ID   A0A0J6YF31_COCIT        Unreviewed;       723 AA.
AC   A0A0J6YF31;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Disulfide-isomerase A6 {ECO:0000313|EMBL:KMP06295.1};
GN   ORFNames=CIRG_05976 {ECO:0000313|EMBL:KMP06295.1};
OS   Coccidioides immitis RMSCC 2394.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=404692 {ECO:0000313|EMBL:KMP06295.1, ECO:0000313|Proteomes:UP000054565};
RN   [1] {ECO:0000313|Proteomes:UP000054565}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RMSCC 2394 {ECO:0000313|Proteomes:UP000054565};
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004389}; Single-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004389}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004167}.
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DR   EMBL; DS028096; KMP06295.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0J6YF31; -.
DR   STRING; 404692.A0A0J6YF31; -.
DR   Proteomes; UP000054565; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR   CDD; cd02961; PDI_a_family; 2.
DR   Gene3D; 3.40.30.10; Glutaredoxin; 2.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   InterPro; IPR017937; Thioredoxin_CS.
DR   InterPro; IPR013766; Thioredoxin_domain.
DR   PANTHER; PTHR46426; PROTEIN DISULFIDE-ISOMERASE TMX3; 1.
DR   PANTHER; PTHR46426:SF1; PROTEIN DISULFIDE-ISOMERASE TMX3; 1.
DR   Pfam; PF00085; Thioredoxin; 3.
DR   SUPFAM; SSF52833; Thioredoxin-like; 3.
DR   PROSITE; PS00194; THIOREDOXIN_1; 1.
DR   PROSITE; PS51352; THIOREDOXIN_2; 2.
PE   4: Predicted;
KW   Isomerase {ECO:0000313|EMBL:KMP06295.1};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..723
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5005284920"
FT   TRANSMEM        658..679
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          10..180
FT                   /note="Thioredoxin"
FT                   /evidence="ECO:0000259|PROSITE:PS51352"
FT   DOMAIN          237..465
FT                   /note="Thioredoxin"
FT                   /evidence="ECO:0000259|PROSITE:PS51352"
FT   REGION          185..257
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   723 AA;  81695 MW;  E2A6D4019F0241B1 CRC64;
     MKASFLAFSL LAAVFQPVFA ASHGQEKRAD AKLENDASDR TTIFNDVRVP PMKEVNAAGF
     DETIKDGYWF VKFYSPYCHF CKAVRPAWQT LYEFYYTSNP LKSSTSKQVP NPESSLNSFQ
     GYYDFHFAEM DCVVNGDKCQ ELEVKEWPTF ALYHDGKLVE KYDGGRNMEG LSRFVEKWLE
     SIKPGSRPRG EMKLPEPGAK IAPEQPKDQE GAIIGEPDIN AGSSTPAASQ KSDDSVKPAA
     PALPERKQPA PNPQGMSVPL TAESFQKLVT TTRDPWFVKF YAPWCVHCQA LAPIWSQMAK
     DLKGKLNIGE VNCEVEKRLC KDARVNVYPT MYFFRGGERV EYEGLRGLGD LVNYARKAVD
     VVGSGVQYVD ATAFKKMEET EEVIFLYFFD HATTSEDFAA LDRLTLSLVG RARLVKTNST
     ILAERFKIST WPRLLVSRDG RPSYYTALAP KDMRDFRQVL AWMQKVWLPI VPEMTASNAK
     EIMERKYVVL GILNRQRSDE FIQDKRELKN AALEWMEKQT KLFQLERQEL RDAKELRIEE
     ADDRDDQRAL RAAKNTRITI KEDDKKQVAF AWVDGIFWDR WIRTTYGIDV RNGERVIIND
     EENRRYWDTT PNGGFIVPSR TSILETITHV VSNPSKLKSK STVGTFEGLF FSIRTFTFAH
     PIITFLLFVA VLFVSSFIAR GKLRRGRSAG GLLGSVGGSS GGFFHLDGKE GLLGGGSGGG
     KVD
//