ID   A0A0J7B8Q6_COCIT        Unreviewed;       693 AA.
AC   A0A0J7B8Q6;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Developmental regulator flbA {ECO:0000313|EMBL:KMP06352.1};
GN   ORFNames=CIRG_06033 {ECO:0000313|EMBL:KMP06352.1};
OS   Coccidioides immitis RMSCC 2394.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=404692 {ECO:0000313|EMBL:KMP06352.1, ECO:0000313|Proteomes:UP000054565};
RN   [1] {ECO:0000313|Proteomes:UP000054565}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RMSCC 2394 {ECO:0000313|Proteomes:UP000054565};
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
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DR   EMBL; DS028096; KMP06352.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0J7B8Q6; -.
DR   STRING; 404692.A0A0J7B8Q6; -.
DR   Proteomes; UP000054565; Unassembled WGS sequence.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   CDD; cd04450; DEP_RGS7-like; 1.
DR   CDD; cd08708; RGS_FLBA; 1.
DR   Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR   InterPro; IPR000591; DEP_dom.
DR   InterPro; IPR016137; RGS.
DR   InterPro; IPR036305; RGS_sf.
DR   InterPro; IPR044926; RGS_subdomain_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR10845; REGULATOR OF G PROTEIN SIGNALING; 1.
DR   PANTHER; PTHR10845:SF192; RGS DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR   Pfam; PF00610; DEP; 1.
DR   Pfam; PF00615; RGS; 1.
DR   PRINTS; PR01301; RGSPROTEIN.
DR   SMART; SM00049; DEP; 2.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR   PROSITE; PS50186; DEP; 1.
DR   PROSITE; PS50132; RGS; 1.
PE   4: Predicted;
KW   Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700}.
FT   DOMAIN          401..487
FT                   /note="DEP"
FT                   /evidence="ECO:0000259|PROSITE:PS50186"
FT   DOMAIN          519..661
FT                   /note="RGS"
FT                   /evidence="ECO:0000259|PROSITE:PS50132"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          72..199
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          668..693
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        72..119
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        150..199
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        668..683
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   693 AA;  76706 MW;  08E891417B0C7340 CRC64;
     MSSRSALDKY REGSNTLPHS HRSYIPLDNS SNCTSASHHR AASISRFSRR SLAAIALEKT
     SSALNNLVSL GGSSNPPVRS APAFSGGNNL KLSPTATSPP TEYFPDINGG RSGNSNESGR
     GGVADHLGSR FPLQTESNGD PAHTGPLPDQ PASPTYSQRN HSNPSISNRR NTLQAHSADT
     SQMPSAKMHQ TSSRLLRMTS DDRPFSRDFK DLFSTLMVSL KLESHRVRFS KFDHTFMSEE
     AINNLGSLKF SQSNRMPDPK DPSRIVTTTT TTTFSMAREM ARSVCQRFVD ARFIEPVDGR
     VTAQFPLKGS LFQLTPKGIH ILHRFCQRNG ITARHVMDVL ESPRNTMQLV ILERDSQTDQ
     LSRDRATIEV IFRRFAGVDG PNLKNTVSSS DSDSVSDYAN GTTGVKMAKE RKVGDKVIQN
     SFTGKAAVDW ILDCCTASDN RETYEIAVMF VKYNLIYAIA EDKGYMLQHP GATSFQPTKH
     AIYGITEHGQ RVCGWIARDK VTPTSIDGRV VPRDSNNARL NHILQDAALR LLFREFLRDS
     LCEENLAFYL DVSTFTADYH RAERAGTFSR MDAVRETLAS AYGLYNAFLA PGSPCELNIE
     HALRNSLASR MTRAVGDDEA MIESLTEVVS LFELAQVSVF KLMSSDSVPK FVRDPRYANI
     LQEHDFDVNS SGRSYSPTPA PVPERSMSRS ARS
//