ID A0A0J6Y763_COCIT Unreviewed; 3795 AA.
AC A0A0J6Y763;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Transcription-associated protein 1 {ECO:0000313|EMBL:KMP03585.1};
GN ORFNames=CIRG_03277 {ECO:0000313|EMBL:KMP03585.1};
OS Coccidioides immitis RMSCC 2394.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=404692 {ECO:0000313|EMBL:KMP03585.1, ECO:0000313|Proteomes:UP000054565};
RN [1] {ECO:0000313|Proteomes:UP000054565}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RMSCC 2394 {ECO:0000313|Proteomes:UP000054565};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
CC -!- FUNCTION: Serine/threonine protein kinase which activates checkpoint
CC signaling upon genotoxic stresses such as ionizing radiation (IR),
CC ultraviolet light (UV), or DNA replication stalling, thereby acting as
CC a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-
CC Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of
CC DNA damage, involved in the regulation of DNA damage response
CC mechanism. Required for the control of telomere length and genome
CC stability. {ECO:0000256|ARBA:ARBA00025079}.
CC -!- SUBUNIT: Associates with DNA double-strand breaks.
CC {ECO:0000256|ARBA:ARBA00011370}.
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DR EMBL; DS028094; KMP03585.1; -; Genomic_DNA.
DR STRING; 404692.A0A0J6Y763; -.
DR Proteomes; UP000054565; Unassembled WGS sequence.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR CDD; cd05163; PIKK_TRRAP; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR046807; Tra1_central.
DR InterPro; IPR046805; Tra1_ring.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF1; TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF20175; Tra1_central; 1.
DR Pfam; PF20206; Tra1_ring; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853}.
FT DOMAIN 2634..3177
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 3425..3766
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3763..3795
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 157..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1996..2026
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3185..3251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3196..3229
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3795 AA; 434023 MW; 3F9B9D5E082A3C08 CRC64;
MERNIDIYAA KLADPAIESK FKTNVAVELR DSLEQLCSPP SYATFLTKLW PVFKKILKGE
PVFVSMSWEQ KLRNCILEII HRLPLDLPDV QPYAGDMVDL LMELVRVENE ENAVLCMKTI
MDLERRQVGA TQSRVQPFLE LIRDMFEGMS QVVKDTFDTP VQGSTPGMLP STPGGPQNFQ
SPRPSSPATS VSDLAPDQQG NQQLLRGMQS FKVLSECPII VVSIFQVHRA LAPQHVKVFV
PLIKGILLLQ AKPQEKAHVE AAAQGRIFTG ICKEIKNRAA FGEFITAQVK TMSFLAYLLR
QYSSHLQDFL PSLPGVVVRL LQDCPREKSS ARKELLVAIR HIINFNYRKI FLMKLDELLD
ERTLIGDGLT VYEAQRPLAY SMLADLIHHV RESLNRDQIR RTLAVYTKNL HDDIPGTSFQ
AMSAKLLLNM AERIARLEDK REARYFLIAI LDAIGDKFAA MNREFKNAIK ASKQAKENPD
GIENYLGDQH PPDWDEIDIF TATPIKTSNP RDRNADPVSD NKFLFRTLVN GLKNLFYQLR
TCNPDNVKVD PSNVLVNWTE ISYGYNAEEV RVIKKLFHEG AAVFRYYGVD EPEPELQYSS
PLEFITSQYM QQMSKEEKEL LESFGTVFHC VDPATFHEVF HSEIPYLHDL MFEHSALLHL
PQFFLASEAT SPAFAGMALQ YLMSRIHEVG SADMKKSRIL LRMFKLSFMA VTLFSAQNEQ
VLHPHVTKIV TKCIELSVTA EEPMNYFLLL RSLFRSIGGG RFELLYKELL PLLEMLLETF
NNLLLGARKI QERDLYVELT LTVPARLSHL LPHLSHLMRP LVVALRAGSD LVGQGLRTLE
LCVDNLTADY LDPIMAPIMD ELMTALWDHL RPNPYSHFHA HTTMRILGKL GGRNRKFLNH
PPDLTFQQYA DDTPSMDIKL IGSTKDRAFP LDIGIDLALG KLLKVPRSPA AKASDSFYKQ
QAYRMLSSQL KLYIGFENLP EDFAAYLRLQ ANDIIDAKFA AGIDILEKPE RQYSIPKKLV
QEETLKKLLK ACMYATTIPE LKQSASQFLA DVCRHFTIIE VGRALTQARH SRRPFNVSMG
EGPLYLDTRV LADSVVECYS SDNPAVRDAA KQAMFTVRDT AVIIFGSPAK IGKLPFFPHL
ARSFCHACHD EEWFMKAGGS LGIHLFVTDL DLGDQWLVER QAEFVRALMY VIKDTPSDFP
ASTRTRAQEA LDLVLHRCTK GLTKDELKND KSRLFGLCGF LVHELSHMNK HVREAARNAF
KTIGRTVGAE VHELLYPVKD RLLLPIFNKP LRALPFPTQI GFIEAITFCL GLHRDIVTFN
DQLNRLLMES LALADVDDES LASKPHEIKT AEQIVNLRVS CLHLLSMAMS FPDFASGPQN
SSRARIIAVF FKSLYSKSTE IIEAANSGLR DVLTQTNKLG KDLLQNGLRP ILMNLQDPKR
LSVAGLDGLA RLLTLLTNYF KIEIGARLME HMKVIADDAV LEKVSFGLIE QSHPMKIVAA
IFNIFHLLPP AATSFMENLV TRVLWLEDKL RRTANSPFRK PLIKYLNRYP KESWAFFQVR
FHDERFGRFF GQILAEPESL PLRSVVVADA NTFMTIAFGH TESPARNTAA INGIYAVHSI
CSHESTRGWL NTTPDLKRHL LNAGRDLESK LRGDKLPVNE RLRVEQADDQ LLEIFTVYLS
QNLYDLDFLF DLIDKLSAGE LKSTLAMPKF LYEHIISSDS IDYRKSIIMR CLDLYGQRNS
SQKLKTYAFR NLVNPILAMD VQRTWGSTNT GPKLMDKNMT ELIHNRLWKP QLGDISDESG
QAGVDHSRMA LLQLSALLIK YHHITVQESR KDIIKFAWSY IRLEDIINKY GAYVLISYFI
AHYETPSKIV VQIYVALLRA HQNEGKALVT QALEILAPVL PKRISSAGDA RYPLWARWPR
RILAEETANL QQVMSILQFL VRQPDLFYES REYFVPLIVP SLVKIAGPPN PSNESKKLAL
NLIGLIWTWE KRRVTDQVSG SPNPRKRKLE ETRASPPGPP GPLAMRERPD YMIPLDLRTA
LIKYLVTFIC GLPERFPVPA SKLRERNSVK VQPFVLYGDM IKRAVQLLRD LLSTEFWTDL
DIDLYQKVTE PILSGEKVAE KPDEKHITGM VNALQVLRVL LAAKPDEWVA SRVSAVQILF
EKSLRMDNPE IQDCLHGIED EMDISPKLPP PVKRVLDSLP QEQPADDEAM DVDDAPTEFA
TYLSTIATES LSANNYISAI NILWTLSKSR PAEMDQHIPH VMKVLSQKLA KDHVAVYASN
HGSAATRNGS QEQTAPDQQE FELGVGLILK TIDLIAVRMS HLGEQRRPFL SVLAQLVERS
HNIRLCSKVL GMVESWIFHS TESWPTLKEK TAVLHKMLLF EARPDQTMSK KFLELVIRIY
EDPKITRTEL TVRLEHAFLI GTRAQDVEMR SRFMTIFDRS LTRSASRRLS YVLTSQNWDT
LADSFWLTQA SQLVMGSIDM TTPAKLHPED FTLPPASFLF GHCEKDPSKA NVVVDNNLES
LISEHRTFYL DIADVKARDI LEPLSQLQHA NPKVAYKVWV TLFTICWSAL SREERIDLEK
GIVTLLTKEY HQRQLDDRPN VVQALLEGVI RAKPRFKIPP HVLKFLSRTY DAWYTAAVAL
EQSAISPIID TPTARESNLD ALVEIYSGLQ EDDMFYGTWR RRCKFVETNS ALSYEQQGMW
DKAQQLYESA QIKARTGAVP FSQGEYYLWE DHWVICAQKL QQWEILGDFA KHENFNDLLL
ESIWRSLDSW QGDANREQIE TLIKGVSDAP TPRRTFFQAF MSLLKFHAKQ ENPQEFHNTC
DEAIQLSIRK WHQLPKRITN AHIPILQIFQ QLVELHDASV ICSSLNQTNE RNLDTKSAEL
KLLLGTWRDR LPNVWDDINA WQDLVTWRQH IFQLINQTYL SLLPPQTNNV ASNSYAYRGY
HETAWIINRF AHVARKHQMP EVCINQLSRI YTLPNIEIQE AFLKLREQAK CHYQNPKELN
SGLDVINNTN LNYFGAQQKA EFFTLKGMFL AKLSHVNEAN DAFGVALYYD LRLPKAWAEW
GQYSDQRFKA DPSDMELGSN AMSCYLEAAG LYKSHKSRKL LSRILWLLSQ DNDEGKIATA
FENFKGDTPV WYWITFIPQL LTSLSHREAR LCKAVLGKIA KLYPQSLFFL LRTCREDLLG
IKKSQDQKQE KINRLKQQQR SPQIKTENKP GSQMSDAATN PSAGVGSPRP PQANPSAPQM
SSTPDVAQKE KQPWEYAEDI MAGLKTAFPL LALSMETMVD QIHKNFKCPP DEDAYRLIVA
LLNDGLAYVG RMPSSYAQDF KLPHSTEANI TRFAETILPA HIRKSFEADF VIKKPTMYEY
IHKLRRWRDK FEEKLDRRPH FHFLEAYSPH LSEFKFQKFD EVEVPGQYLE HKDKNQDFVR
IDRFLPNVDL VRGIGVCHRR LKIRGHDGSL HAFAVQHPAA RHCRREERML QLFRIFNCVL
RKRKESRRRN IYFHLPLMVP LAPHIRLVQD DSSYISLQGI YEDHCRQTGM NKDEPMLYTM
EKMRALAENK INVSRPLHGI REVTSFTNFQ QRAPDHSVIL RTEIFSAIQQ KWVPNTVLLD
FIRQTYPQYA DFWLFRRQFS YQYAAIAFMT YVMHMGNRYP SKIHISRRTG DIWSSELIPA
MNNAKALFYN PEHVPFRLTP NIQTLMGPLA TEGIFACAIM AIARCLTEPR LELEQQLSIF
VRDELLIWAA AQQRVLPQMK DLVQSNIDFI VNRAISLASP PEGNLPANQS AIDLISKAVN
PQSLAQCEAL WMPYM
//
