ID A0A0J7KWL4_LASNI Unreviewed; 962 AA.
AC A0A0J7KWL4;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Netrin receptor UNC5 {ECO:0000256|RuleBase:RU367033};
GN ORFNames=RF55_5196 {ECO:0000313|EMBL:KMQ94639.1};
OS Lasius niger (Black garden ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Formicinae; Lasius; Lasius.
OX NCBI_TaxID=67767 {ECO:0000313|EMBL:KMQ94639.1, ECO:0000313|Proteomes:UP000036403};
RN [1] {ECO:0000313|EMBL:KMQ94639.1, ECO:0000313|Proteomes:UP000036403}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Whole {ECO:0000313|EMBL:KMQ94639.1};
RA Konorov E.A., Nikitin M.A., Kirill M.V., Chang P.;
RT "Lasius niger genome sequencing.";
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Receptor for netrin required for axon guidance. Mediates axon
CC repulsion of neuronal growth cones in the developing nervous system
CC upon ligand binding. {ECO:0000256|RuleBase:RU367033}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU367033};
CC Single-pass type I membrane protein {ECO:0000256|RuleBase:RU367033}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the unc-5 family.
CC {ECO:0000256|ARBA:ARBA00009844, ECO:0000256|RuleBase:RU367033}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KMQ94639.1}.
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DR EMBL; LBMM01002575; KMQ94639.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0J7KWL4; -.
DR STRING; 67767.A0A0J7KWL4; -.
DR PaxDb; 67767-A0A0J7KWL4; -.
DR OrthoDB; 2971005at2759; -.
DR Proteomes; UP000036403; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005042; F:netrin receptor activity; IEA:UniProtKB-UniRule.
DR CDD; cd08781; Death_UNC5-like; 1.
DR Gene3D; 2.60.220.30; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 2.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR037936; UNC5.
DR InterPro; IPR033772; UPA.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR12582:SF47; NETRIN RECEPTOR UNC-5; 1.
DR PANTHER; PTHR12582; NETRIN RECEPTOR UNC5; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF00090; TSP_1; 2.
DR Pfam; PF17217; UPA; 1.
DR Pfam; PF00791; ZU5; 1.
DR PRINTS; PR01705; TSP1REPEAT.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00209; TSP1; 2.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 2.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS50092; TSP1; 2.
DR PROSITE; PS51145; ZU5; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU367033};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319,
KW ECO:0000256|RuleBase:RU367033}; Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367033};
KW Reference proteome {ECO:0000313|Proteomes:UP000036403};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 238..353
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 532..645
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 892..958
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 82..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 495..531
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 82..96
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 106..121
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 504..521
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 962 AA; 105225 MW; EFC9DCB94AD5EFB2 CRC64;
MFPQGSSSTA PLPPSGCSSD IHSILTKADA LAVDERGRKT FAEESAASGI ASTNHHHRHY
TITTIAVTVV VVVVAAAADT ATIGSSSSSN TPDDKGMKKS VGTKEEDDAE EDDEESYPVE
DYDYGDYETA TITSDTDLIA GGSLPIFLAE PVDTFVVKGK PATLHCRAAH ALQVYFRCNG
DRAERSQQQD FVDPRTGTRV VEVELNVTRN EVEEYFGKER FKCECVAWSG PGQIRGQPAT
VEVAYLKKHF LSPPYSLSVE VGRNAELRCS PPLGVPTPKV YWLRNGSPLE TTAAGAASAS
SDADPNEASA SGFVQSADGH LLLGEAELRH QGNYSCVAEN LAARRVSEPA VLTTYVNGGW
SSWSGWSECS VRCGRGVQKR TRTCTNPVPI NGGQTCPGPA TQRVECNPSC PGRDVSIFLA
RKSDNRNLIE IFNFTPLHTA VDGRWSTWAS WSVCGPDCSR VRRRSCNDPP PSNGGRPCQG
KDVIVESCST DRCNGSTYQA NPESTNEDDD EQDDDERPDE NERSATDDGS GFIVKAIIDE
QGALLVVPEV GVSMSVPEGA IPRGRRHSLH LAVLGENSFR PNLPPGLTLL SAVVACGPAG
IDLVKPVILQ FEHCAELRTG NWELSLWSAE IDLETRSNNS TSSSMSSNGS TSVTAWRKVL
MLGGDPTNMP GQPFAQLDHA GVFLVTETPS VYAVAGENSV VAPGLAVKRL CVAVFLSRER
DHVRCRVLED TKASFKLVSE QERRLGSTHI DHGTLGFRAS GTSLRIDLED RESGFAERLE
VPYRRIWASS RISIRRSFRI EKIVGDLRLG FELRACQRGF EDQCLLLRID LDLVKRNNMS
GKRNANKTES SIVLRTKNSA RSTESVVPRP FRFSKTLRKQ LCQCLDPPSA RGNDWRMLAQ
RLQVDRYVDY FATKASPTEH ILDLWEARHR ETTALADLLN HLRLMGRVDA ANVLESRLGP
WI
//
