ID A0A0J6W5L2_9MYCO Unreviewed; 159 AA.
AC A0A0J6W5L2;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Peptide methionine sulfoxide reductase MsrB {ECO:0000256|HAMAP-Rule:MF_01400};
DE EC=1.8.4.12 {ECO:0000256|HAMAP-Rule:MF_01400};
DE AltName: Full=Peptide-methionine (R)-S-oxide reductase {ECO:0000256|HAMAP-Rule:MF_01400};
GN Name=msrB_1 {ECO:0000313|EMBL:KMO77078.1};
GN Synonyms=msrB {ECO:0000256|HAMAP-Rule:MF_01400,
GN ECO:0000313|EMBL:TDL11525.1};
GN ORFNames=EUA04_00435 {ECO:0000313|EMBL:TDL11525.1}, MOBUDSM44075_02118
GN {ECO:0000313|EMBL:KMO77078.1}, WN67_12640
GN {ECO:0000313|EMBL:KKF01663.1};
OS Mycolicibacterium obuense.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=1807 {ECO:0000313|EMBL:KMO77078.1, ECO:0000313|Proteomes:UP000036313};
RN [1] {ECO:0000313|EMBL:KMO77078.1, ECO:0000313|Proteomes:UP000036313}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44075 {ECO:0000313|EMBL:KMO77078.1,
RC ECO:0000313|Proteomes:UP000036313};
RX PubMed=26079817; DOI=10.1093/gbe/evv111;
RA Das S., Pettersson B.M., Behra P.R., Ramesh M., Dasgupta S.,
RA Bhattacharya A., Kirsebom L.A.;
RT "Characterization of Three Mycobacterium spp. with Potential Use in
RT Bioremediation by Genome Sequencing and Comparative Genomics.";
RL Genome Biol. Evol. 7:1871-1886(2015).
RN [2] {ECO:0000313|EMBL:KKF01663.1, ECO:0000313|Proteomes:UP000034150}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UC1 {ECO:0000313|EMBL:KKF01663.1,
RC ECO:0000313|Proteomes:UP000034150};
RA Greninger A.L., Cunningham G., Chiu C.Y., Miller S.;
RT "Genome sequence of Mycobacterium obuense UC1.";
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:TDL11525.1, ECO:0000313|Proteomes:UP000294952}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=22DIII {ECO:0000313|EMBL:TDL11525.1,
RC ECO:0000313|Proteomes:UP000294952};
RA Tiago I., Alarico S., Pereira S.G., Coelho C., Maranha A., Empadinhas N.;
RT "High-quality-draft genome sequences of five non-tuberculosis
RT mycobacteriaceae isolated from a nosocomial environment.";
RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[thioredoxin]-disulfide + H2O + L-methionyl-[protein] =
CC [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein];
CC Xref=Rhea:RHEA:24164, Rhea:RHEA-COMP:10698, Rhea:RHEA-COMP:10700,
CC Rhea:RHEA-COMP:12313, Rhea:RHEA-COMP:12314, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:16044, ChEBI:CHEBI:29950, ChEBI:CHEBI:45764,
CC ChEBI:CHEBI:50058; EC=1.8.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001795, ECO:0000256|HAMAP-
CC Rule:MF_01400};
CC -!- SIMILARITY: Belongs to the MsrB Met sulfoxide reductase family.
CC {ECO:0000256|HAMAP-Rule:MF_01400}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|HAMAP-Rule:MF_01400}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KMO77078.1}.
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DR EMBL; LAUZ02000045; KKF01663.1; -; Genomic_DNA.
DR EMBL; JYNU01000011; KMO77078.1; -; Genomic_DNA.
DR EMBL; SDLP01000001; TDL11525.1; -; Genomic_DNA.
DR RefSeq; WP_046363364.1; NZ_SDLP01000001.1.
DR STRING; 1807.MOBUDSM44075_02118; -.
DR PATRIC; fig|1807.13.peg.3715; -.
DR OrthoDB; 9785497at2; -.
DR Proteomes; UP000034150; Unassembled WGS sequence.
DR Proteomes; UP000036313; Unassembled WGS sequence.
DR Proteomes; UP000294952; Unassembled WGS sequence.
DR GO; GO:0033743; F:peptide-methionine (R)-S-oxide reductase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030091; P:protein repair; IEA:InterPro.
DR GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR Gene3D; 2.170.150.20; Peptide methionine sulfoxide reductase; 1.
DR HAMAP; MF_01400; MsrB; 1.
DR InterPro; IPR028427; Met_Sox_Rdtase_MsrB.
DR InterPro; IPR002579; Met_Sox_Rdtase_MsrB_dom.
DR InterPro; IPR011057; Mss4-like_sf.
DR NCBIfam; TIGR00357; peptide-methionine (R)-S-oxide reductase MsrB; 1.
DR PANTHER; PTHR10173; METHIONINE SULFOXIDE REDUCTASE; 1.
DR PANTHER; PTHR10173:SF52; METHIONINE-R-SULFOXIDE REDUCTASE B3; 1.
DR Pfam; PF01641; SelR; 1.
DR SUPFAM; SSF51316; Mss4-like; 1.
DR PROSITE; PS51790; MSRB; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002, ECO:0000256|HAMAP-
KW Rule:MF_01400}.
FT DOMAIN 8..131
FT /note="MsrB"
FT /evidence="ECO:0000259|PROSITE:PS51790"
FT ACT_SITE 120
FT /note="Nucleophile"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01400"
SQ SEQUENCE 159 AA; 17973 MW; EFBAD1656E3CCD45 CRC64;
MTQTYNRNPD AIGALSPEQY HVTQQNGTER PFTGEYWDNH EPGLYVDVVS GEPLFASVDK
FESGSGWPSF TRPVDAENVI RKRDFSHLMM RTEVRSAHGD SHLGHVFTDG PREAGGLRYC
INSAALRFVH LDDLEAQGYG QYRELFTEST VTESEEERA
//
