ID   A0A0J6YBQ4_COCIT        Unreviewed;       446 AA.
AC   A0A0J6YBQ4;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=Sterigmatocystin 8-O-methyltransferase {ECO:0000313|EMBL:KMP05170.1};
GN   ORFNames=CIRG_04851 {ECO:0000313|EMBL:KMP05170.1};
OS   Coccidioides immitis RMSCC 2394.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=404692 {ECO:0000313|EMBL:KMP05170.1, ECO:0000313|Proteomes:UP000054565};
RN   [1] {ECO:0000313|Proteomes:UP000054565}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RMSCC 2394 {ECO:0000313|Proteomes:UP000054565};
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
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DR   EMBL; DS028095; KMP05170.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0J6YBQ4; -.
DR   STRING; 404692.A0A0J6YBQ4; -.
DR   Proteomes; UP000054565; Unassembled WGS sequence.
DR   GO; GO:0008171; F:O-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR016461; COMT-like.
DR   InterPro; IPR001077; O_MeTrfase_dom.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR43712; PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED; 1.
DR   PANTHER; PTHR43712:SF12; STERIGMATOCYSTIN 8-O-METHYLTRANSFERASE; 1.
DR   Pfam; PF00891; Methyltransf_2; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS51683; SAM_OMT_II; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW   ECO:0000313|EMBL:KMP05170.1};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000313|EMBL:KMP05170.1}.
FT   DOMAIN          241..420
FT                   /note="O-methyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF00891"
SQ   SEQUENCE   446 AA;  50391 MW;  DB4DC3DFA7E06107 CRC64;
     MADHQPTLND LAARVTELAK EFTDYLQEKN VPPPTFAADS PTSYSNLSPE SFLTRQMLSD
     TLMDMWYLVQ GPSESIFNYV HTCMPDAAAL HLLNYFDFWS SVPLDGSASY ADIAKHTSLP
     EEVVQRILAH ATTLRIFAET EPGKLSSRIQ HTSRSAALAR SSGLRALVST ILDDAGPPMM
     VMNKALQKYT CGKPTLTKNM NETSFALLHS GGLFGKYANC WEFIENDGEG ERKGWRQRNF
     VEFMRYIKEI FRLEEVVLKS YDWKAAGKAT VVDVGGSGGH DDVVLAQNYP DLTITVQDLP
     QVRPTFEANL PAALKSRVSF MEHNFFHPQP VQADIYMIKM ILHDWPDQES IQILRSLVPA
     MKPGARVIFI DYVGKREERE GPPLPRSIQQ MGTATDLRMM ALFNAKERPV DAWKDIFRAA
     DERFEITRVD ANPLAFFVVI EAVWRE
//