ID A0A0J1IBY4_9FIRM Unreviewed; 254 AA.
AC A0A0J1IBY4;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Methionine synthase {ECO:0000313|EMBL:KLU62186.1};
DE EC=2.1.1.13 {ECO:0000313|EMBL:KLU62186.1};
GN Name=metH_15 {ECO:0000313|EMBL:KLU62186.1};
GN ORFNames=CEB3_c14050 {ECO:0000313|EMBL:KLU62186.1};
OS Peptococcaceae bacterium CEB3.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Peptococcaceae.
OX NCBI_TaxID=999898 {ECO:0000313|EMBL:KLU62186.1, ECO:0000313|Proteomes:UP000035957};
RN [1] {ECO:0000313|EMBL:KLU62186.1, ECO:0000313|Proteomes:UP000035957}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CEB3 {ECO:0000313|EMBL:KLU62186.1,
RC ECO:0000313|Proteomes:UP000035957};
RA Poehlein A., Petzsch P., Johnson B.D., Schloemann M., Daniel R.,
RA Muehling M.;
RT "Genome sequence of the moderately acidophilic sulfate reducing
RT Peptococcaceae bacterium strain CEB3.";
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KLU62186.1}.
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DR EMBL; LDXJ01000047; KLU62186.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0J1IBY4; -.
DR STRING; 999898.CEB3_c14050; -.
DR PATRIC; fig|999898.3.peg.1600; -.
DR Proteomes; UP000035957; Unassembled WGS sequence.
DR GO; GO:0031419; F:cobalamin binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008705; F:methionine synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR Gene3D; 1.10.1240.10; Methionine synthase domain; 1.
DR InterPro; IPR003759; Cbl-bd_cap.
DR InterPro; IPR006158; Cobalamin-bd.
DR InterPro; IPR036724; Cobalamin-bd_sf.
DR InterPro; IPR036594; Meth_synthase_dom.
DR PANTHER; PTHR45833:SF2; BIFUNCTIONAL HOMOCYSTEINE S-METHYLTRANSFERASE_5,10-METHYLENETETRAHYDROFOLATE REDUCTASE; 1.
DR PANTHER; PTHR45833; METHIONINE SYNTHASE; 1.
DR Pfam; PF02310; B12-binding; 1.
DR Pfam; PF02607; B12-binding_2; 1.
DR SMART; SM01018; B12-binding_2; 1.
DR SUPFAM; SSF52242; Cobalamin (vitamin B12)-binding domain; 1.
DR SUPFAM; SSF47644; Methionine synthase domain; 1.
DR PROSITE; PS51332; B12_BINDING; 1.
DR PROSITE; PS51337; B12_BINDING_NTER; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000313|EMBL:KLU62186.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000035957};
KW Transferase {ECO:0000313|EMBL:KLU62186.1}.
FT DOMAIN 27..120
FT /note="B12-binding N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51337"
FT DOMAIN 119..246
FT /note="B12-binding"
FT /evidence="ECO:0000259|PROSITE:PS51332"
SQ SEQUENCE 254 AA; 27843 MW; 792D6DD995AE83C7 CRC64;
MRPYPESSKV FIRYDLNTLH RDFTPTKSDA KLPRSTLQDV INTVVAGECE NISEVVNEAL
KQYPPLEVIE QGLINGMEKV GHLWEERIYY LPQTLAASDT MQIGLEICEA KMGHSGWKKA
VVVTHTAEGD LHDLGQKIVN ALLSASGFQV IDLGKDVPVE EVVAAVEKYH PVMLTGTAGL
TLTMNAFERI SHELSYRGLE LPFVCGGGGG VTADFVNSFQ YGIYGTDAAQ APPMAVDALT
GKSWLEIRKK YNGI
//
