ID A0A0J1EXM2_9MICC Unreviewed; 650 AA.
AC A0A0J1EXM2;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Propionyl-CoA synthetase {ECO:0000313|EMBL:KLU10169.1};
DE EC=6.2.1.17 {ECO:0000313|EMBL:KLU10169.1};
GN Name=prpE {ECO:0000313|EMBL:KLU10169.1};
GN ORFNames=ABL57_08170 {ECO:0000313|EMBL:KLU10169.1};
OS Kocuria sp. SM24M-10.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC Kocuria.
OX NCBI_TaxID=1660349 {ECO:0000313|EMBL:KLU10169.1, ECO:0000313|Proteomes:UP000036489};
RN [1] {ECO:0000313|EMBL:KLU10169.1, ECO:0000313|Proteomes:UP000036489}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SM24M-10 {ECO:0000313|EMBL:KLU10169.1,
RC ECO:0000313|Proteomes:UP000036489};
RA Palermo B.R., Castro D.B., Cauz A.C., Magalhaes B.L., Carlos C.,
RA Costa F.L., Scagion G.P., Higac J.H., Pereira L.B., Almeida L.D.,
RA Neves M.S., Cordeiro M.A., Prado P.F., Silva T.M., Balsalobre T.W.,
RA Paulino L.C., Vicentini R., Ferraz L.F., Ottoboni L.M.;
RT "Draft genome sequence of Kocuria sp. SM24M-10 isolated from coral mucus.";
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KLU10169.1}.
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DR EMBL; LDNX01000067; KLU10169.1; -; Genomic_DNA.
DR RefSeq; WP_047802971.1; NZ_LDNX01000067.1.
DR AlphaFoldDB; A0A0J1EXM2; -.
DR PATRIC; fig|1660349.3.peg.3727; -.
DR OrthoDB; 9803968at2; -.
DR Proteomes; UP000036489; Unassembled WGS sequence.
DR GO; GO:0050218; F:propionate-CoA ligase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43347; ACYL-COA SYNTHETASE; 1.
DR PANTHER; PTHR43347:SF3; ACYL-COA SYNTHETASE SHORT-CHAIN FAMILY MEMBER 3, MITOCHONDRIAL; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW Ligase {ECO:0000313|EMBL:KLU10169.1}.
FT DOMAIN 13..67
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 74..466
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 532..610
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 650 AA; 70606 MW; FDD37E4559AB580A CRC64;
MSTEQQTTQA EDYAEVYRRS VRDPERFWLE AARAVDWTRE PTVALDAAMA PLYRWFPDGE
LNTSYNALDR HVEAGHGERT ALVYDSALLG VQERYSYARL RDEVALFAGA LAARGVGRGD
RVLVYLPMIP QAAVAMLACA RLGAVHSVVF GGFAPKELAA RIDDSRPRVV VTTTGGLEPR
RRIEYIPAIE EALRLARHEP GTVVVHERPG FETTVEQARE RAGHGEQPAV EWLGWDAAVE
GAEPAAPVPV AATDPLYVLY TSGTTGAPKG VVRDNGGHAV AMTWSMRHIY DVGPGEVMWT
ASDVGWVVGH SYIVYGPLLA GATTVLYEGK PVGTPDAGAF WRRVEDHGVK VLFTAPTALR
AIRRADPEGE LVRRHDIGSL QALFVAGERL DPETYGWASR VLGVPVVDHW WQTETGWAIC
ANPFGIERLP LKPGSPSVPV PGYRVEVLDP LGQPVATGEE GNIALRLPLP PGTLTTLWGD
DRRFVDSYLT AFPGYYATGD SGHVDEDGYV YVMGRTDDVI NVSGHRLSTG AMEQVLASHP
AVAECAVIGV ADPLKGQRPA GYVVLKSGVE VPEERLRDEL VALVRRQIGA VADFKDVAVV
EGLPKTRSGK ILRKTMRQIA DGEDYTVPST IEDSTVLEAL EGVLRPPRAG
//
