ID A0A0J6CPN2_9BACI Unreviewed; 796 AA.
AC A0A0J6CPN2;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=Beta-lactam antibiotic acylase {ECO:0000313|EMBL:KMM38226.1};
GN ORFNames=AB986_02610 {ECO:0000313|EMBL:KMM38226.1};
OS Alkalihalobacillus macyae.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Alkalihalobacillus.
OX NCBI_TaxID=157733 {ECO:0000313|EMBL:KMM38226.1, ECO:0000313|Proteomes:UP000035996};
RN [1] {ECO:0000313|EMBL:KMM38226.1, ECO:0000313|Proteomes:UP000035996}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 16346 {ECO:0000313|EMBL:KMM38226.1,
RC ECO:0000313|Proteomes:UP000035996};
RA Liu B., Wang J., Zhu Y., Liu G., Chen Q., Zheng C., Che J., Ge C., Shi H.,
RA Pan Z., Liu X.;
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|PIRSR:PIRSR001227-2};
CC Note=Binds 1 Ca(2+) ion per dimer. {ECO:0000256|PIRSR:PIRSR001227-2};
CC -!- SIMILARITY: Belongs to the peptidase S45 family.
CC {ECO:0000256|ARBA:ARBA00006586}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KMM38226.1}.
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DR EMBL; LELK01000001; KMM38226.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0J6CPN2; -.
DR STRING; 157733.AB986_02610; -.
DR PATRIC; fig|157733.3.peg.2735; -.
DR Proteomes; UP000035996; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016811; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:InterPro.
DR CDD; cd03747; Ntn_PGA_like; 1.
DR Gene3D; 1.10.1400.10; -; 1.
DR Gene3D; 2.30.120.10; -; 1.
DR Gene3D; 3.60.20.10; Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1; 1.
DR Gene3D; 1.10.439.10; Penicillin Amidohydrolase, domain 1; 1.
DR InterPro; IPR029055; Ntn_hydrolases_N.
DR InterPro; IPR014395; Pen/GL7ACA/AHL_acylase.
DR InterPro; IPR043147; Penicillin_amidase_A-knob.
DR InterPro; IPR023343; Penicillin_amidase_dom1.
DR InterPro; IPR043146; Penicillin_amidase_N_B-knob.
DR InterPro; IPR002692; S45.
DR PANTHER; PTHR34218:SF4; ACYL-HOMOSERINE LACTONE ACYLASE QUIP; 1.
DR PANTHER; PTHR34218; PEPTIDASE S45 PENICILLIN AMIDASE; 1.
DR Pfam; PF01804; Penicil_amidase; 1.
DR PIRSF; PIRSF001227; Pen_acylase; 1.
DR SUPFAM; SSF56235; N-terminal nucleophile aminohydrolases (Ntn hydrolases); 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|PIRSR:PIRSR001227-2};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR001227-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000035996};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT TRANSMEM 20..43
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT ACT_SITE 262
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR001227-1"
FT BINDING 334
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR001227-2"
FT BINDING 337
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR001227-2"
SQ SEQUENCE 796 AA; 89935 MW; 6FD0FEDF466EC0F7 CRC64;
MRDAMGTPIT PVEQVQRSRW PLYILVSVLV LLLLAGSIAF WFIQKSAPET TGEIVLPPLN
APVSIYRDNA GVPHIEASSS KDLFIAQGYV TAQDRMFQMD LSRRQASGTL SEVIGEATID
KDKFFRTLGL RRAAEASYDE YSDEAKQILQ WYADGVNAYL TQAKSERSLP LEFTFANYEP
NEWHPIDSLT IGKYMSFDLG GHWEGQAFRY YLLQNFTEEE AMDLFPSYPE DGETVIQEAQ
KNSIDVTKSF ANAVVPDPFN GSNNWVISGE KTASGKPLLA NDPHLGLGTP PIWYETHLNS
PEYNVNGVIF AGVPGIIVGR NESIAWGVTN VGPDVQDLYI EKRNPNQSNE FLYNDKWEKA
QVEDETIFVK DAEPIPYQVA ITRHGPILSE FAYDDQSDTA LSLRWTALDP SNELEAVLMM
NKANNWDEFK KALTFFHTPA QNFVFASTDG TIAYRANGLI PIRKKGDSML PVPGWNDEYE
WEGYIPWNDL PTIVNPEEGF ISTANNKITT EDYPYHITHT WAQPYRQERI REVLLQDNEL
DVKDMMKLQN DFVNLQGKEF TPILISGLIQ KELTSFEKDA LKLLKNWNFI DEKDQAAPLL
FHVWLVEIEK KLFKGTIDKE MMSLFEGKSQ IVDQLIRRAS EGNPGPWVMN AGGFESLLTQ
SYKAAVDRAI KLQGDSPEEW EWGTFHSVPF EHPLGAIKPL NLLFNPDEHA MSGSRVTVGA
AGWSTSTGLV NHGAPWRGIT DLSTIETSYN VVSPGQSGYV FSKWYDNQIE DWVNGEYHIT
QLKGYETNSD HLILKP
//