ID   A0A0J6YBJ8_COCIT        Unreviewed;      1346 AA.
AC   A0A0J6YBJ8;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   28-JUN-2023, entry version 29.
DE   SubName: Full=C2 domain containing protein {ECO:0000313|EMBL:KMP06116.1};
GN   ORFNames=CIRG_05797 {ECO:0000313|EMBL:KMP06116.1};
OS   Coccidioides immitis RMSCC 2394.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=404692 {ECO:0000313|EMBL:KMP06116.1, ECO:0000313|Proteomes:UP000054565};
RN   [1] {ECO:0000313|Proteomes:UP000054565}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RMSCC 2394 {ECO:0000313|Proteomes:UP000054565};
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
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DR   EMBL; DS028096; KMP06116.1; -; Genomic_DNA.
DR   STRING; 404692.A0A0J6YBJ8; -.
DR   Proteomes; UP000054565; Unassembled WGS sequence.
DR   CDD; cd04043; C2_Munc13_fungal; 1.
DR   Gene3D; 1.10.357.50; -; 1.
DR   Gene3D; 1.20.58.1100; -; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 1.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR010439; MUN_dom.
DR   InterPro; IPR014770; Munc13_1.
DR   InterPro; IPR014772; Munc13_dom-2.
DR   PANTHER; PTHR47263; ADENYLATE CYCLASE ACTIVATION PROTEIN GIT1; 1.
DR   PANTHER; PTHR47263:SF1; C2 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G02350); 1.
DR   Pfam; PF00168; C2; 1.
DR   Pfam; PF06292; MUN; 1.
DR   SMART; SM00239; C2; 1.
DR   SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR   PROSITE; PS50004; C2; 1.
DR   PROSITE; PS51258; MHD1; 1.
DR   PROSITE; PS51259; MHD2; 1.
PE   4: Predicted;
FT   DOMAIN          684..810
FT                   /note="MHD1"
FT                   /evidence="ECO:0000259|PROSITE:PS51258"
FT   DOMAIN          891..1008
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   DOMAIN          1102..1224
FT                   /note="MHD2"
FT                   /evidence="ECO:0000259|PROSITE:PS51259"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..27
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1346 AA;  155022 MW;  75604B5E7BE71C28 CRC64;
     MSTSSTNSYR ISRRLNSHTS QDLRSHSRNI SVARRRPISH NDAYTYALRV AFLSYLLQPR
     LRRPQSLPPK PNPNRSSTTF HDLMKDFSLV RDSKSTRFPH GFIAELEKRL TGVLIGRERR
     KEYQDALVKR TFAVFLNALK EQSFKKRMEK DRRVEDLVLI FFSNATKELS KGKAPEDISW
     KLMVDRHVAL FVRLITLILK DHDWLREKPE LAARLATLET KLLAHDQDLA QASQPDRVGT
     PTEPVPLSYD VKDMHLVQVV AKIFGLRESQ VQSDINKNKD SWTAKEALQD LKKYQTHLNL
     HTGKTLSRTD FEHEEAYESW KKAEAPHLSQ MVLAIVQSNI ELAKSTPVAG LPQFNDPQSE
     TTPTSDAYSL SQPVDISALS ISDAAEEPQL DTGDLYTFIP PDPRSYYRFI LTQAITHDLN
     DRLLEPSEAT SEIPSMKLLS KQSTELLNEL ALRWRIPTFS RAALFLEVFG SKFVDQEVDL
     DTLDSAFIFV KEPPPEKNKR ASFVAPVFYD RNKWTRADIC TMQRILASLH NALLRQLYET
     LMHCYDNKIP PLGPVLYVLE NHVESDPNFL SSPEDQEQFQ KYAHDGLVEK AKEVYQENLN
     KEVPPEQEAW EFYHVVQLSK AIMKLCQRIQ KRYKKNPEIM GVNPLTALVN CVLPMFAEDA
     HDMVRRIIQQ AKNNDVEIEV QEGFDLYKEL SDMRRVYAEV LPGDPFPMPI EELLADFVWR
     WVQLTDEKMV GWVEQAIKQD NFMVRTELPE DIPTEEQRHS VSVVDIFRSF NQVVNQIVEL
     NWDDDVGYAK FMTSVSKSIG NALSRYCEIL EQSFIKEMDR PTPEQEAAAR QTKQEKWMQM
     AKEAWSSKEK VEPFHFFRES FVKLNNIEYA LQQLDKLEKD INVDACAEVL SKNAPPLSKK
     QRKATNYVFT VKIVEAEDLK GCDMDGLSDP YVVLTDEYQK RIYKTRIIYD NLNPRWDDSV
     DIMTRTPLNI IATLWDWDAV GDHDYVGRTS LKLDPAHFSD FAPKEYWLDL DTQGRLLLRV
     SMEGERDDIQ FYFGKTFRTL KRTEREMTRK TTEKLSAYIN HCLSRRALKA LLSRGISMST
     VSSYFNRNRA PTSQAPTPVE IEGALHPLFT YFDDNFAIMN LTLTADAMRK VMARLWKEVL
     VTVEGLLVPP LSDKPSNQRP LTQQEVDIVS RWLTLLLSFF NAVDEETGEA NGVPMDILKS
     PKYHEIQTLF FFYFEPTEHL IRTSERMANA TAARQQANRN RLSVTSASFS PLAGIPSSRR
     GKSIMYKRNL GTMKKAKEEK WREAQAEPND DMILRILRMR PEAAGYLRDR SRQKERLATA
     AAADLIVKQS LMASGGGRMS GILPRG
//