ID A0A0J5GXJ3_9BACI Unreviewed; 396 AA.
AC A0A0J5GXJ3;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Malate dehydrogenase {ECO:0000313|EMBL:KMJ58748.1};
GN ORFNames=AB685_06595 {ECO:0000313|EMBL:KMJ58748.1};
OS Bacillus sp. LL01.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=1665556 {ECO:0000313|EMBL:KMJ58748.1, ECO:0000313|Proteomes:UP000036436};
RN [1] {ECO:0000313|EMBL:KMJ58748.1, ECO:0000313|Proteomes:UP000036436}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LL01 {ECO:0000313|EMBL:KMJ58748.1,
RC ECO:0000313|Proteomes:UP000036436};
RA Vilo C., Galetovic A., Araya J., Gomez Silva B., Dong Q.;
RT "Draft Genome Sequence of a Bacillus Bacterium from the Atacama Desert
RT Wetlands Metagenome.";
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|PIRSR:PIRSR000106-3};
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|PIRSR:PIRSR000106-3};
CC Note=Divalent metal cations. Prefers magnesium or manganese.
CC {ECO:0000256|PIRSR:PIRSR000106-3};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SIMILARITY: Belongs to the malic enzymes family.
CC {ECO:0000256|ARBA:ARBA00008785}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KMJ58748.1}.
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DR EMBL; LFEL01000002; KMJ58748.1; -; Genomic_DNA.
DR RefSeq; WP_047969805.1; NZ_LFEL01000002.1.
DR AlphaFoldDB; A0A0J5GXJ3; -.
DR PATRIC; fig|1665556.3.peg.2275; -.
DR OrthoDB; 9805787at2; -.
DR Proteomes; UP000036436; Unassembled WGS sequence.
DR GO; GO:0004471; F:malate dehydrogenase (decarboxylating) (NAD+) activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0008948; F:oxaloacetate decarboxylase activity; IEA:UniProtKB-EC.
DR CDD; cd05311; NAD_bind_2_malic_enz; 1.
DR Gene3D; 3.40.50.10380; Malic enzyme, N-terminal domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR InterPro; IPR015884; Malic_enzyme_CS.
DR InterPro; IPR012301; Malic_N_dom.
DR InterPro; IPR037062; Malic_N_dom_sf.
DR InterPro; IPR012302; Malic_NAD-bd.
DR InterPro; IPR045213; Malic_NAD-bd_bact_type.
DR InterPro; IPR001891; Malic_OxRdtase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43237; NADP-DEPENDENT MALIC ENZYME; 1.
DR PANTHER; PTHR43237:SF4; NADP-DEPENDENT MALIC ENZYME; 1.
DR Pfam; PF00390; malic; 1.
DR Pfam; PF03949; Malic_M; 1.
DR PIRSF; PIRSF000106; ME; 1.
DR SMART; SM01274; malic; 1.
DR SMART; SM00919; Malic_M; 1.
DR SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00331; MALIC_ENZYMES; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR000106-3}.
FT DOMAIN 18..151
FT /note="Malic enzyme N-terminal"
FT /evidence="ECO:0000259|SMART:SM01274"
FT DOMAIN 163..386
FT /note="Malic enzyme NAD-binding"
FT /evidence="ECO:0000259|SMART:SM00919"
FT ACT_SITE 39
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000106-1"
FT ACT_SITE 94
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000106-1"
FT BINDING 136
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /evidence="ECO:0000256|PIRSR:PIRSR000106-3"
FT BINDING 137
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /evidence="ECO:0000256|PIRSR:PIRSR000106-3"
FT BINDING 162
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /evidence="ECO:0000256|PIRSR:PIRSR000106-3"
FT BINDING 288
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000106-2"
FT BINDING 318
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000106-2"
SQ SEQUENCE 396 AA; 41920 MW; 3D56F3F55FDD7D28 CRC64;
MKGTNLKEKA LNLHREHAGK IAVVSKIDIH TEDDLSLAYT PGVGDVCKEI AKDPSKINSL
TSRGNMVAVV TDGTAVLGLG DIGPKAAMPV MEGKSILFKQ FADIDAFPIC LDTKDVDEIV
SIVKALQPTF AGINLEDIAA PRCFEIEERL KKELDIPVFH DDQHGTAIVV LGGLINALKL
VKKPMETTKI VINGAGAAGI SIAKLLLTAG FADITLVSLE GIVCEGLDWL NDSQADISKR
TNLHQINGTL NEAISGADVF IGVSGPAALN QSHIMKMAKD PVVFALANPI PEIYPEEALA
AGAAVVGTGR SDYPNQINNL LAFPGIFRGA IDSGATNITE EMKIAAAYAI AKMIPEKELR
ADNIIPRALD KQVAVEVSMA VANIANKKSD RSSSVS
//