ID   A0A0J6YAI8_COCIT        Unreviewed;      1157 AA.
AC   A0A0J6YAI8;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   SubName: Full=DUF726 family protein {ECO:0000313|EMBL:KMP04775.1};
GN   ORFNames=CIRG_04456 {ECO:0000313|EMBL:KMP04775.1};
OS   Coccidioides immitis RMSCC 2394.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=404692 {ECO:0000313|EMBL:KMP04775.1, ECO:0000313|Proteomes:UP000054565};
RN   [1] {ECO:0000313|Proteomes:UP000054565}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RMSCC 2394 {ECO:0000313|Proteomes:UP000054565};
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- SIMILARITY: Belongs to the TMCO4 family.
CC       {ECO:0000256|ARBA:ARBA00009824}.
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DR   EMBL; DS028095; KMP04775.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0J6YAI8; -.
DR   Proteomes; UP000054565; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR007941; DUF726.
DR   InterPro; IPR029024; TerB-like.
DR   PANTHER; PTHR17920:SF24; LIPASE MIL1-RELATED; 1.
DR   PANTHER; PTHR17920; TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4; 1.
DR   Pfam; PF05277; DUF726; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF158682; TerB-like; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        555..580
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          1..218
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          405..465
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          950..969
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1005..1053
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1085..1157
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..27
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        54..81
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        85..128
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        166..183
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        203..218
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        416..450
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1085..1125
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1157 AA;  126603 MW;  E96FB62A440D0753 CRC64;
     MTSDVTGSHE PELSMPTHQN SVLPTEVSAP QPVADIYNGR GEEYRAPGGP PRQIRKKAPE
     KPDEIPQKPR VELDDFGLPI RKARPSPDSN SQPAIATTGK STGSTDNLPL RSKTEDSLAR
     QNLTRSVSAP VRDIDRSKKN PEPDTIINTD QQTKEIADRT LKKSAVDTSE QSQPNQEPSE
     IEKLGGQSDT LAAAPAVSEW SHQRLTTKDE STDSEDDERW QAMPALGSFD VYDDYGRLVA
     RGSKEEDEEA VYQGLGGAGK GYTRVQIDED AQSATSLDEE TKYLFPEPQT NALGIEDDIR
     DPMSQLQATK TLLTEGQRIA YVGVTRLIIF QMVKDLEGIQ STKSARKYLA DAADATAKWG
     QQMMIRLYGH MEIDAAEQVM IEQLAEHGVQ PVDLVPPLMQ NSRVKNPAAD CSAAKDASDS
     ASSKADRPAS SVSGTSETPS TSTSPPPYSE HQNDDLPEVR TPSQLPSSKK LDIDLRWTVL
     CDLFLVLIAD STYDARSRRL LERVAETMDI SWMQICRFEK RVVDALEMQE ERNKETWDEA
     EHMEKRRKEA LKRRYMIMGL ATVGGGLVIG LSAGLLAPVI GAGLAAGFTT IGVSGTGAFL
     GGVGGTALIT SGATLTGSTI GIRASNRRTG AVKTFEYRPL HNNKRLNLIV TAAGWMTGKV
     DDVRLPYSTV DPVMGDIYSI LWEPEMLQSM GATINILATE ALTQGLQQVL GSTILTALMA
     SLQLPIVLTK LSYLIDNPWN VSLARANASG LILADSLIDR NLGNRPVTLL GFSLGSRLIF
     SCLKELANKR AYGIVQNVYL FGSPVVANKD EYLKARSVVS GRFVNGYASN DWILGYLFRA
     TSGGIMRVAG LAPVEGIPGI ENFDATKFVN GHMAYRAAMP RLLREVGWEV ESDEFTEIED
     PDPDSHQERQ RELIREIQEA RKQAEEKPDK KKFGFFKRGK LAEKKGWETY DVDQGDRSPT
     NSCDGNADPG GTVLFDIDAI RAELASEQIQ VKQLESTLPP MKLHLNPPSP VASPSFHGQK
     KAPPLSTELE EAAIETHTAS DSPSEPADAR LQDFKPLPDL PSDGNPFNES WRQEEIQMTF
     DTAYHQTPST TSPSLAESGN HELGPVSSNL TPLHSVTQSP TETHNDPPRL AHFDKSGLNH
     NAWATDDDDS SIKLSFA
//