ID   A0A0J7BBB9_COCIT        Unreviewed;       483 AA.
AC   A0A0J7BBB9;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   SubName: Full=Cation diffusion facilitator 1 {ECO:0000313|EMBL:KMP07362.1};
GN   ORFNames=CIRG_07043 {ECO:0000313|EMBL:KMP07362.1};
OS   Coccidioides immitis RMSCC 2394.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=404692 {ECO:0000313|EMBL:KMP07362.1, ECO:0000313|Proteomes:UP000054565};
RN   [1] {ECO:0000313|Proteomes:UP000054565}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RMSCC 2394 {ECO:0000313|Proteomes:UP000054565};
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; DS028097; KMP07362.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0J7BBB9; -.
DR   STRING; 404692.A0A0J7BBB9; -.
DR   Proteomes; UP000054565; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0098771; P:inorganic ion homeostasis; IEA:UniProt.
DR   GO; GO:0030003; P:intracellular monoatomic cation homeostasis; IEA:UniProt.
DR   Gene3D; 1.20.1510.10; Cation efflux protein transmembrane domain; 1.
DR   Gene3D; 3.30.70.1350; Cation efflux protein, cytoplasmic domain; 1.
DR   InterPro; IPR002524; Cation_efflux.
DR   InterPro; IPR027470; Cation_efflux_CTD.
DR   InterPro; IPR036837; Cation_efflux_CTD_sf.
DR   InterPro; IPR027469; Cation_efflux_TMD_sf.
DR   NCBIfam; TIGR01297; CDF; 1.
DR   PANTHER; PTHR43840:SF12; CATION DIFFUSION FACILITATOR 1 (AFU_ORTHOLOGUE AFUA_1G14440); 1.
DR   PANTHER; PTHR43840; MITOCHONDRIAL METAL TRANSPORTER 1-RELATED; 1.
DR   Pfam; PF01545; Cation_efflux; 1.
DR   Pfam; PF16916; ZT_dimer; 1.
DR   SUPFAM; SSF160240; Cation efflux protein cytoplasmic domain-like; 1.
DR   SUPFAM; SSF161111; Cation efflux protein transmembrane domain-like; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        192..213
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        219..240
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        261..283
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        303..322
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          394..468
FT                   /note="Cation efflux protein cytoplasmic"
FT                   /evidence="ECO:0000259|Pfam:PF16916"
FT   REGION          1..154
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        54..82
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   483 AA;  54105 MW;  E99B3AADB5E4312C CRC64;
     MAFTKTSIRG RRHQFTPKHA VSSYSHTGRS MADGRRPSHA HVVPPYHLHP RTDMAAPPSP
     PRHLCDSLPP HPPPPPPPLG TSTGIEAIPY SYPAMMNNSS DEEGRPPRYT RENDPFQLSS
     KLKSDAEIDS IPANTARRRK FPKPNGTKSS AKQLQGFYRS QNANIERLLK PVDEHVRLAR
     ELNTQNQLRY RIAVYGSFAA NVVLSILQLY GAIASGSLSL FTTMADSVFD PLSNLTLLLC
     HKAVKRVDAR KFPAGKARIE TAGNICFCFL MMAVSLILIA FSIRDLVDGS EEETLRFSLP
     PVIAVSIAFA TKFLLFLYCW ALRNQYSQVR ILWEDHRNDL LINGFGILTS VGGSKLRWWI
     DPMGALILSV LISALWSKTA YSEFQLIIGV TADTEMQQLI TYISMTHSPL INAIDTVRAY
     TSGPRLLVEV DIVMDPEASL RATHDVAEEL QFKLESLPDV ERAHVHVDYE TTHKPEHFLK
     KEL
//