ID A0A0J6XDP8_9ACTN Unreviewed; 690 AA.
AC A0A0J6XDP8;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=phospholipase C {ECO:0000256|ARBA:ARBA00012018};
DE EC=3.1.4.3 {ECO:0000256|ARBA:ARBA00012018};
GN ORFNames=ACS04_31480 {ECO:0000313|EMBL:KMO94030.1};
OS Streptomyces roseus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=66430 {ECO:0000313|EMBL:KMO94030.1, ECO:0000313|Proteomes:UP000035932};
RN [1] {ECO:0000313|EMBL:KMO94030.1, ECO:0000313|Proteomes:UP000035932}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 31245 {ECO:0000313|EMBL:KMO94030.1,
RC ECO:0000313|Proteomes:UP000035932};
RA Cruz-Morales P., Martinez-Guerrero C., Morales-Escalante M.A.,
RA Yanez-Guerra L.A., Kopp J.F., Feldmann J., Ramos-Aboites H.E.,
RA Barona-Gomez F.;
RT "Recapitulation of the evolution of biosynthetic gene clusters reveals
RT hidden chemical diversity on bacterial genomes.";
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-
CC sn-glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:10604,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815,
CC ChEBI:CHEBI:57643, ChEBI:CHEBI:295975; EC=3.1.4.3;
CC Evidence={ECO:0000256|ARBA:ARBA00023550};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10605;
CC Evidence={ECO:0000256|ARBA:ARBA00023550};
CC -!- SUBCELLULAR LOCATION: Secreted, cell wall
CC {ECO:0000256|ARBA:ARBA00004191}.
CC -!- SIMILARITY: Belongs to the bacterial phospholipase C family.
CC {ECO:0000256|ARBA:ARBA00009717}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KMO94030.1}.
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DR EMBL; LFML01000150; KMO94030.1; -; Genomic_DNA.
DR RefSeq; WP_048480233.1; NZ_LFML01000150.1.
DR AlphaFoldDB; A0A0J6XDP8; -.
DR STRING; 66430.ACS04_31480; -.
DR PATRIC; fig|66430.4.peg.2628; -.
DR OrthoDB; 4181857at2; -.
DR Proteomes; UP000035932; Unassembled WGS sequence.
DR GO; GO:0034480; F:phosphatidylcholine phospholipase C activity; IEA:UniProtKB-EC.
DR GO; GO:0016042; P:lipid catabolic process; IEA:InterPro.
DR CDD; cd16014; PLC; 1.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 2.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR017767; Bact_PC-PLC.
DR InterPro; IPR007312; Phosphoesterase.
DR InterPro; IPR008475; PLipase_C_C.
DR InterPro; IPR006311; TAT_signal.
DR NCBIfam; TIGR03396; PC_PLC; 1.
DR PANTHER; PTHR31956:SF8; ACID PHOSPHATASE PHOA (AFU_ORTHOLOGUE AFUA_1G03570); 1.
DR PANTHER; PTHR31956; NON-SPECIFIC PHOSPHOLIPASE C4-RELATED; 1.
DR Pfam; PF04185; Phosphoesterase; 1.
DR Pfam; PF05506; PLipase_C_C; 2.
DR PROSITE; PS51318; TAT; 1.
PE 3: Inferred from homology;
KW Cell wall {ECO:0000256|ARBA:ARBA00022512};
KW Reference proteome {ECO:0000313|Proteomes:UP000035932};
KW Secreted {ECO:0000256|ARBA:ARBA00022512};
KW Virulence {ECO:0000256|ARBA:ARBA00023026}.
FT DOMAIN 499..582
FT /note="Bacterial phospholipase C C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05506"
FT DOMAIN 590..670
FT /note="Bacterial phospholipase C C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05506"
FT REGION 460..491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 690 AA; 74598 MW; 02E8FB93B0C5EA39 CRC64;
MAELNRRRFL QLTGGAAALT LLNESIARAA AIPAQGTTGT IADVEHVVVL MQENRSFDHY
FGALRGIRGF GDPRPVTLPS GKSVWHQTDN AGKETLPFRP PSDDLGMEYL QGLNHDWAGG
QSAFNKGKYD NWVPAKTPAT MAHLTREDIP FHYALADAFT ICDAYHCSFI GSTDPNRYYL
WSGHTGNDGK GGGPVLNNAE AGYGWTTYPE RLEQAGISWK VYQDIGNGLD AAGSWGWIND
AFRGNYGDNS LLYFNNYRTA QPGDPLYEKA RTGTDARTGE GYFDRLRADV AAGTLPQVSW
IAAPEAFSEH SNWPANFGAW YIAQVLDALT SNPDVWARTA LFITYDENDG FFDHVVPPYA
PANANQGLST VSTTLDVFPG AAGYVAGPYG LGPRVPMLVV SPWSTGGYSC SETFDHTSVI
RFMEKRFGVR EPNISPWRRA VCGDLTSAFD FARKDTGTVR LPDTGPWEPQ DRERHPNFLA
TPPAVGTMPR QEKGLCNTRP LKYAPYVDGA ALTGEGKFRL TFSGGPDLGA QFYVTSGNRT
DAPWTYTTEA GKSVSDTWNT AYSTGATDLT VHGPNGFLRG FRNPGTAPGP EVTARHNAAT
GNLDLTLTNA GASTATLTVT NAYGGGPKRL TVAKGATLTY SVPLRSTRRW YDVTVTASEF
PDFGRRFAGK VETGAAGLSD PGILTEQGGS
//
