ID A0A0J5GE45_9NEIS Unreviewed; 720 AA.
AC A0A0J5GE45;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase {ECO:0000313|EMBL:KMJ52557.1};
GN ORFNames=ACG97_12925 {ECO:0000313|EMBL:KMJ52557.1};
OS Vogesella sp. EB.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales;
OC Chromobacteriaceae; Vogesella.
OX NCBI_TaxID=1526735 {ECO:0000313|EMBL:KMJ52557.1, ECO:0000313|Proteomes:UP000054352};
RN [1] {ECO:0000313|EMBL:KMJ52557.1, ECO:0000313|Proteomes:UP000054352}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EB {ECO:0000313|EMBL:KMJ52557.1,
RC ECO:0000313|Proteomes:UP000054352};
RA Arrua Day P., Revale S., Alvarez H.M.;
RT "Genome wide analysis of metabolism in the polyhydroxybutyrate-producing
RT Vogesella sp. strain EB.";
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate)
CC is a mediator of the stringent response that coordinates a variety of
CC cellular activities in response to changes in nutritional abundance.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- SIMILARITY: Belongs to the relA/spoT family.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KMJ52557.1}.
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DR EMBL; LFDT01000024; KMJ52557.1; -; Genomic_DNA.
DR RefSeq; WP_047967783.1; NZ_LFDT01000024.1.
DR AlphaFoldDB; A0A0J5GE45; -.
DR STRING; 1526735.ACG97_12925; -.
DR PATRIC; fig|1526735.3.peg.2770; -.
DR OrthoDB; 9805041at2; -.
DR Proteomes; UP000054352; Unassembled WGS sequence.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR CDD; cd00077; HDc; 1.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR CDD; cd01668; TGS_RSH; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR004811; RelA/Spo_fam.
DR InterPro; IPR007685; RelA_SpoT.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR InterPro; IPR033655; TGS_RelA/SpoT.
DR NCBIfam; TIGR00691; spoT_relA; 1.
DR PANTHER; PTHR21262:SF31; BIFUNCTIONAL (P)PPGPP SYNTHASE_HYDROLASE SPOT; 1.
DR PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR Pfam; PF13291; ACT_4; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF04607; RelA_SpoT; 1.
DR Pfam; PF02824; TGS; 1.
DR SMART; SM00471; HDc; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81271; TGS-like; 1.
DR PROSITE; PS51671; ACT; 1.
DR PROSITE; PS51831; HD; 1.
DR PROSITE; PS51880; TGS; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:KMJ52557.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054352}.
FT DOMAIN 61..160
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
FT DOMAIN 402..463
FT /note="TGS"
FT /evidence="ECO:0000259|PROSITE:PS51880"
FT DOMAIN 645..720
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
SQ SEQUENCE 720 AA; 79972 MW; 4074FA66E934CC6C CRC64;
MSQDSAAEHI DYNALVDAEA AALFDAANQY LRPEDVQLLR QAFATAREAH EGQTRKSGEP
YITHPLAVAA MLTDWRLDAQ GLAAALMHDV LEDTGVSKPT LSEKFGRTIA DLVDGLSKLE
RLEYQTKESA QAENFRKMVL AMARDIRVII VKLADRLHNM RTLDAMREDK RQRIALETLE
IYAPIANRIG LNKVYRELQD LAFKHLHPHR YSVLSKAVRA ARGNRREVVN KILQAVTQKL
GEANIEATIK GREKNLYSIY KKMQEKHLSF SEVLDIYGFR IVVKDNASCY LTLGALHSLY
KPIPGKFKDY IAIPKGNGYQ SLHTTLFGPY GTPVEMQIRT QEMNAVAEAG VASHWMYKSG
DASIDAAKQR THQWLQSILD MQEESEDAIE FLEHIKIDLF PDEVYVFTPK GKIMVLPQGS
TPVDFAYAVH TDIGHRCIAG RVNFNLVPLR TVLRNGDTVE IITSTQAKPN PSWLNFVQSG
RARSGIRNYL KTLQQKDAVQ LGEKLLRQAA SALSPTPLDI SPKLEDSLLH ALGERQRSFN
DLLADIGTGK QLAIVIARKL FELSGEQLGQ TPDVGPVTIR GNEGGAVQLS SCCNPIPGDA
IIGAISKGQG LLVHRKGCGN AARIDPEKLL EVNWEPQKDR MFGVNISVLA HNQRGALAEI
AAAISQASAN IETVDTQENH GGDGFIHIHF RLQVDNLIHL ENVLTAIQQV NVVQQAERRQ
//
