ID A0A0J1ETV4_9MICC Unreviewed; 1240 AA.
AC A0A0J1ETV4;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE RecName: Full=Transcription-repair-coupling factor {ECO:0000256|HAMAP-Rule:MF_00969};
DE Short=TRCF {ECO:0000256|HAMAP-Rule:MF_00969};
DE EC=3.6.4.- {ECO:0000256|HAMAP-Rule:MF_00969};
GN Name=mfd {ECO:0000256|HAMAP-Rule:MF_00969};
GN ORFNames=ABL57_15330 {ECO:0000313|EMBL:KLU08884.1};
OS Kocuria sp. SM24M-10.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC Kocuria.
OX NCBI_TaxID=1660349 {ECO:0000313|EMBL:KLU08884.1, ECO:0000313|Proteomes:UP000036489};
RN [1] {ECO:0000313|EMBL:KLU08884.1, ECO:0000313|Proteomes:UP000036489}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SM24M-10 {ECO:0000313|EMBL:KLU08884.1,
RC ECO:0000313|Proteomes:UP000036489};
RA Palermo B.R., Castro D.B., Cauz A.C., Magalhaes B.L., Carlos C.,
RA Costa F.L., Scagion G.P., Higac J.H., Pereira L.B., Almeida L.D.,
RA Neves M.S., Cordeiro M.A., Prado P.F., Silva T.M., Balsalobre T.W.,
RA Paulino L.C., Vicentini R., Ferraz L.F., Ottoboni L.M.;
RT "Draft genome sequence of Kocuria sp. SM24M-10 isolated from coral mucus.";
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Couples transcription and DNA repair by recognizing RNA
CC polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent
CC release of RNAP and its truncated transcript from the DNA, and
CC recruitment of nucleotide excision repair machinery to the damaged
CC site. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the helicase family.
CC RecG subfamily. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the UvrB family.
CC {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KLU08884.1}.
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DR EMBL; LDNX01000129; KLU08884.1; -; Genomic_DNA.
DR RefSeq; WP_047804345.1; NZ_LDNX01000129.1.
DR AlphaFoldDB; A0A0J1ETV4; -.
DR PATRIC; fig|1660349.3.peg.1088; -.
DR OrthoDB; 9804325at2; -.
DR Proteomes; UP000036489; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0000716; P:transcription-coupled nucleotide-excision repair, DNA damage recognition; IEA:UniProtKB-UniRule.
DR CDD; cd17991; DEXHc_TRCF; 1.
DR Gene3D; 2.40.10.170; -; 1.
DR Gene3D; 3.40.50.11180; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.2060.10; Penicillin-binding protein 1b domain; 1.
DR Gene3D; 3.90.1150.50; Transcription-repair-coupling factor, D7 domain; 1.
DR HAMAP; MF_00969; TRCF; 1.
DR InterPro; IPR003711; CarD-like/TRCF_RID.
DR InterPro; IPR036101; CarD-like/TRCF_RID_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR004576; Mfd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047112; RecG/Mfd.
DR InterPro; IPR037235; TRCF-like_C_D7.
DR InterPro; IPR005118; TRCF_C.
DR InterPro; IPR041471; UvrB_inter.
DR NCBIfam; TIGR00580; mfd; 1.
DR PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR Pfam; PF02559; CarD_TRCF_RID; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF03461; TRCF; 1.
DR Pfam; PF17757; UvrB_inter; 1.
DR SMART; SM01058; CarD_TRCF; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00982; TRCF; 1.
DR SUPFAM; SSF141259; CarD-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF143517; TRCF domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00969};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00969}.
FT DOMAIN 701..862
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 887..1037
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1240 AA; 134365 MW; E5013E3B905D7E48 CRC64;
MTLSGLLAAL GAERSFANLR TQVAFPPGER SPETVISAPD GMRPVITAQL RGALDDASGG
AADGRAPVLL AVTATGRESE DLAAALGAYL PTAGIAEFPA WETLPHERLS PRSDTVGRRL
DVLRRLAGHD PERPLQVLTA PVRSVLQPVV EGLGEMTPVR FARGEELDFD AAVTALAQAA
YARVDMVTRR GEFAVRGGII DVFSPVEDHP VRIEFFGDEV DELRWFAVAD QRTLTGTDHP
DRLVAPPCRE VLITPSVMSR AAALRNALPG AESMLERIAG GIYVEGMESL APLLVDGMVP
MLSLLPPGSL VVVMEPEKVR ARAHDLVATN EEFLLAAWDS ASDGLSAPID IGSAEHALPT
GDDGGRTLSS GSFQTLAEAR STALGAGLGW WAVTALNVNA VAGQDVDADT AAEDIALLDS
DADTLTVAAR DPLGFHGDVE AMLEFLSGRV ADGWRVVAVT EGPGPLARIA ELLHDAGIPA
ARRESLEEPP QPGVVELTTA VAGKGFALDG PRIVLLTEAD LLGKASPYTT KDMRKLPVRR
KRNAVDPLAL SPGDFVVHEQ HGVGQFVELI QRPIAGAMTK PGQPKPVREY LVLEYAASKR
NGPKDRLFVP TDQLDQVTNY VGGETPSLSK MGGADWNKTK RAAKKAVKDI ANELIRLYSA
RMASRGHAFG EDTPWQRELE EAFPYIETPD QLTTIDEVKA DMQREVPMDR LISGDVGYGK
TEVAVRAAFK AVQDGKQVAV LVPTTLLAQQ HAETFTERFS GFPVHLAALS RFQTAKETKE
TLAGLKDGSI DVVIGTHRLL SKEVQFKDLG LVVIDEEQRF GVEHKEKLKA MRTNVDVLAM
SATPIPRTLE MSLTGIRETS TLATPPEERH PVLTYVGAYT DKQVSAAVRR ELMREGQVFY
IHNRVSSIER KAKEIAELVP EARIAVAHGQ MSESRLEQII VDFWEKKFDV LVCTTIVETG
LDIANANTLI VDGADRYGLS QLHQLRGRVG RGRERAYAYF LYQAEKPLSE TALERLKAVA
AHNELGAGMQ LAVKDLEIRG AGNLLGGEQS GHIAGVGFDM YLRLVGEAVA EYRGEEDERP
TEMKIELPVN AYLPHEYVPG EPLRLEAYRN LANAATEEAI QEVADELVDR YGEVPEPVQN
LLEVARFRVT ARAAGLTDVA AQGNMVRFAP AELPESRQMR LTRLYPGAQV KTVPGTDTAQ
VLIPKPKTAR IGGKDLVDRE ILEWARGVVE AVFAREPATA
//
