ID A0A0J7KZZ3_LASNI Unreviewed; 1138 AA.
AC A0A0J7KZZ3;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Regulator of g-protein signaling 12 {ECO:0000313|EMBL:KMQ95908.1};
GN ORFNames=RF55_3844 {ECO:0000313|EMBL:KMQ95908.1};
OS Lasius niger (Black garden ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Formicinae; Lasius; Lasius.
OX NCBI_TaxID=67767 {ECO:0000313|EMBL:KMQ95908.1, ECO:0000313|Proteomes:UP000036403};
RN [1] {ECO:0000313|EMBL:KMQ95908.1, ECO:0000313|Proteomes:UP000036403}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Whole {ECO:0000313|EMBL:KMQ95908.1};
RA Konorov E.A., Nikitin M.A., Kirill M.V., Chang P.;
RT "Lasius niger genome sequencing.";
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KMQ95908.1}.
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DR EMBL; LBMM01001674; KMQ95908.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0J7KZZ3; -.
DR STRING; 67767.A0A0J7KZZ3; -.
DR PaxDb; 67767-A0A0J7KZZ3; -.
DR OrthoDB; 22856at2759; -.
DR Proteomes; UP000036403; Unassembled WGS sequence.
DR GO; GO:0071944; C:cell periphery; IEA:UniProt.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0048699; P:generation of neurons; IEA:UniProt.
DR GO; GO:0051179; P:localization; IEA:UniProt.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 1.10.196.10; -; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR003109; GoLoco_motif.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR046995; RGS10/12/14-like.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR024066; RGS_subdom1/3.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45945; REGULATOR OF G-PROTEIN SIGNALING LOCO; 1.
DR PANTHER; PTHR45945:SF3; REGULATOR OF G-PROTEIN SIGNALING LOCO; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00640; PID; 1.
DR Pfam; PF00615; RGS; 1.
DR PRINTS; PR01301; RGSPROTEIN.
DR SMART; SM00390; GoLoco; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00462; PTB; 1.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50877; GOLOCO; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50132; RGS; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000036403};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 17..94
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 510..627
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT REGION 669..689
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1080..1112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 669..687
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1080..1096
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1138 AA; 126846 MW; CAB9756B6EF144A0 CRC64;
MHQNRRKKKR VNYGVRAVEV IRGAKGFGFT ISGQQPCILS CIVQGSPAEG AGLRAGDYLV
AVNGHNVSKV PHDDVVQLIG NSKGVLRLQI AENYYSDSDE EGLATVRSKP KYAHKPRVAN
ASALQLQCRA AKVVRDLQSG AMFHASLGGL VSDSKDQYNY SVLHYRWNMT SPLPPPPPPV
SHKRDSEKIV HRTVVGYLGT IDIPNQLHPS CMMQVLRKCI KRLKAEKRNP TTVLLTIHVA
NIKLTNSENR VIAEYPSYRI IFCNSFSEQD KQYFGILTKS MKNTDDIVSN SCHVFTIYYK
LIDHENISAR SSRELASEAA EHRLAVRAIS ETKWSKELKF IDFSKGMRHV AGSGGEGTTT
TCVTGTSAPV AAARGALAAS TSVGSLASVC TTALLDGIED AAESSTRAAS TAKLKRLMDT
TNKLSPKVYC GQVGTKSLVH SLEDINSSME YARPPFCHSY SGKSDKPRPW GSLQEIRNFG
SSVSDNYIYG STESCDKNND CKGVHTWANG FEKLLEDPKG LQTFAEFLKK EFSHENIYFW
AACERYKDTK DSGMRRRLAC QIYQRHLSNT AAEPVNVDSH ASGQITQELL DEAPADLFLQ
AQKQVFNLMK FDSYPRFLRS ELYRACLEAG SAIVDTEDCD LHLTNSPSVK LKKSHSDAED
RCRKSILPWN RKNRSKSKDR GESEYNKVPS RSETIYKSFT TIKRDTEGNN NEDSVSISSS
RSSLASWDLA LRQSFNKHMV DTKCFSSVLA GQEVEVVLTK VLKVELPSRR IISVIAHKGK
TLKEVLRPLL NKYGFNLDLI SIWNEGHCVP MDIMAINAPT RLIVVANEED FQRELHTAKY
LDEVPHVQPT LDEITNKVFE ELLVGKSRNK YQYSEGSCKS DDQRSEGSSI LSSKFFLRDS
TIHGKKKAKS KYCNTTEKGN TNDCVHEGAP VKSQPPLIAK WRNGVKLQLP GRFDGDDLYE
GLKRAQRSRL EDQRGTEINF ELPDFLKNKE NGKPSASNKM RRTRVVSANC EGTTKFYDSE
DKQSSCSGYD YPAHVTNGVL NERFSALVTE PLSKCLDSSF TLDGDRTLVD ADQTIIENCT
NSQSKSPCSE SYGTDMSRGK LSKPPPLPPK PKNLVVNVVK SGYIMSPKTL QRPNHVIE
//
