE 72
FT /note="Lowers pKa of active site Tyr"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ SEQUENCE 278 AA; 30291 MW; A322C9EEECC83567 CRC64;
MQNVNVGSAA IPAIGFGTYG MSGADVYRLI PAALRAGFRH VDTAQIYGNE GEIGDCVAAS
GIPRSEIFLT TKVWVSNYSE RFFEASVNES LRKLKTDYID LLLLHWPQSD VSLAEQIAGL
NAVARAGKVR HIGVSNFNRA LMTESIRLSA VPLVTNQFEY HPYLNQSLLI ESTLQAGLAV
TGYCGMAIGR VFSDPTLKEI AARHDKTIAQ IVLRWLVQQR GIVALSRTTR IDRLAQNLAV
FDFELDGADM AAIHALATTD SRIVDPPGLA PLWDSMSA
//
