ID A0A0J6XRM1_9ACTN Unreviewed; 518 AA.
AC A0A0J6XRM1;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Peptidase S8 {ECO:0000313|EMBL:KMO97443.1};
GN ORFNames=ACS04_13200 {ECO:0000313|EMBL:KMO97443.1};
OS Streptomyces roseus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=66430 {ECO:0000313|EMBL:KMO97443.1, ECO:0000313|Proteomes:UP000035932};
RN [1] {ECO:0000313|EMBL:KMO97443.1, ECO:0000313|Proteomes:UP000035932}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 31245 {ECO:0000313|EMBL:KMO97443.1,
RC ECO:0000313|Proteomes:UP000035932};
RA Cruz-Morales P., Martinez-Guerrero C., Morales-Escalante M.A.,
RA Yanez-Guerra L.A., Kopp J.F., Feldmann J., Ramos-Aboites H.E.,
RA Barona-Gomez F.;
RT "Recapitulation of the evolution of biosynthetic gene clusters reveals
RT hidden chemical diversity on bacterial genomes.";
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase S8 family.
CC {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240,
CC ECO:0000256|RuleBase:RU003355}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KMO97443.1}.
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DR EMBL; LFML01000049; KMO97443.1; -; Genomic_DNA.
DR RefSeq; WP_048476749.1; NZ_LFML01000049.1.
DR AlphaFoldDB; A0A0J6XRM1; -.
DR STRING; 66430.ACS04_13200; -.
DR PATRIC; fig|66430.4.peg.5068; -.
DR OrthoDB; 9813435at2; -.
DR Proteomes; UP000035932; Unassembled WGS sequence.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR PANTHER; PTHR43806:SF59; CEREVISIN-RELATED; 1.
DR PANTHER; PTHR43806; PEPTIDASE S8; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00136; SUBTILASE_ASP; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000035932};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..37
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 38..518
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5005284862"
FT DOMAIN 183..477
FT /note="Peptidase S8/S53"
FT /evidence="ECO:0000259|Pfam:PF00082"
FT ACT_SITE 191
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 234
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 441
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 518 AA; 53035 MW; 30950509FC1E58F6 CRC64;
MAQLGSRSPE WRGRLAVPVG LALTASLAFL PSVAASAAPL GSTAAGTAAA AKPDTTGPKL
SYVANLTTYA SVKAAKKAVE RAGGTVVTSY EQIGVVVAHS QNPDFAKQLR AQRSLFVSVG
ATRTAPLQTV ATTEEGTTQK LGAADAAKAA AAATDGQEPL EPNQWDLRAI KADQAHKIND
GSRDVTVGVI DTGVDDTHPD LAPNFSKSQS ANCVGGVADT TDGAWRPYPD GSDHGTHVAG
TIAAARNGIG VAGVAPGVQV AAIKVSEPGT SLFFTEAVVC GFMFAAEKGI EVTNNSYYVD
PWLYNCKADD DQKALVEALG RATKYAERKG VLSVASAGNS NHDLASNAIV DDSSPDDGTP
VPRTIDPHVC LDIPTQLPGV VTVSATGNQG VRSYYSSFGL GVVDVAAPGG DKWQIPATPD
ANGRVLSTLP GGGYGYKQGT SMAGPHVAGV AALLKSAHPK ATPSQLQAML KAQATKTACP
EKIYDATGAL VDATTCQSKW GQTGYYGYGV VDALKAVK
//
