ID A0A0J6YGS8_COCIT Unreviewed; 606 AA.
AC A0A0J6YGS8;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=D-lactate dehydrogenase {ECO:0000313|EMBL:KMP06093.1};
GN ORFNames=CIRG_05774 {ECO:0000313|EMBL:KMP06093.1};
OS Coccidioides immitis RMSCC 2394.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=404692 {ECO:0000313|EMBL:KMP06093.1, ECO:0000313|Proteomes:UP000054565};
RN [1] {ECO:0000313|Proteomes:UP000054565}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RMSCC 2394 {ECO:0000313|Proteomes:UP000054565};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
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DR EMBL; DS028096; KMP06093.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0J6YGS8; -.
DR STRING; 404692.A0A0J6YGS8; -.
DR Proteomes; UP000054565; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR Gene3D; 3.30.465.10; -; 1.
DR Gene3D; 3.30.70.2740; -; 1.
DR InterPro; IPR004113; FAD-bd_oxidored_4_C.
DR InterPro; IPR016166; FAD-bd_PCMH.
DR InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR InterPro; IPR016164; FAD-linked_Oxase-like_C.
DR InterPro; IPR006094; Oxid_FAD_bind_N.
DR InterPro; IPR016171; Vanillyl_alc_oxidase_C-sub2.
DR PANTHER; PTHR11748; D-LACTATE DEHYDROGENASE; 1.
DR PANTHER; PTHR11748:SF116; D-LACTATE DEHYDROGENASE (CYTOCHROME) (AFU_ORTHOLOGUE AFUA_7G02560); 1.
DR Pfam; PF02913; FAD-oxidase_C; 1.
DR Pfam; PF01565; FAD_binding_4; 1.
DR SUPFAM; SSF56176; FAD-binding/transporter-associated domain-like; 1.
DR SUPFAM; SSF55103; FAD-linked oxidases, C-terminal domain; 1.
DR PROSITE; PS51387; FAD_PCMH; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 84..105
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 173..350
FT /note="FAD-binding PCMH-type"
FT /evidence="ECO:0000259|PROSITE:PS51387"
SQ SEQUENCE 606 AA; 66727 MW; 4938571FE2EFBCD6 CRC64;
MFSSREVASK AARAAKRAQR ITTTVYNSTP KNRAHAKRSF GTTCARAEER PTFKGQLYES
TQQRIQRERA ELERYARMQK DSSALRNTAI TFTVLVTALG CYYLGSLRPA ALPESSTTPL
YSAPKPHHDT SPGNLQAAWS DFIHIVGKEN VSTDKVDLDA HAGSDWSSYT AKESERPFLV
VFPSTTEEVS RIMKVCHDRR IPVTAFSGGT SLEGHFSPTR GGVCVDFARM GNIIALHEDD
LDVVVQPAVG WEDLNEELAK RGLFFPPDPG PGAQIGGMVG TGCSGTNAYR YGTMREWVLS
LTVVLADGTI IKTRQRPRKS SAGYDLTKLF IGSEGTLGLV TEATLKVTPK PKSESVAVAA
FPSIHCAAEC VARVVGEGIQ VAGVEILDDV QMKCINDSQT TRRTWKEAPT IFFKFTGTPA
GVKEQIKIVQ KIAKDTMGQS FEFAQGRDEM QELWSARKEA LWSVMAMKRD QNDHVWTTDV
AVPISRLPDI IEQTKEDITK KGLLGGICGH VGDGNFHAIL LFNDSERNVA EGVVHRMVKR
AVEMEGTVTG EHGVGLIKRD YLPHELGDSA VDTMRKIKQA LDPLCLLNCD KVVRMEPPKQ
GEIKKW
//
