ID A0A0J7I6L1_9FLAO Unreviewed; 2336 AA.
AC A0A0J7I6L1;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=Erythronolide synthase {ECO:0000313|EMBL:KMQ62002.1};
GN ORFNames=ACM40_06700 {ECO:0000313|EMBL:KMQ62002.1};
OS Chryseobacterium sp. BLS98.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales; Weeksellaceae;
OC Chryseobacterium group; Chryseobacterium.
OX NCBI_TaxID=885586 {ECO:0000313|EMBL:KMQ62002.1, ECO:0000313|Proteomes:UP000036030};
RN [1] {ECO:0000313|EMBL:KMQ62002.1, ECO:0000313|Proteomes:UP000036030}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BLS98 {ECO:0000313|EMBL:KMQ62002.1,
RC ECO:0000313|Proteomes:UP000036030};
RA Pipes S.E., Miller J.R., Newman J.D.;
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KMQ62002.1}.
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DR EMBL; LFNF01000002; KMQ62002.1; -; Genomic_DNA.
DR STRING; 885586.ACM40_06700; -.
DR PATRIC; fig|885586.5.peg.1388; -.
DR OrthoDB; 9778690at2; -.
DR Proteomes; UP000036030; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0018580; F:nitronate monooxygenase activity; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd08953; KR_2_SDR_x; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.20.20.70; Aldolase class I; 2.
DR Gene3D; 3.30.70.250; Malonyl-CoA ACP transacylase, ACP-binding; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR004136; NMO.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43074; OMEGA-3 POLYUNSATURATED FATTY ACID SYNTHASE PFAB-RELATED; 1.
DR PANTHER; PTHR43074:SF1; PKS_AT DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF03060; NMO; 2.
DR Pfam; PF00550; PP-binding; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51412; Inosine monophosphate dehydrogenase (IMPDH); 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 647..1086
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1652..1738
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1764..1849
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 2336 AA; 255880 MW; 5268222C4E0B61EA CRC64;
MNAMKNLTII GLTPFEKPDV KLMQKLHGAG AFPILSLGHD LAAAQTALDQ IARTDIPSYG
IYLPNDKFIS LQIPEKVRFA ILPSGVSMNI VPDLPVIYQV TSLDEARLAE QWGAEGIIIK
GNEAGGLVGY ESTFVLFQRV IKEIQTLPVW VQGGIGLHTA AAVKSLGATG IVLDSQLALF
PESSVPQEIK DLASKLNGTE TKIIANHRVL VRPNSPALPE NVTAEELRQY FTDFDLNNSY
IPMGQDISLT IDLYEDFKSL KKMVFGFKEA MYGHLKQAKA LEVISENNIM AQKLGLRYPI
AQGPMTRVSD VPLFANAVAD AGALPFVALS LLKGEQAKAL VMETKKLAGE KTWGVGILGF
APQELREEQT SYILETKPPV VLIAGGRPAQ AKVFEKAGIT TFLHVPSPAL LDIFLKEGAT
NFIFEGRECG GHVGPLSSMV LWEKQIERIL KEEHPENISV FFAGGIHNAF STAFVSIMAA
PLAARGVKVG VLIGTAYLYT EEAVRTGAIQ EEFQVQAMQA KDTVLLETAP GHETRCLNTT
FAQHFNKEKK KLLAAGTDKK EVWEQLEKLN VGRLRIAAKG IDRQGDKLVN IPKNEQLDLG
MYMIGQVATM QNRVISLASL HQNVSIDNYK YIEEAALPEQ PVSTEKPLDV AIVGMECIFP
GAKNLEEYWR NIILGRDSVT EVPDERWNKE LYYHPDSDGP DVSHSKWGGF IPKIDFDPLA
FGIPPQSLAA IEPTQLLTLL VAKRAMEDAG YGEKHINREN ISVIIGAEGG NDLANSYSFR
GYYKQVFGEL HEEVKQAFPH TTEDSFPGIL ANVIAGRITN RLDLGGRNFT VDAACASSLA
AIDLACQELA LGKSDMVLAG GADLHNGIND YLMFSSTHAL SRKGRCATFD GDADGIALGE
GVAILVLKRY EDAVRDGDRI YSVIKGVGGS SDGKALGLTA PRKIGQVRAL ERAYSQAGIS
PASVGLVEAH GTGTVVGDKT ELSALTNLFS RSGAIPGQTH LGSVKTQIGH TKCAAGLAGL
IKASLAVYHG VKPPTLHLQQ PNAYYNAQTS PFAFYAESGL WGEKNRYAGI SAFGFGGTNF
HTVIANHPKE DDSAVLQSWP SELFVFCGET YEDAKIQLAQ IKSLLEVNGD IPLKDMAYSL
AVGSEKPIQL SIVADTAEHL MMNIELALSG IESKDTFTVN RRDGKVAFLF PGQGSQRINM
ARDLFVAFPA MRNLIDKYPE LEKVVFPSAT FDETALKQQK ETIKDTRLAQ PILGMVDLAL
AQFLKSLDIV PDMVAGHSYG ELPALCFAGV FEEEKLVDLS IQRAHAILDS VEGGDPGTMI
AVSATREQLQ PVLDKTEGCY PVNYNAPTQC VVAGSTPAIN KLMEILKQER ISAKKLEVAC
AFHSPLLAKS KGLYNEVLKD IAFQEMQIPV WSNTTAETYP AAPSEIKERL TDHLVQPVRF
VEELQAMYED GARIFIEVGP GKVLSGLTKS CLEKDQLTLY VEDSNRNKLS HLLSMLAQYL
GTGRSFSIEK LFDGRNAKLI QIDQPELYKK NPAIWRVNGQ TAHPTTGNLP ANGALPILNP
IAMNNFTNNQ PAPVAESQPA AERMLQEYLN TMKQLIQAQR DVMLSFLGQN PQVSPAPVYA
APVQATVNDR LVTIPAQPVH VEKPVAVAVK QAPVKDIKTL LLQVVSDKTG YPHEMLGMEM
DLEADLSIDS IKRVEIIGTL RSELGALTSG NADEDTVMEK LASIKTLSGL VSWLTELTGT
STAAPETNGT TGTPTPEVES KSALSLEELQ NIILDIVSEK TGYPKEMLGL DLDLEADLSI
DSIKRMEIIG DLKTKIGFGQ DMDQADDLME KLAAIKTLKG LASWISEMSG NTDADAEPVQ
NLLSRLRFDL TPTDVSAEQN TEIIKGKRFA ITQDNSPQTM AIKNTLEKYG AIAELVDTER
DLKDFDGLII LDLFSSTVKH SIIDHVDQIK KLDLDKAKWV YLISDIPAHI QELTDTRLLR
HYKGYPGLFK SLAREFEQTS CRLISLSTPQ EVDQITEIAL KEILTTDKPS EVVYKHDQRH
KIEIIPSPLS TSLEEAHIQL DQESVVLVLG GGQGITAELV KHMSGAYPCT YILVGRSADP
RDVIADLKEV EAMKTKEEIR SYLIKTGKFT SPSEIEKETV RIFKNNQILR TIRDMEQLGN
KVVYQSLDLC DEEGLSDLIK NIYGKYSRLD GVIHGAGLLE DKLFRQKTSS SFERVFDTKV
KPLRVLAEQL RADCQFVVLF SSIASVYGNK GQTDYAAANS VLDDYAKALN KKLKGKVISI
NWGPWKGAGM VSSTLETEYE RRGISLIPLD QGKEIFLNEI KYGTESQVLI MSGNNW
//
