ID A0A0J5FSF5_9GAMM Unreviewed; 1160 AA.
AC A0A0J5FSF5;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE RecName: Full=DNA polymerase III subunit alpha {ECO:0000256|ARBA:ARBA00019114};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN Name=dnaE {ECO:0000313|EMBL:KMJ45211.1};
GN ORFNames=AB204_10080 {ECO:0000313|EMBL:KMJ45211.1};
OS Xenorhabdus khoisanae.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Morganellaceae; Xenorhabdus.
OX NCBI_TaxID=880157 {ECO:0000313|EMBL:KMJ45211.1, ECO:0000313|Proteomes:UP000036277};
RN [1] {ECO:0000313|EMBL:KMJ45211.1, ECO:0000313|Proteomes:UP000036277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MCB {ECO:0000313|EMBL:KMJ45211.1,
RC ECO:0000313|Proteomes:UP000036277};
RA Naidoo S., Featherston J., Gray V.M.;
RT "Draft Whole-Genome Sequence of the Entomopathogenic Bacterium Xenorhabdus
RT khoisanae.";
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KMJ45211.1}.
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DR EMBL; LFCV01000061; KMJ45211.1; -; Genomic_DNA.
DR RefSeq; WP_047963246.1; NZ_LFCV01000061.1.
DR AlphaFoldDB; A0A0J5FSF5; -.
DR STRING; 880157.AB204_10080; -.
DR PATRIC; fig|880157.4.peg.2136; -.
DR OrthoDB; 9803237at2; -.
DR Proteomes; UP000036277; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd04485; DnaE_OBF; 1.
DR CDD; cd07433; PHP_PolIIIA_DnaE1; 1.
DR Gene3D; 1.10.150.870; -; 1.
DR Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR048472; DNA_pol_IIIA_C.
DR InterPro; IPR004805; DnaE2/DnaE/PolC.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR004365; NA-bd_OB_tRNA.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR NCBIfam; TIGR00594; polc; 1.
DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR PANTHER; PTHR32294:SF0; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF20914; DNA_pol_IIIA_C; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF02811; PHP; 1.
DR Pfam; PF01336; tRNA_anti-codon; 1.
DR SMART; SM00481; POLIIIAc; 1.
DR SUPFAM; SSF89550; PHP domain-like; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000313|EMBL:KMJ45211.1};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:KMJ45211.1}.
FT DOMAIN 7..74
FT /note="Polymerase/histidinol phosphatase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00481"
SQ SEQUENCE 1160 AA; 130332 MW; 4341EC33B39AB49F CRC64;
MTEPRFVHLR VHSDYSMIDG LAKTGSLVKK VAKLGMPALA ITDFTNLCGL VKFYGSAHDA
GIKPIIGADF YVESELLGDE YAHLTILARN NEGYQNLTLL ISEAYQKGYG AIGPTIKREW
LVARKAGLIL LSGGRMGDVG KFLLRGNRAM VDLCLDFYQE HFPDSYYLEL IRTGRQDEEN
YLHAVVELAA EKNVPVVATN DVCFLESTDF DAHEIRVAIH DGYTLVDPKR PKNYSPQQYL
RSEQEMCELF SDIPEALQNS VEIAKRCNVT IRLGEYFLPQ FPTGDMSTED FLIKKSKQGL
EERLEFLYPD PEIRAQKRLG YDDRLDIELK VINQMGFPGY FLIVMEFIQW SKDNGVPVGP
GRGSGAGSLV AYALKITDLD PLEFDLLFER FLNPERVSMP DFDVDFCMEK RDQVIDHVAD
MYGRDAVSQI ITFGTMAAKA VIRDVGRVLG HPYGFVDRIS KLVPPDPGMT LEKAFVAEPQ
LPEIYEADEE VKALIDMARK LEGVTRNAGK HAGGVVIAPT KITDFAPIYC DPEGQNPVTQ
FDKNDVEYAG LVKFDFLGLR TLTIINWALD MVNARRAKKG LELIDIAAIP LDDQKSFDML
QRSETTAVFQ LESRGMKDLI KRLRPDCFED MIALVALFRP GPLQSGMVDN FIDRKHGREE
ISYPDVEWQH ETLKPVLEPT YGIILYQEQV MQIAQVLAGY TLGGADMLRR AMGKKKPEEM
AKQRSVFEEG AIKQGVDGEL SMKIFDLVEK FAGYGFNKSH SAAYALVSYQ TLWLKAHYPA
EFMAAVMTAD MDNTEKVVGL VDECWRMGLK VLPPDINSGL YHFHVNDEGE IVYGIGAIKG
VGEGPIEAIL EARQKGGHFK ELFDLCARVD IKKLNRRVME KLIMSGAFDR LGPHRAALMS
SLEDALKAAD QHAKAEAIGQ TDMFGVLAEE PEEVERSYAS TPKWPDQVVL DGERETLGLY
LTGHPITSYL KEIERYTNGL RLKDVNPTPR GQVTTVVGLV LASKIVTTKR GNRIGISTLD
DRSGRLEIML FSDALERYQH LLEQDKILIA TGQVSFDDFS GGLKMTVREL MDISEAREKF
ARGLAISLSD RQIDEQLLNR LRGVLEPHRS GTIPVHLYYQ RVDARARLRF GATWRVTPTD
TLLTDLRTLL GNEQVELEFD
//