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Database: UniProt
Entry: A0A0J5FSF5_9GAMM
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ID   A0A0J5FSF5_9GAMM        Unreviewed;      1160 AA.
AC   A0A0J5FSF5;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   24-JAN-2024, entry version 31.
DE   RecName: Full=DNA polymerase III subunit alpha {ECO:0000256|ARBA:ARBA00019114};
DE            EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN   Name=dnaE {ECO:0000313|EMBL:KMJ45211.1};
GN   ORFNames=AB204_10080 {ECO:0000313|EMBL:KMJ45211.1};
OS   Xenorhabdus khoisanae.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Xenorhabdus.
OX   NCBI_TaxID=880157 {ECO:0000313|EMBL:KMJ45211.1, ECO:0000313|Proteomes:UP000036277};
RN   [1] {ECO:0000313|EMBL:KMJ45211.1, ECO:0000313|Proteomes:UP000036277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MCB {ECO:0000313|EMBL:KMJ45211.1,
RC   ECO:0000313|Proteomes:UP000036277};
RA   Naidoo S., Featherston J., Gray V.M.;
RT   "Draft Whole-Genome Sequence of the Entomopathogenic Bacterium Xenorhabdus
RT   khoisanae.";
RL   Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00024632};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KMJ45211.1}.
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DR   EMBL; LFCV01000061; KMJ45211.1; -; Genomic_DNA.
DR   RefSeq; WP_047963246.1; NZ_LFCV01000061.1.
DR   AlphaFoldDB; A0A0J5FSF5; -.
DR   STRING; 880157.AB204_10080; -.
DR   PATRIC; fig|880157.4.peg.2136; -.
DR   OrthoDB; 9803237at2; -.
DR   Proteomes; UP000036277; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd04485; DnaE_OBF; 1.
DR   CDD; cd07433; PHP_PolIIIA_DnaE1; 1.
DR   Gene3D; 1.10.150.870; -; 1.
DR   Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR   InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR   InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR   InterPro; IPR040982; DNA_pol3_finger.
DR   InterPro; IPR048472; DNA_pol_IIIA_C.
DR   InterPro; IPR004805; DnaE2/DnaE/PolC.
DR   InterPro; IPR029460; DNAPol_HHH.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR004365; NA-bd_OB_tRNA.
DR   InterPro; IPR004013; PHP_dom.
DR   InterPro; IPR003141; Pol/His_phosphatase_N.
DR   InterPro; IPR016195; Pol/histidinol_Pase-like.
DR   NCBIfam; TIGR00594; polc; 1.
DR   PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR   PANTHER; PTHR32294:SF0; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR   Pfam; PF07733; DNA_pol3_alpha; 1.
DR   Pfam; PF17657; DNA_pol3_finger; 1.
DR   Pfam; PF20914; DNA_pol_IIIA_C; 1.
DR   Pfam; PF14579; HHH_6; 1.
DR   Pfam; PF02811; PHP; 1.
DR   Pfam; PF01336; tRNA_anti-codon; 1.
DR   SMART; SM00481; POLIIIAc; 1.
DR   SUPFAM; SSF89550; PHP domain-like; 1.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW   ECO:0000313|EMBL:KMJ45211.1};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:KMJ45211.1}.
FT   DOMAIN          7..74
FT                   /note="Polymerase/histidinol phosphatase N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00481"
SQ   SEQUENCE   1160 AA;  130332 MW;  4341EC33B39AB49F CRC64;
     MTEPRFVHLR VHSDYSMIDG LAKTGSLVKK VAKLGMPALA ITDFTNLCGL VKFYGSAHDA
     GIKPIIGADF YVESELLGDE YAHLTILARN NEGYQNLTLL ISEAYQKGYG AIGPTIKREW
     LVARKAGLIL LSGGRMGDVG KFLLRGNRAM VDLCLDFYQE HFPDSYYLEL IRTGRQDEEN
     YLHAVVELAA EKNVPVVATN DVCFLESTDF DAHEIRVAIH DGYTLVDPKR PKNYSPQQYL
     RSEQEMCELF SDIPEALQNS VEIAKRCNVT IRLGEYFLPQ FPTGDMSTED FLIKKSKQGL
     EERLEFLYPD PEIRAQKRLG YDDRLDIELK VINQMGFPGY FLIVMEFIQW SKDNGVPVGP
     GRGSGAGSLV AYALKITDLD PLEFDLLFER FLNPERVSMP DFDVDFCMEK RDQVIDHVAD
     MYGRDAVSQI ITFGTMAAKA VIRDVGRVLG HPYGFVDRIS KLVPPDPGMT LEKAFVAEPQ
     LPEIYEADEE VKALIDMARK LEGVTRNAGK HAGGVVIAPT KITDFAPIYC DPEGQNPVTQ
     FDKNDVEYAG LVKFDFLGLR TLTIINWALD MVNARRAKKG LELIDIAAIP LDDQKSFDML
     QRSETTAVFQ LESRGMKDLI KRLRPDCFED MIALVALFRP GPLQSGMVDN FIDRKHGREE
     ISYPDVEWQH ETLKPVLEPT YGIILYQEQV MQIAQVLAGY TLGGADMLRR AMGKKKPEEM
     AKQRSVFEEG AIKQGVDGEL SMKIFDLVEK FAGYGFNKSH SAAYALVSYQ TLWLKAHYPA
     EFMAAVMTAD MDNTEKVVGL VDECWRMGLK VLPPDINSGL YHFHVNDEGE IVYGIGAIKG
     VGEGPIEAIL EARQKGGHFK ELFDLCARVD IKKLNRRVME KLIMSGAFDR LGPHRAALMS
     SLEDALKAAD QHAKAEAIGQ TDMFGVLAEE PEEVERSYAS TPKWPDQVVL DGERETLGLY
     LTGHPITSYL KEIERYTNGL RLKDVNPTPR GQVTTVVGLV LASKIVTTKR GNRIGISTLD
     DRSGRLEIML FSDALERYQH LLEQDKILIA TGQVSFDDFS GGLKMTVREL MDISEAREKF
     ARGLAISLSD RQIDEQLLNR LRGVLEPHRS GTIPVHLYYQ RVDARARLRF GATWRVTPTD
     TLLTDLRTLL GNEQVELEFD
//
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