ID   A0A0J5KYB8_PLUGE        Unreviewed;       759 AA.
AC   A0A0J5KYB8;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=Malic enzyme {ECO:0000313|EMBL:KMK11089.1};
DE            EC=1.1.1.40 {ECO:0000313|EMBL:KMK11089.1};
GN   ORFNames=ABW06_22995 {ECO:0000313|EMBL:KMK11089.1};
OS   Pluralibacter gergoviae (Enterobacter gergoviae).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Pluralibacter.
OX   NCBI_TaxID=61647 {ECO:0000313|EMBL:KMK11089.1, ECO:0000313|Proteomes:UP000036196};
RN   [1] {ECO:0000313|EMBL:KMK11089.1, ECO:0000313|Proteomes:UP000036196}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JS81F13 {ECO:0000313|EMBL:KMK11089.1,
RC   ECO:0000313|Proteomes:UP000036196};
RA   Greninger A.L., Miller S.;
RT   "Genome sequences of Pluralibacter gergoviae.";
RL   Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|ARBA:ARBA00001936};
CC   -!- SIMILARITY: In the N-terminal section; belongs to the malic enzymes
CC       family. {ECO:0000256|ARBA:ARBA00007686}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KMK11089.1}.
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DR   EMBL; LDZF01000034; KMK11089.1; -; Genomic_DNA.
DR   RefSeq; WP_048274630.1; NZ_VWRP01000074.1.
DR   STRING; 61647.LG71_11255; -.
DR   PATRIC; fig|61647.15.peg.3501; -.
DR   eggNOG; COG0280; Bacteria.
DR   eggNOG; COG0281; Bacteria.
DR   Proteomes; UP000036196; Unassembled WGS sequence.
DR   GO; GO:0016746; F:acyltransferase activity; IEA:InterPro.
DR   GO; GO:0004473; F:malate dehydrogenase (decarboxylating) (NADP+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0008948; F:oxaloacetate decarboxylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006108; P:malate metabolic process; IEA:InterPro.
DR   CDD; cd05311; NAD_bind_2_malic_enz; 1.
DR   Gene3D; 3.40.50.10950; -; 1.
DR   Gene3D; 3.40.50.10750; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
DR   Gene3D; 3.40.50.10380; Malic enzyme, N-terminal domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR   InterPro; IPR015884; Malic_enzyme_CS.
DR   InterPro; IPR012301; Malic_N_dom.
DR   InterPro; IPR037062; Malic_N_dom_sf.
DR   InterPro; IPR012302; Malic_NAD-bd.
DR   InterPro; IPR045213; Malic_NAD-bd_bact_type.
DR   InterPro; IPR012188; ME_PTA.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR042113; P_AcTrfase_dom1.
DR   InterPro; IPR042112; P_AcTrfase_dom2.
DR   InterPro; IPR002505; PTA_PTB.
DR   PANTHER; PTHR43237; NADP-DEPENDENT MALIC ENZYME; 1.
DR   PANTHER; PTHR43237:SF4; NADP-DEPENDENT MALIC ENZYME; 1.
DR   Pfam; PF00390; malic; 1.
DR   Pfam; PF03949; Malic_M; 1.
DR   Pfam; PF01515; PTA_PTB; 1.
DR   PIRSF; PIRSF036684; ME_PTA; 1.
DR   SMART; SM01274; malic; 1.
DR   SMART; SM00919; Malic_M; 1.
DR   SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR   SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00331; MALIC_ENZYMES; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000313|EMBL:KMK11089.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000036196}.
SQ   SEQUENCE   759 AA;  82681 MW;  329B88B36E34CBB2 CRC64;
     MDDQLKQSAL DFHEFPVPGK IQVSPTKPLA TQRDLALAYS PGVAAPCLEI EKDPLAAYKY
     TARGNLVAVV SNGTAVLGLG NIGALAGKPV MEGKGVLFKK FAGIDVFDIE VDETDPDKFI
     QVVSALEPTF GGINLEDIKA PECFYIEQKL REKMNIPVFH DDQHGTAIIS TAAILNGLRV
     VEKNLSDVRM VVSGAGAAAI ACMNLLVALG MQKHNIVVCD SKGVIYKDRE PNMAETKAAY
     AVEDSGKRTL DEVMDGADIF LGCSGPKVLT QEMVKRMARA PLILALANPE PEILPPLAKE
     VRPDAIICTG RSDYPNQVNN VLCFPFIFRG ALDVGATAIN EEMKLAAVHA IAELAHAEQS
     EVVASAYGDQ DLSFGPEYII PKPFDPRLIV KIAPAVAKAA MDSGVAKRPI EDFDAYEEKL
     SEFVYKTNLF MKPIFSQARK EPKRVVLAEG EENRVLHATQ ELISLGLAKP ILIGRPNVIE
     MRLQKLGLQM KPGVDFEIVN NESDPRFKEY WMEYFQIMKR KGITQEQAQR HVIANPTVIG
     AIMVQRGEAD ALICGTIGDY HEHFSVVQQL FGYRDGVHTA GAMNALLLPS GNTFIADTYV
     NDDPTPEELA EITLMAAESV RRFGIEPRVA LLSHSNFGSS NCAAATKMRT TLELVRQRDP
     ELMIDGEMHG DAALVESIRH ERMPDSPLKG AANILVMPNM EAARISYNLL RVSSSEGVTV
     GPVLMGAAKP VHILTPIASV RRIVNMVALA VVEAQTQPL
//