ID A0A0J5S0N0_9PAST Unreviewed; 545 AA.
AC A0A0J5S0N0;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=RO21_11955 {ECO:0000313|EMBL:KMK50417.1};
OS Muribacter muris.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Muribacter.
OX NCBI_TaxID=67855 {ECO:0000313|EMBL:KMK50417.1, ECO:0000313|Proteomes:UP000036270};
RN [1] {ECO:0000313|EMBL:KMK50417.1, ECO:0000313|Proteomes:UP000036270}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ackerman80-443D {ECO:0000313|EMBL:KMK50417.1,
RC ECO:0000313|Proteomes:UP000036270};
RA Christensen H., Nicklas W., Bisgaard M.;
RT "Reclassification of Actinobacillus muris as Muribacter muris.";
RL Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KMK50417.1}.
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DR EMBL; JWIZ01000119; KMK50417.1; -; Genomic_DNA.
DR RefSeq; WP_047978011.1; NZ_JWIZ01000119.1.
DR AlphaFoldDB; A0A0J5S0N0; -.
DR STRING; 67855.RO21_11955; -.
DR PATRIC; fig|67855.3.peg.243; -.
DR Proteomes; UP000036270; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 1.20.1260.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022749; D12N6_MeTrfase_N.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR038333; T1MK-like_N_sf.
DR PANTHER; PTHR42998:SF1; TYPE I RESTRICTION ENZYME HINDI METHYLASE SUBUNIT; 1.
DR PANTHER; PTHR42998; TYPE I RESTRICTION ENZYME HINDVIIP M PROTEIN-RELATED; 1.
DR Pfam; PF12161; HsdM_N; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000036270}.
FT DOMAIN 13..169
FT /note="N6 adenine-specific DNA methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12161"
FT DOMAIN 188..506
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 545 AA; 61750 MW; 85D752C031308661 CRC64;
MLTTQQAFLN DLDTRLWKAA DKLRQQLDAA NYKHIVLGFI FLKYVSDSFL EQRRKLAALF
ADPQSELYLD PAIYSEDDLK NELEERDYYA QDNIFWVPEA ARWDNIKAVA QYNIGDELPW
GAKFGGVANL IDAAFEAIEQ DNPKLKGKIQ RIAGYKVQAD TLIGLVDLFS DTHFSQPTFD
GKPVHLAAKD ILGHVYEYFL GQFALAEGKK GGQYFTPKSI VTLIVEMLEP YEGRIYDPAM
GSGGFFVQTE RFIESHQGKT PHASRNKNIA IYGQEYNPTT WQLAAMNMAI RGIEFDFGNQ
NADTFTNPQH LDKKMDFIMA NPPFNMKEWW SESLAQDPRW QYGTPPAGNA NFAWLQHMIY
HLSPKGRMAL LLANGSMSSN TNNEGEIRKN ILRADLVEAM VALPSQLFTN TQIPACIWIL
NKAKARKGEV LFIDARQIGY MKDRVLRDFT PDDIAKIAQT YHSWQKADGY QNQAAYCYSA
TLDDIAKNDY VLPPGRYVGT AEQEDDGVPF AEKMQQLTAL LNEQFKQSAE LEVKIKANLG
GLGYE
//
