GenomeNet

Database: UniProt
Entry: A0A0J6CPN2_9BACI
LinkDB: A0A0J6CPN2_9BACI
Original site: A0A0J6CPN2_9BACI 
ID   A0A0J6CPN2_9BACI        Unreviewed;       796 AA.
AC   A0A0J6CPN2;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   SubName: Full=Beta-lactam antibiotic acylase {ECO:0000313|EMBL:KMM38226.1};
GN   ORFNames=AB986_02610 {ECO:0000313|EMBL:KMM38226.1};
OS   Alkalihalobacillus macyae.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Alkalihalobacillus.
OX   NCBI_TaxID=157733 {ECO:0000313|EMBL:KMM38226.1, ECO:0000313|Proteomes:UP000035996};
RN   [1] {ECO:0000313|EMBL:KMM38226.1, ECO:0000313|Proteomes:UP000035996}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 16346 {ECO:0000313|EMBL:KMM38226.1,
RC   ECO:0000313|Proteomes:UP000035996};
RA   Liu B., Wang J., Zhu Y., Liu G., Chen Q., Zheng C., Che J., Ge C., Shi H.,
RA   Pan Z., Liu X.;
RL   Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|PIRSR:PIRSR001227-2};
CC       Note=Binds 1 Ca(2+) ion per dimer. {ECO:0000256|PIRSR:PIRSR001227-2};
CC   -!- SIMILARITY: Belongs to the peptidase S45 family.
CC       {ECO:0000256|ARBA:ARBA00006586}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KMM38226.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; LELK01000001; KMM38226.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0J6CPN2; -.
DR   STRING; 157733.AB986_02610; -.
DR   PATRIC; fig|157733.3.peg.2735; -.
DR   Proteomes; UP000035996; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016811; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:InterPro.
DR   CDD; cd03747; Ntn_PGA_like; 1.
DR   Gene3D; 1.10.1400.10; -; 1.
DR   Gene3D; 2.30.120.10; -; 1.
DR   Gene3D; 3.60.20.10; Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1; 1.
DR   Gene3D; 1.10.439.10; Penicillin Amidohydrolase, domain 1; 1.
DR   InterPro; IPR029055; Ntn_hydrolases_N.
DR   InterPro; IPR014395; Pen/GL7ACA/AHL_acylase.
DR   InterPro; IPR043147; Penicillin_amidase_A-knob.
DR   InterPro; IPR023343; Penicillin_amidase_dom1.
DR   InterPro; IPR043146; Penicillin_amidase_N_B-knob.
DR   InterPro; IPR002692; S45.
DR   PANTHER; PTHR34218:SF4; ACYL-HOMOSERINE LACTONE ACYLASE QUIP; 1.
DR   PANTHER; PTHR34218; PEPTIDASE S45 PENICILLIN AMIDASE; 1.
DR   Pfam; PF01804; Penicil_amidase; 1.
DR   PIRSF; PIRSF001227; Pen_acylase; 1.
DR   SUPFAM; SSF56235; N-terminal nucleophile aminohydrolases (Ntn hydrolases); 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|PIRSR:PIRSR001227-2};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR001227-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000035996};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT   TRANSMEM        20..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   ACT_SITE        262
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001227-1"
FT   BINDING         334
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001227-2"
FT   BINDING         337
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001227-2"
SQ   SEQUENCE   796 AA;  89935 MW;  6FD0FEDF466EC0F7 CRC64;
     MRDAMGTPIT PVEQVQRSRW PLYILVSVLV LLLLAGSIAF WFIQKSAPET TGEIVLPPLN
     APVSIYRDNA GVPHIEASSS KDLFIAQGYV TAQDRMFQMD LSRRQASGTL SEVIGEATID
     KDKFFRTLGL RRAAEASYDE YSDEAKQILQ WYADGVNAYL TQAKSERSLP LEFTFANYEP
     NEWHPIDSLT IGKYMSFDLG GHWEGQAFRY YLLQNFTEEE AMDLFPSYPE DGETVIQEAQ
     KNSIDVTKSF ANAVVPDPFN GSNNWVISGE KTASGKPLLA NDPHLGLGTP PIWYETHLNS
     PEYNVNGVIF AGVPGIIVGR NESIAWGVTN VGPDVQDLYI EKRNPNQSNE FLYNDKWEKA
     QVEDETIFVK DAEPIPYQVA ITRHGPILSE FAYDDQSDTA LSLRWTALDP SNELEAVLMM
     NKANNWDEFK KALTFFHTPA QNFVFASTDG TIAYRANGLI PIRKKGDSML PVPGWNDEYE
     WEGYIPWNDL PTIVNPEEGF ISTANNKITT EDYPYHITHT WAQPYRQERI REVLLQDNEL
     DVKDMMKLQN DFVNLQGKEF TPILISGLIQ KELTSFEKDA LKLLKNWNFI DEKDQAAPLL
     FHVWLVEIEK KLFKGTIDKE MMSLFEGKSQ IVDQLIRRAS EGNPGPWVMN AGGFESLLTQ
     SYKAAVDRAI KLQGDSPEEW EWGTFHSVPF EHPLGAIKPL NLLFNPDEHA MSGSRVTVGA
     AGWSTSTGLV NHGAPWRGIT DLSTIETSYN VVSPGQSGYV FSKWYDNQIE DWVNGEYHIT
     QLKGYETNSD HLILKP
//
DBGET integrated database retrieval system