ID A0A0J6YM18_COCIT Unreviewed; 465 AA.
AC A0A0J6YM18;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Probable kinetochore protein NUF2 {ECO:0000256|ARBA:ARBA00017594};
GN ORFNames=CIRG_08411 {ECO:0000313|EMBL:KMP08730.1};
OS Coccidioides immitis RMSCC 2394.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=404692 {ECO:0000313|EMBL:KMP08730.1, ECO:0000313|Proteomes:UP000054565};
RN [1] {ECO:0000313|Proteomes:UP000054565}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RMSCC 2394 {ECO:0000313|Proteomes:UP000054565};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
CC -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC NDC80 complex, which is required for chromosome segregation and spindle
CC checkpoint activity. {ECO:0000256|ARBA:ARBA00002772}.
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC {ECO:0000256|ARBA:ARBA00004629}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the NUF2 family.
CC {ECO:0000256|ARBA:ARBA00005498}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DS028098; KMP08730.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0J6YM18; -.
DR STRING; 404692.A0A0J6YM18; -.
DR Proteomes; UP000054565; Unassembled WGS sequence.
DR GO; GO:0031262; C:Ndc80 complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR Gene3D; 1.10.418.60; Ncd80 complex, Nuf2 subunit; 1.
DR InterPro; IPR005549; Kinetochore_Nuf2_N.
DR InterPro; IPR041112; Nuf2_DHR10-like.
DR InterPro; IPR038275; Nuf2_N_sf.
DR PANTHER; PTHR21650:SF2; KINETOCHORE PROTEIN NUF2; 1.
DR PANTHER; PTHR21650; MEMBRALIN/KINETOCHORE PROTEIN NUF2; 1.
DR Pfam; PF03800; Nuf2; 1.
DR Pfam; PF18595; Nuf2_DHR10-like; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Centromere {ECO:0000256|ARBA:ARBA00023328};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Kinetochore {ECO:0000256|ARBA:ARBA00022838};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT DOMAIN 31..171
FT /note="Kinetochore protein Nuf2 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF03800"
FT DOMAIN 283..398
FT /note="Nuf2 DHR10-like"
FT /evidence="ECO:0000259|Pfam:PF18595"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 170..232
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 279..453
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 465 AA; 54913 MW; 26CAC7024DA74C4E CRC64;
MAYNSRMSQQ FHHGGQQQHN RNRKPKEDDT DAFLRLPDKV IAGCINDIGI PFTVADLLKP
NPQQIQIIFE WFAELFMNTT RETVEPAMLA AAEDICGDHA GIIPPDSRNL MGFFVSLRKL
MIQCGVQDFT FTDLTKPTYD RMAKIFSYLI NFVRFRESQT AVIDEHFNKS ENTKSRIESL
YAENQELEQR LEEMHTQQRE MEGVVKEKVR RNDELKARLL ELRRNQERVA ETFERVKGEK
TRTQTLLEEK TEKLLKTRQE SEKLRPYVSQ SPAILQAALT ELSENLTRDK IQIDNMERRM
RALQMSMDTF SVISNDVQSC IKVLEDISAE LQKEEEEDAR AIRNKDALAE RGNTVREVAQ
TERMLQRQLG RWHERTEALR KSAREKAEQA QARMEELHNI QKQLREERAE KQRDMERRRI
RIEQTEKKMV DLKENIENEI HRAHDEYLKM ESHIKLYITE MEKCL
//
