ID A0A0J6YB91_COCIT Unreviewed; 812 AA.
AC A0A0J6YB91;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Carnitine O-palmitoyltransferase 2 {ECO:0000313|EMBL:KMP04063.1};
GN ORFNames=CIRG_03754 {ECO:0000313|EMBL:KMP04063.1};
OS Coccidioides immitis RMSCC 2394.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=404692 {ECO:0000313|EMBL:KMP04063.1, ECO:0000313|Proteomes:UP000054565};
RN [1] {ECO:0000313|Proteomes:UP000054565}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RMSCC 2394 {ECO:0000313|Proteomes:UP000054565};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
CC -!- SIMILARITY: Belongs to the carnitine/choline acetyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005232}.
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DR EMBL; DS028094; KMP04063.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0J6YB91; -.
DR STRING; 404692.A0A0J6YB91; -.
DR Proteomes; UP000054565; Unassembled WGS sequence.
DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR Gene3D; 1.10.275.20; Choline/Carnitine o-acyltransferase; 1.
DR Gene3D; 3.30.559.70; Choline/Carnitine o-acyltransferase, domain 2; 1.
DR InterPro; IPR000542; Carn_acyl_trans.
DR InterPro; IPR042572; Carn_acyl_trans_N.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR039551; Cho/carn_acyl_trans.
DR InterPro; IPR042231; Cho/carn_acyl_trans_2.
DR PANTHER; PTHR22589; CARNITINE O-ACYLTRANSFERASE; 1.
DR PANTHER; PTHR22589:SF29; MITOCHONDRIAL CARNITINE O-ACETYLTRANSFERASE-RELATED; 1.
DR Pfam; PF00755; Carn_acyltransf; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR PROSITE; PS00440; ACYLTRANSF_C_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:KMP04063.1};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 68..698
FT /note="Choline/carnitine acyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00755"
FT REGION 1..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 409..430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 588..629
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 712..739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..62
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 588..624
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 374
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600542-1"
SQ SEQUENCE 812 AA; 89859 MW; 1AFA53B0C374182F CRC64;
MSHPPSPVRF FTMPKPLGDA LEGPSRPQVS SSTGAIPPSP KPSGEGNDGS VTNQTRVTFS
KQDSLPRLPI PDLESTCRRY LESLAPLQSP SEHEETKASV QDFLKSDGPD LQEKLKLYAS
SKTSYIEEFW YDSYLNYDNP VVLNLNPFFL LEDDPTPARN HQVTRAASLV VSALSFVRAV
RREELTPDTV RGKPLCMFQY SRLFGTARVP TSNGCVIGQD SASKHLVIMC RGQFYWFDVL
DENDDLIMSE KDISLNLSAI IEDAEQTPIQ EAAKGAIGVL STENRKVWSG LRDILNRQSG
SNNADCLNIV DTALFVLCLD DAEPSNIAEI CGNMLCGTSE VVKGVQIGTC TNRWYDKLQI
IVCQNGSAGI NFEHTGVDGH TVLRFASDVF TDTILRFAKT INGQAPSIWA STGPTPAKRK
PNGYRHASTT PRKLEWDMGP ELSTAVRFAE SHIADLLHQH EFEALDFRAY GKNFITSMGF
SPDAFVQMAF QAAYYGLYGR IENTYEPAMT KTYLHGRTEA IRTVSSESVD FVQTFWGDNP
IAEKVNALRK ATQKHTAITR ECSQGQGHDR HLYALYSLWQ RSLDERQPSI CSGGSSPDGY
SSPIEGGNSD DSHSSVSSRS GRSKMNHLPE IFKDPGWEKI NNTILSTSNC GNPSLRHFGF
GPTSGDGFGI GYIIKDDSIS ICASSKHRQT SRFMQTLESY LLEIRKLLRA ASRPSEEPRA
AAPPNAAQER LGTGTRTPRR GRLIHTDAAA REVDTPMTES GCFDDDGMGG YGFFDAGMLL
QALQELQEVR ERGRDKKSRR RLVGKTLKLN DY
//
