ID A0A0J6YB74_COCIT Unreviewed; 475 AA.
AC A0A0J6YB74;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Delta(12) fatty acid desaturase {ECO:0000313|EMBL:KMP04033.1};
GN ORFNames=CIRG_03724 {ECO:0000313|EMBL:KMP04033.1};
OS Coccidioides immitis RMSCC 2394.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=404692 {ECO:0000313|EMBL:KMP04033.1, ECO:0000313|Proteomes:UP000054565};
RN [1] {ECO:0000313|Proteomes:UP000054565}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RMSCC 2394 {ECO:0000313|Proteomes:UP000054565};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
CC -!- PATHWAY: Lipid metabolism. {ECO:0000256|ARBA:ARBA00005189}.
CC -!- SIMILARITY: Belongs to the fatty acid desaturase type 1 family.
CC {ECO:0000256|ARBA:ARBA00009295}.
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DR EMBL; DS028094; KMP04033.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0J6YB74; -.
DR STRING; 404692.A0A0J6YB74; -.
DR Proteomes; UP000054565; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:UniProt.
DR CDD; cd03507; Delta12-FADS-like; 1.
DR InterPro; IPR005804; FA_desaturase_dom.
DR InterPro; IPR012171; Fatty_acid_desaturase.
DR PANTHER; PTHR32100:SF35; OMEGA-3 FATTY ACID DESATURASE FAT-1; 1.
DR PANTHER; PTHR32100; OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC; 1.
DR Pfam; PF00487; FA_desaturase; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 292..310
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 322..340
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 129..415
FT /note="Fatty acid desaturase"
FT /evidence="ECO:0000259|Pfam:PF00487"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..44
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 475 AA; 53489 MW; 96B06A483E9E21C5 CRC64;
MSSSALPKRV ALHRQMTESS SVTSSVTPSP MESPRHSPST TSLSSLASEA LAEGSSKLLD
TYGNEFEIPN FTIKEIRDAI PAHCFKRDGI RGLLYVFRDL ACLGVTFYAF HNYVTPENIP
STPIRAGLWA LYTFVQGLFG TGIWVLAHEC GHQSFSPSKV LNDTVGWILH SSLLVPYFSW
KISHGKHHKA TGNLERDMVF VPKTREQYAS RMGYFVHQLN EVMEETPIQA ATNLILQQLF
GWPMYLLSNV TGHNNHECQR EGRGKGKKNG MFTGVNHFNP SSPLYEAKDA KLIVLSDIGL
LIMGSILYAL GQRFGWTNLL VWYFIPYLWV NHWLVAITYL QHTDPSLPHY HSSVWNFARG
AAATIDREFG FIGRQLFHGI IETHVLHHYV STIPFYNADE ATEAIKKVMG KHYRSDTKGG
SLGFIRALWR STRMCQWVEP SEGAQGEGKD VLFFRNRNGL GPRPLVVEPE EGKAK
//
