ID A0A0J6XQ10_LACRH Unreviewed; 273 AA.
AC A0A0J6XQ10; A0A2A5L8E5;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase {ECO:0000256|ARBA:ARBA00019161};
DE EC=2.7.1.49 {ECO:0000256|ARBA:ARBA00012135};
DE EC=2.7.4.7 {ECO:0000256|ARBA:ARBA00012963};
DE AltName: Full=Hydroxymethylpyrimidine kinase {ECO:0000256|ARBA:ARBA00042102};
DE AltName: Full=Hydroxymethylpyrimidine phosphate kinase {ECO:0000256|ARBA:ARBA00043176};
GN Name=thiD {ECO:0000313|EMBL:NVO87472.1};
GN ORFNames=BGK71_02865 {ECO:0000313|EMBL:ASX16414.1}, FOS38_07165
GN {ECO:0000313|EMBL:MBB1164721.1}, GFB59_03635
GN {ECO:0000313|EMBL:QPB49080.1}, HWN39_03050
GN {ECO:0000313|EMBL:NVO87472.1}, PY91_06780
GN {ECO:0000313|EMBL:OAU24029.1};
OS Lacticaseibacillus rhamnosus (Lactobacillus rhamnosus).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lacticaseibacillus.
OX NCBI_TaxID=47715 {ECO:0000313|EMBL:NVO87472.1, ECO:0000313|Proteomes:UP000542889};
RN [1] {ECO:0000313|EMBL:OAU24029.1, ECO:0000313|Proteomes:UP000078528}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Lrh22 {ECO:0000313|EMBL:OAU24029.1,
RC ECO:0000313|Proteomes:UP000078528};
RA Ceapa C., Ritari J.;
RT "The variable regions of Lactobacillus rhamnosus genomes reveal the dynamic
RT evolution of metabolic and host-adaptation repertoires.";
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ASX16414.1, ECO:0000313|Proteomes:UP000215843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LR5 {ECO:0000313|EMBL:ASX16414.1,
RC ECO:0000313|Proteomes:UP000215843};
RA Nam Y.-D., Kang J., Chung W.-H.;
RT "Complete genome sequence of Lactobacillus rhamnosus LR5.";
RL Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:MBB1164721.1, ECO:0000313|Proteomes:UP000551634}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DPC 7102 {ECO:0000313|EMBL:MBB1164721.1,
RC ECO:0000313|Proteomes:UP000551634};
RA Leeuwendaal N., Stanton C., O'Toole P.W., Beresford T.;
RT "Annotated Genomes of Lactobacillus rhamnosus DPC 7102 and Lactobacillus
RT paracasei DCP 7150.";
RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:QPB49080.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=TK-F8B {ECO:0000313|EMBL:QPB49080.1};
RA Chen H.;
RT "Whole genome of Lactobacillus rhamnosus TK-F8B.";
RL Submitted (OCT-2019) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:NVO87472.1, ECO:0000313|Proteomes:UP000542889}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=QC {ECO:0000313|EMBL:NVO87472.1,
RC ECO:0000313|Proteomes:UP000542889};
RA Yi H., Jin M.;
RT "Lactobacillus rhamnosus QC,genome.";
RL Submitted (JUN-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ATP = 4-
CC amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + ADP;
CC Xref=Rhea:RHEA:19893, ChEBI:CHEBI:30616, ChEBI:CHEBI:57841,
CC ChEBI:CHEBI:58354, ChEBI:CHEBI:456216; EC=2.7.4.7;
CC Evidence={ECO:0000256|ARBA:ARBA00000565};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP = 4-amino-2-
CC methyl-5-(phosphooxymethyl)pyrimidine + ADP + H(+);
CC Xref=Rhea:RHEA:23096, ChEBI:CHEBI:15378, ChEBI:CHEBI:16892,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:58354, ChEBI:CHEBI:456216;
CC EC=2.7.1.49; Evidence={ECO:0000256|ARBA:ARBA00000151};
CC -!- PATHWAY: Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-
CC amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-
CC ribosyl)imidazole: step 2/3. {ECO:0000256|ARBA:ARBA00037917}.
CC -!- SIMILARITY: Belongs to the ThiD family.
CC {ECO:0000256|ARBA:ARBA00009879}.
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DR EMBL; CP017063; ASX16414.1; -; Genomic_DNA.
DR EMBL; VLHP01000006; MBB1164721.1; -; Genomic_DNA.
DR EMBL; JABXWP010000003; NVO87472.1; -; Genomic_DNA.
DR EMBL; JTIH01000007; OAU24029.1; -; Genomic_DNA.
DR EMBL; CP045586; QPB49080.1; -; Genomic_DNA.
DR RefSeq; WP_005684105.1; NZ_VRTQ01000001.1.
DR STRING; 47715.AWJ15_13485; -.
DR GeneID; 69831172; -.
DR eggNOG; COG0351; Bacteria.
DR OrthoDB; 9810880at2; -.
DR Proteomes; UP000078528; Unassembled WGS sequence.
DR Proteomes; UP000215843; Chromosome.
DR Proteomes; UP000542889; Unassembled WGS sequence.
DR Proteomes; UP000551634; Unassembled WGS sequence.
DR Proteomes; UP000663681; Chromosome.
DR GO; GO:0008902; F:hydroxymethylpyrimidine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0008972; F:phosphomethylpyrimidine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0009228; P:thiamine biosynthetic process; IEA:InterPro.
DR CDD; cd01169; HMPP_kinase; 1.
DR Gene3D; 3.40.1190.20; -; 1.
DR InterPro; IPR004399; HMP/HMP-P_kinase_dom.
DR InterPro; IPR013749; PM/HMP-P_kinase-1.
DR InterPro; IPR029056; Ribokinase-like.
DR NCBIfam; TIGR00097; HMP-P_kinase; 1.
DR PANTHER; PTHR20858:SF17; HYDROXYMETHYLPYRIMIDINE_PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED; 1.
DR PANTHER; PTHR20858; PHOSPHOMETHYLPYRIMIDINE KINASE; 1.
DR Pfam; PF08543; Phos_pyr_kin; 1.
DR SUPFAM; SSF53613; Ribokinase-like; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000313|EMBL:NVO87472.1};
KW Transferase {ECO:0000313|EMBL:NVO87472.1}.
FT DOMAIN 15..262
FT /note="Pyridoxamine kinase/Phosphomethylpyrimidine kinase"
FT /evidence="ECO:0000259|Pfam:PF08543"
SQ SEQUENCE 273 AA; 29412 MW; F01F35409D5486DB CRC64;
MANEFPQVMT IGGTDSDGSA GVQADLHSFF MRGVYGATVL TAAVAGNSYG IQDSMVMPVP
FIDAQFKSLA ADLKIKAAKT GMLADKALVQ AIIKNWQQYD FGALVVDPVI ITKHGAMLLE
QDAYDAVKNE LIPLATVVTP NHYEAEHLTG MKLDTDAATE AAAHQLQASG AKNVVLKGAH
DDPTQKEVRD FVLLESGKSF WLSEPYHDTD RVNGTGDTLS AVITAEIGKG NDVEDAIRIA
KRFTNQAIGH PIPVGHKYGP INHWANQIVY PQQ
//
