ID   A0A0J6XSH4_9ACTN        Unreviewed;      1311 AA.
AC   A0A0J6XSH4;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   SubName: Full=ATP-dependent helicase {ECO:0000313|EMBL:KMO97237.1};
GN   ORFNames=ACS04_13835 {ECO:0000313|EMBL:KMO97237.1};
OS   Streptomyces roseus.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=66430 {ECO:0000313|EMBL:KMO97237.1, ECO:0000313|Proteomes:UP000035932};
RN   [1] {ECO:0000313|EMBL:KMO97237.1, ECO:0000313|Proteomes:UP000035932}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 31245 {ECO:0000313|EMBL:KMO97237.1,
RC   ECO:0000313|Proteomes:UP000035932};
RA   Cruz-Morales P., Martinez-Guerrero C., Morales-Escalante M.A.,
RA   Yanez-Guerra L.A., Kopp J.F., Feldmann J., Ramos-Aboites H.E.,
RA   Barona-Gomez F.;
RT   "Recapitulation of the evolution of biosynthetic gene clusters reveals
RT   hidden chemical diversity on bacterial genomes.";
RL   Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KMO97237.1}.
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DR   EMBL; LFML01000052; KMO97237.1; -; Genomic_DNA.
DR   RefSeq; WP_048476885.1; NZ_LFML01000052.1.
DR   STRING; 66430.ACS04_13835; -.
DR   PATRIC; fig|66430.4.peg.5200; -.
DR   OrthoDB; 9805617at2; -.
DR   Proteomes; UP000035932; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR   CDD; cd17989; DEXHc_HrpA; 1.
DR   CDD; cd18791; SF2_C_RHA; 1.
DR   Gene3D; 1.20.120.1080; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR048333; HA2_WH.
DR   InterPro; IPR007502; Helicase-assoc_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR024590; HrpA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010222; RNA_helicase_HrpA.
DR   NCBIfam; TIGR01967; DEAH_box_HrpA; 1.
DR   PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR   PANTHER; PTHR18934:SF83; PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF11898; DUF3418; 1.
DR   Pfam; PF21010; HA2_C; 1.
DR   Pfam; PF04408; HA2_N; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF07717; OB_NTP_bind; 1.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00847; HA2; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Helicase {ECO:0000313|EMBL:KMO97237.1};
KW   Hydrolase {ECO:0000313|EMBL:KMO97237.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000035932}.
FT   DOMAIN          83..247
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          275..442
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
SQ   SEQUENCE   1311 AA;  148183 MW;  CFF9CE1BE5055EA0 CRC64;
     MSTSFAALQT LLGEISLRDA HRLGRRLEGA RRIRKPEAKQ AVLDEIAAEA EKAAARLAGR
     ASRMPEVTYP ENLPVSQKKD EIAEAIRDHQ VVIVAGETGS GKTTQIPKIC MELGRGVRGM
     IGHTQPRRIA ARTVAERIAE ELDSEIGRTV GWKVRFTDQV DQDATFVKLM TDGILLAEIQ
     TDRELRAYDT IIIDEAHERS LNIDFLLGYL SQLLPKRPDL KVVITSATID PERFSRHFGD
     APIVEVSGRT YPVEVRYRPL LEEDSEESDR DQITAICEAV DELQSEGPGD VLVFLSGERE
     IRDTADALNK RNLRFTEVLP LYARLSHAEQ HRVFQQHTGR RIVLATNVAE TSLTVPGIKY
     VIDPGTARIS RYSHRTKVQR LPIERISQAS ANQRKGRCGR TSDGICIRLY SEDDFLSRPE
     FTDAEILRTN LASVILQMTA AGLGEIEKFP FIDPPDHRNI RDGVQLLQEL GALDPAEKDP
     KKRLTPMGRQ LSQLPVDPRL ARMVVEADKN NCVREVMVIA AALSIQDPRE RPSDKQTQAD
     QNHARFKDET SDFLSFLNMW RYVREQQKER GSSSFRRMCK QEYLNFLRIR EWQDIYSQLR
     TVAKGMGIHV NEGDAPETSV HISLLAGLLS HIGLKDTDKN EYLGARSAKF AIFPGSALFK
     KQPKFLMSAE LVETSRLWAR VNAKVEPEWV EPLAQHLIKR TYSEPHWEKD QAAVMAYEKV
     TLYGAPIVAQ RKINYGRIDA EVSRELFIRN ALVEGDWRTH HKFYADNRKL LTEVEELENR
     ARRRDIVVDD ETLFDFYDQR IPEHVVSGAH FDSWWKHKKR EEPELLDFER EMLLTEKAAG
     VTKADYPDSW RQGQLKFRVT YQFEPGADAD GVTVHIPLQV LNQVTDEGFD WQIPGLREEV
     VTELIRSLPK PIRRHYVPAP NFATRFLATA VPLQEPLPVT LARELQRMVG VPVSAEDFDL
     GRIPDHLKIT FRIVDERRKN LAEDKDLEAL RLKLKPKARQ ALSKAAAATA ERAGGESLER
     TGLTDWTIGT LTKVFETRRA GQPVKAYPAL VDEGAGVSVR LFDTEAEQQQ AMWLGTRRLI
     LLNIPVNPAK FASDHLTNQQ KLALPRNPHG SIQALFDDCA TAAADKLIAD HGGPAWDEAA
     FRALYEAVRA DLVDTTVRTV SQVQQVLAAW QACERRLKAT NSLALVANVQ DVRTQLAALV
     PPGFVTLTGL RRLGDLMRYL VAVDRRLQQM PTGAQRDTTR MQKVHEMQDE YAWLLEQLPK
     GRPVPSAVTD IRWMIEELRV SYFAHALGTA YPISDKRIVK AVDAAAPGPA R
//